Leslie J. Crofford, M.D.
Chief, Division of Rheumatology
Doctoral Studies: University of Tennessee Center for Health Sciences, College of Medicine.
Postdoctoral: Barnes Hospital, Washington University School of Medicine.
Research Statement:
The role of lipid mediators in immune/inflammatory arthritis.
Grants:
Current
I.D. Number: NIH/NCRR – 1 KL2 RR033171, 1 TL1 RR033172, 1 UL1 RR033173
Role: Co-Investigator, Director PCIR, Executive Committee
Effort: 4.20 calendar months
Total Project Period: 06/01/11-02/29/16
Total Direct Costs: $1,956,108 (KL2), $760,000 (TL1), $11,800,413 (UL1)
I.D. Number: NIH/NIAMS – 2 R01 AR049010
Role: Principal Investigator
Title: Prostaglandin E Synthase in Rheumatoid Arthritis
Effort: 1.80 calendar months
Total Project Period: 11/01/04-01/30/14
Total Direct Costs: $1,125,000
I.D. Number: NIH/NIAID/DAIT - N01 AI05419 (Sullivan, PI Duke Univ)
Role: Site Principal Investigator, Overall Study Steering Committee
Title: Scleroderma: Cyclophosphamide or Transplant (SCOT)
Effort: 0.60 calendar months
Total Project Period: 09/01/05-08/31/16
Total Direct Costs: $100,000
I.D. Number: NIH/NHLBI - 1 R01 HL082835 (King, PI)
Role: Co-Investigator
Title: The role of Prostaglandin E2 in Angiotensin II-induced vascular disease
Effort: 0.60 calendar months
Total Project Period: 11/01/07-10/31/11
Total Direct Costs $250,000
I.D. Number: NIH/NCRR - 3 P20 RR020145 (Ebersole, PI)
Role: Co-Principal Investigator Project (Reny de Leuuw, DDS, PhD)
Title: Physiology of the Stress Response in Patients with Temporomandibular Disorder and Fibromyalgia. Center for the Biologic Basis of Oral/Systemic Disease (CBBOSD)
Effort: 0.60 calendar months
Project Period: 9/24/2010 – 9/23/2012
Total Direct Costs: $7,497,684
I.D. Number: American College of Rheumatology Research and Education Foundation Rheumatology Scientist Development Award
Role: Mentor (Elizabeth Salt, ARNP, PhD)
Title: Improved risk communication in patients with Rheumatoid Arthritis
Effort: 0 calendar months
Total Project Period: 7/01/10-6/30/13
Total Direct Costs: $225,000
I.D. Number: NIH/NIAMS - 1 R34 AR
Role: Co-Principal Investigator (Kathleen Sluka, PhD); Site PI
Title: Effectiveness of TENS on fibromyalgia pain
Effort: 0.60 calendar months
Total Project Period: 02/1/2011-01/31/2012
Total Direct Costs: $100,000
Pending
I.D. Number: 1 R01
Role: Co-Principal Investigator (Reid)
Title: Skeletal Muscle Function in Rheumatoid Arthritis
Effort: 0.60 calendar months
Total Project Period: 11/1/2011-10/31/2016
Total Direct Costs: $2,000,000
I.D. Number: 1 R01
Role: Co-Principal Investigator (Segerstrom)
Title: Pain and well-being in older women: The roles of activity and motivation
Effort: 0.60 calendar months
Total Project Period: 02/01/2012-01/31/2017
Total Direct Costs: $2,000,000
I.D. Number: 1 P50 DA033941-01
Role: Principal Investigator, Administrative Core Director, Project IV Co-inv
Title: Sex/Gender and Tobacco Abstinence or Relapse (STAR)
Effort: 3.0 calendar months
Total Project Period: 02/01/2012-01/31/2017
Total Direct Costs: $4,000,000
I.D. Number: 1 UM1
Role: Co-Principal Investigator (Sluka, Univ of Iowa); Site PI
Title: Fibromyalgia Activity Study with TENS (FAST)
Effort: 1.2 calendar months
Total Project Period: 02/01/2012-01/31/2017
Total Direct Costs: $2,500,000
Selected Recent Publications:
Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP.
Kunisch E, Jansen A, Kojima F, Löffler I, Kapoor M, Kawai S, Rubio I, Crofford LJ, Kinne RW.
J Immunol. 2009 Jul 15;183(2):1328-36. Epub 2009 Jun 19.
PMID: 19542367 [PubMed - in process] Related Articles
Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.
