Department of Microbiology, Immunology and Molecular Genetics
Schedule - 2006
Introduction - PU1 and stem cells
Lymphocyte Development Curr Opin Immunol Kincade 2005 Cytokines Transc factors lineage committment Oncogene 2002 Zhu Transcription Lineage specific Boessays 2004 Kluger
Notch Overview from Non Lymphoid systems
Louise Lines Paper 1 Zhou et al Notch EBNA Hsieh Hayward Science 1995 Notch Review Int J Hematology 2005 Radtke Notch signaling cell fate DEVELOPMENT 2004 Lai
Notch Immune system Immunity 2003 Maillard Siva-paper 1-notch T Vs B Siva-paper 2-notch vdj Siva-paper 3-Pax5
CD4 CD8 commitment Curr Opin Immunol 2005 BJ Fowlkes CD4 CD8 commitment Nature 2005 Robey CD4 CD8 commitment Nature immunol 2005 Kappes CD4 CD8 commitmentTh-POK nature 2005 Kappes Epigenetic silencing of CD4 in T cells
Chaplin-Hashi PP Compartment JI 2001 Chaplin-Nishikawa Organogen ImmRev 2003 Chaplin-Cupedo CellsLNDev JImm 2005 Chaplin-Adachi PP 3 steps IntImm 1997 Ehaplin-Cupedo LN Immunity 2004
Chemokine driven positive feedback loop Organogenesis of Lymphoid Tissues Overlapping Roles of CXCL13 IL7R and CCR7 Presumptive LN Organizers are Differentially Represented
Blood Feb 2006 Immunol Rev 2003 Paper MI707
Cutting Edge A Critical Role for Gene Silencing in Preventing - Excessive Type 1 Immunity DNA methylation and T cell commitment Epigenetic control in the immune response Epigenetic regulation of Th1 and Th2 cell development Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator
mz b cell review Notch2 Haploinsufficiency Results in Diminished B1 B Cells... Regulation of Marginal Zone B Cell Development ... Tucker - Identification of a B1 B cell-specified progenitor
miRNA primer Micro RNA Lineage Science 2004 Chen Micro RNA dicer KO JEM 2005 Cobb Amy - Nature microRNA oncogene
Notch tumorogenesis Nat Rev Cancer 2003 Radtke Notch tumorogenesis BLOOD 2005 Leong Notch1 Activating Mutations in human TALL Science 2004 Weng Notch 3 pre-TCR crosstalk-BLOOD 2006 Screpanti
