Francesc Marti , Ph.D.

Assistant Professor

Selected publications

T lymphocytes play a major role in the generation of the host response against pathogens, control of autoimmune and inflammatory reactions and cancer surveillance. In physiological conditions, an effective T cell response occurs in a microenvironment that facilitates the coordinated action of multiple regulatory mechanisms, including the interplay with some specific T cell subsets. In this context, emerging data reveal the critical role of two small T cell subpopulations: regulatory T cells (Tregs) and gamma-delta T cells. A current major effort in our lab is to elucidate the cellular and molecular mechanisms involved in the activation of these two subsets and their contribution to the regulation of the immune response. To address these questions we are undertaking a similar strategy for both cell types: 1) to define the conditions that drive their maturation and function; 2) to analyze specific signaling events engaged upon their activation; 3) to uncover the cellular and molecular mechanisms underlying their impaired activity in pathological conditions. Our research involves a broad range of cellular, molecular, biochemical and imaging procedures performed largely in primary human cells but also in mouse models. The common long term goal is to develop rational strategies to manipulate deficient T cell function with the purpose to induce, direct or restore the normal immune response. We have established fruitful collaborative efforts inside and outside the University of Kentucky to support our findings and to help us to provide a strong rationale for the design of novel therapeutic approaches.