Brett Spear, Ph.D.

Huang, M.-C., K.K. Li and B.T. Spear. 2002. The Mouse Alpha-fetoprotein Promoter is Repressed in HepG2 Hepatoma Cells by Hepatocyte Nuclear Factor-3 (FOXA). DNA Cell Biol. In press

Calfee-Mason, K.G., B.T. Spear and Howard P. Glauert. 2002. Effects of Vitamin E on the NF-kB Pathway in Rats Treated with the Peroxisome Proliferator Ciprofibrate J. Nutrition, In press

Tharappel, J.C., E. Y. Lee, L. W. Robertson, B. T. Spear, and H. P. Glauert. 2002. Regulation of Cell Proliferation, Apoptosis, and Transcription Factor Activities During the Promotion of Liver Carcinogenesis by PCBs. Toxicol. Appl. Pharmacol., 179:172-184

Tharappel, J.C., M.L. Cunningham, B.T. Spear, and H.P. Glauert. 2001. Differential activation of hepatic NF-kB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil and dibutyl phthalate. Toxicol. Sci. 62:20-27

Peyton, D.K., T. Ramesh, and B.T. Spear. 2000. Position-dependent activity of alpha-fetoprotein enhancer element III in the adult liver is due to negative regulation. Proc. Natl. Acad. Sci., USA. 97:10890-10894

Peyton, D.K., M.C. Huang, M.A. Giglia, N.K. Hughes, and B.T. Spear. 2000. The alpha-fetoprotein promoter is the target of Afr1-mediated postnatal repression. Genomics. 63:173-80

Spear, B.T. 1999. Alpha-fetoprotein gene regulation: Lessons from transgenic mice. Seminars in Cancer Biology. 9(2):109-116

Perincheri, S. , R.W.C. Dingle, M.L. Peterson, and Brett T. Spear (2005) Hereditary persistence of α-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene. PNAS, 102, 396-401 [Abstract]