Kojima F, Kapoor M, Kawai S, Yang L, Aronoff DM, Crofford LJ.
Prostaglandins Other Lipid Mediat. 2009 Jun;89(1-2):26-33. Epub 2009 Mar 25.
PMID: 19464664 [PubMed - in process] Related Articles
The effects of pregabalin on sleep disturbance symptoms among individuals with fibromyalgia syndrome.
Russell IJ, Crofford LJ, Leon T, Cappelleri JC, Bushmakin AG, Whalen E, Barrett JA, Sadosky A.
Sleep Med. 2009 Jun;10(6):604-10. Epub 2009 May 1.
PMID: 19410509 [PubMed - in process] Related Articles
A symptom-based approach to pharmacologic management of fibromyalgia.
Boomershine CS, Crofford LJ.
Nat Rev Rheumatol. 2009 Apr;5(4):191-9. Review.
PMID: 19337283 [PubMed - indexed for MEDLINE] Related Articles
Recommendations for use of selective and nonselective nonsteroidal antiinflammatory drugs: an American College of Rheumatology white paper.
American College of Rheumatology Ad Hoc Group on Use of Selective and Nonselective Nonsteroidal Antiinflammatory Drugs.
Arthritis Rheum. 2008 Aug 15;59(8):1058-73. No abstract available. Erratum in: Arthritis Rheum. 2008 Nov 15;58(11):1686. Dosage error in article text.
PMID: 18668613 [PubMed - indexed for MEDLINE] Related Articles
Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome.
Dadabhoy D, Crofford LJ, Spaeth M, Russell IJ, Clauw DJ.
Arthritis Res Ther. 2008;10(4):211. Epub 2008 Aug 8. Review.
PMID: 18768089 [PubMed - indexed for MEDLINE] Related Articles Free article in PMC | at journal site
Determining long-term efficacy for treatment of chronic pain in fibromyalgia patients.
Crofford LJ.
Pain. 2008 Aug 31;138(2):473-4; author reply 474. Epub 2008 Aug 5. No abstract available.
PMID: 18684565 [PubMed - indexed for MEDLINE] Related Articles
Patient perspectives on the impact of fibromyalgia.
Arnold LM, Crofford LJ, Mease PJ, Burgess SM, Palmer SC, Abetz L, Martin SA.
Patient Educ Couns. 2008 Oct;73(1):114-20. Epub 2008 Jul 21.
PMID: 18640807 [PubMed - indexed for MEDLINE] Related Articles
Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises.
Mease PJ, Arnold LM, Crofford LJ, Williams DA, Russell IJ, Humphrey L, Abetz L, Martin SA.
Arthritis Rheum. 2008 Jul 15;59(7):952-60.
PMID: 18576290 [PubMed - indexed for MEDLINE] Related Articles Free article in PMC | at journal site
Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.
Kojima F, Kapoor M, Yang L, Fleishaker EL, Ward MR, Monrad SU, Kottangada PC, Pace CQ, Clark JA, Woodward JG, Crofford LJ.
J Immunol. 2008 Jun 15;180(12):8361-8.
PMID: 18523303 [PubMed - indexed for MEDLINE] Related Articles Free article in PMC | at journal site
Pain management in fibromyalgia.
Crofford LJ.
Curr Opin Rheumatol. 2008 May;20(3):246-50. Review.
PMID: 18388513 [PubMed - indexed for MEDLINE] Related Articles
Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin.
Crofford LJ, Mease PJ, Simpson SL, Young JP Jr, Martin SA, Haig GM, Sharma U.
Pain. 2008 Jun;136(3):419-31. Epub 2008 Apr 8.
PMID: 18400400 [PubMed - indexed for MEDLINE] Related Articles
Sleep stage dynamics in fibromyalgia patients and controls.
Burns JW, Crofford LJ, Chervin RD.
Sleep Med. 2008 Aug;9(6):689-96. Epub 2008 Mar 7.
PMID: 18314389 [PubMed - indexed for MEDLINE] Related Articles
The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia.
Arnold LM, Crofford LJ, Martin SA, Young JP, Sharma U.
Pain Med. 2007 Nov-Dec;8(8):633-8.
PMID: 18028041 [PubMed - indexed for MEDLINE] Related Articles
Fibromyalgia: combining pharmacological and nonpharmacological approaches to treating the person, not just the pain.
Turk DC, Vierck CJ, Scarbrough E, Crofford LJ, Rudin NJ.
J Pain. 2008 Feb;9(2):99-104. Epub 2007 Nov 1. Review. No abstract available.
