Microbiology, Immunology & Molecular Genetics

Office: (859) 257-5447 Fax: (859) 257-8994 Lab: (859) 257-5447 Email: btpan@uky.edu

Bin-Tao Pan, Ph.D.
Associate Professor

Doctoral Studies: McGill University, Canada.
Postdoctoral: Dana-Farber Cancer Institute, Harvard Medical School.

Research Statement:

My laboratory studies the mechanism by which oncogenic Ras induces tumors. Expression of oncogenic Ras in cells induces chromatin changes and cuases tumor development. Gross changes in chromatin can be induced within one cell cycle after expression of oncogenic Ras. We hypothesize that oncogenic Ras induces tumors through its effect on chromatin. We study the chromatin changes and the Ras signaling pathways leading to the changes.

Selected Recent Publications:

Chen, D.H., Chen, C.T., Zhang, Y., Liu, M.A., Campos-Gonzalez, R., and Pan, B.T. Characterization of p96: immunoreaction with an anti-Erk peptide antibody and activity in Xenopus oocytes and eggs. Biochem. J. 335:43-50, 1998.