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Office: (859) 257-6573
Fax: (859) 257-8994
Lab: (859) 257-6574
Email: cskaet@uky.edu
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Charlotte Kaetzel, Ph.D.
Professor
Doctoral Studies: University of Maryland.
Postdoctoral: University of Maryland and Case Western Reserve University.
Research Statement:
Immunoglobulin A (IgA) antibodies are the first line of immune defense in mucous membranes, protecting the respiratory, gastrointestinal and genitourinary tracts from inhaled, ingested and sexually transmitted pathogens. Transport of IgA across mucosal epithelial cells into external secretions is mediated by the polymeric immunoglobulin receptor (PIGR). Our laboratory studies regulation of the expression and function of PIGR and other immune regulatory factors in intestinal epithelial cells during health and disease. Inflammatory bowel disease (IBD) results from a dysregulated immune response to the commensal microbiota in genetically susceptible individuals. Our recent studies have focused on the role of commensal gut bacteria in regulating epithelial gene expression, and how this balance becomes dysregulated in IBD. To this end we utilize a variety of genetic and transgenic mouse models, as well as human intestinal biopsies and cell-lines. Our long-term goal is to increase our understanding of immune mechanisms that regulate intestinal homeostasis and inflammation, and to develop novel approaches for the diagnosis and treatment of IBD.
Grants:
Crohn's & Colitis Foundation of America Senior Research Award
Kaetzel (PI) 02/01/2011 – 01/31/2014
Cross-talk between gut bacteria and intestinal epithelial cells in IBD
NIH/NIDCCR: 5P20RR020145-03
Ebersole, J.L. (PI) 9/1/2009 - 8/31/2014
Center for Biologic Basis of Oral/Systemic Diseases
Project: Periodontitis in Patients with Inflammatory Bowel Disease
Selected Recent Publications:
Johansen FE, Kaetzel CS. Regulation of the polymeric immunoglobulin receptor and IgA transport: New advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal Immunol. 2011; Advance online publication, September 28, 2011; doi:10.1038/mi.2011.37 PDF
Bruno ME, Frantz AL, Rogier EW, Johansen FE, Kaetzel CS. Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-kappaB pathways in intestinal epithelial cells. Mucosal Immunol. 2011 Jul;4(4):468-78. doi: 10.1038/mi.2011.8. Epub 2011 Mar 30. PubMed PMID: 21451502; PubMed Central PMCID: PMC3125104. PDF
Danaher RJ, Kaetzel CS, Greenberg RN, Wang C, Bruno ME, Miller CS. HIV protease inhibitors alter innate immune response signaling to double-stranded RNA in oral epithelial cells: implications for immune reconstitution inflammatory syndrome? AIDS. 2010 Oct 23;24(16):2587-90. PubMed PMID: 20841991; PubMed Central PMCID: PMC3166643. PDF
Bruno ME, Rogier EW, Frantz AL, Stefka AT, Thompson SN, Kaetzel CS. Regulation of the polymeric immunoglobulin receptor in intestinal epithelial cells by Enterobacteriaceae: implications for mucosal homeostasis. Immunol Invest. 2010;39(4-5):356-82. PubMed PMID: 20450283. PDF
Arsenescu R, Bruno ME, Rogier EW, Stefka AT, McMahan AE, Wright TB, Nasser MS, de Villiers WJ, Kaetzel CS. Signature biomarkers in Crohn's disease: toward a molecular classification. Mucosal Immunol. 2008 Sep;1(5):399-411. Epub 2008 Jul 2. PubMed PMID: 19079204. PDF
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