PMID: 17936075 [PubMed - indexed for MEDLINE] Related Articles
Development of a provisional core set of response measures for clinical trials of systemic sclerosis.
Khanna D, Lovell DJ, Giannini E, Clements PJ, Merkel PA, Seibold JR, Matucci-Cerinic M, Denton CP, Mayes MD, Steen VD, Varga J, Furst DE; Scleroderma Clinical Trials Consortium co-authors.
Ann Rheum Dis. 2008 May;67(5):703-9. Epub 2007 Sep 24.
PMID: 17893248 [PubMed - indexed for MEDLINE] Related Articles
Why is the management of fibromyalgia syndrome so difficult for rheumatologists?
Scarbrough E, Crofford LJ.
Nat Clin Pract Rheumatol. 2007 Sep;3(9):480-1. No abstract available.
PMID: 17646867 [PubMed - indexed for MEDLINE] Related Articles
Violence, stress, and somatic syndromes.
Crofford LJ.
Trauma Violence Abuse. 2007 Jul;8(3):299-313. Review.
PMID: 17596347 [PubMed - indexed for MEDLINE] Related Articles
Fibromyalgia syndrome.
Mease P, Arnold LM, Bennett R, Boonen A, Buskila D, Carville S, Chappell A, Choy E, Clauw D, Dadabhoy D, Gendreau M, Goldenberg D, Littlejohn G, Martin S, Perera P, Russell IJ, Simon L, Spaeth M, Williams D, Crofford L.
J Rheumatol. 2007 Jun;34(6):1415-25.
PMID: 17552068 [PubMed - indexed for MEDLINE] Related Articles
High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study.
Nash RA, McSweeney PA, Crofford LJ, Abidi M, Chen CS, Godwin JD, Gooley TA, Holmberg L, Henstorf G, LeMaistre CF, Mayes MD, McDonagh KT, McLaughlin B, Molitor JA, Nelson JL, Shulman H, Storb R, Viganego F, Wener MH, Seibold JR, Sullivan KM, Furst DE.
Blood. 2007 Aug 15;110(4):1388-96. Epub 2007 Apr 23.
PMID: 17452515 [PubMed - indexed for MEDLINE] Related Articles Free article in PMC | at journal site
Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: a time course study.
Kapoor M, Kojima F, Yang L, Crofford LJ.
Prostaglandins Leukot Essent Fatty Acids. 2007 Feb;76(2):103-12. Epub 2007 Jan 18.
PMID: 17239574 [PubMed - indexed for MEDLINE] Related Articles Free article in PMC | at journal site
Proposed response criteria for neurocognitive impairment in systemic lupus erythematosus clinical trials.
Ad Hoc Committee on Lupus Response Criteria: Cognition Sub-committee, Mikdashi JA, Esdaile JM, Alarcón GS, Crofford L, Fessler BJ, Shanberg L, Brunner H, Gall V, Kalden JR, Lockshin MD, Liang MH, Roberts N Jr, Schneider M.
Lupus. 2007;16(6):418-25. Review.
PMID: 17664232 [PubMed - indexed for MEDLINE] Related Articles
Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway.
Kapoor M, Kojima F, Qian M, Yang L, Crofford LJ.
J Biol Chem. 2007 Feb 23;282(8):5356-66. Epub 2006 Dec 22.
PMID: 17186945 [PubMed - indexed for MEDLINE] Related Articles Free article in PMC | at journal site
Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis.
Kapoor M, Kojima F, Qian M, Yang L, Crofford LJ.
FASEB J. 2006 Nov;20(13):2387-9. Epub 2006 Oct 3.
PMID: 17023389 [PubMed - indexed for MEDLINE] Related Articles Free article in PMC | at journal site
Cardiovascular effects of selective COX-2 inhibition: is there a class effect? The International COX-2 Study Group.
Crofford LJ, Breyer MD, Strand CV, Rushitzka F, Brune K, Farkouh ME, Simon LS.
J Rheumatol. 2006 Jul;33(7):1403-8. Epub 2006 May 15.
PMID: 16724374 [PubMed - indexed for MEDLINE] Related Articles
Major enzymatic pathways in dermal wound healing: current understanding and future therapeutic targets.
Kapoor M, Kojima F, Appleton I, Kawai S, Crofford LJ.
Curr Opin Investig Drugs. 2006 May;7(5):418-22. Review.
PMID: 16729717 [PubMed - indexed for MEDLINE] Related Articles
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