Office: (859) 323-2889
Fax: (859) 257-8994
Lab: (859) 323-2780
J. Scott Bryson, Ph.D.
Doctoral Studies: Miami University.
Postdoctoral: University of Kentucky.
My laboratory has been interested in studying the mechanisms responsible for the induction of murine cyclosporine A-induced syngeneic graft-versus-host disease (SGVHD). Ongoing work in this model has ranged from describing the regulation and pathogenesis associated with the induction and adoptive transfer of this disease, to analysis of T cell clones isolated from diseased animals. It has been shown clinically that a beneficial consequence of GVHD following bone marrow transplantation (BMT) is the generation of anti-tumor or graft-versus-leukemia (GVL) responses. With this in mind, we are beginning to examine the GVL immune potential of SGVHD against transplantable murine tumors. A second area of interest is to study the effects of aging on the development of GVHD following BMT. Clinically, older patients have increased morbidity and mortality due to GVHD. Using a murine GVHD system, preliminary data has suggested that aged recipients of young adult donor cells have an increased incidence of GVHD when compared with young recipients animals. The mechanisms for this finding are unknown at the present time and will require further characterization.
Selected Recent Publications:
Perez J., Brandon J.A., Cohen D.A., Jennings C.D., Kaplan A.M., Bryson J.S. Accumulation of CD4+ T cells in the colon of CsA-treated mice following myeloablative conditioning and bone marrow transplantation. Am J Physiol. Gastrointest Liver Physiol. [Epub, 2011, Feb. 3]. PDF
Brandon, J.A., C.D. Jennings, A.M. Kaplan and J.S. Bryson. Murine syngeneic graft-versus-host disease is responsive to broad-spectrum antibiotic therapy. J. Immunol. 2011. 186:3726-34. [Epub 2011 Feb 4] PDF
Brandon, J.A., C.D. Jennings, A.M. Kaplan and J.S. Bryson. Development of a TH17 immune response during the induction of murine syngeneic graft-versus- host disease. Cytokine. 52:265-273, 2010. Epub 2010 Sep 15.
Brandon, J.A., J. Perez, C.D. Jennings, A.M. Kaplan and Bryson, J.S. Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease. Am. J. Physiol. Gastrointest. Liver Physiol.299:G602-G613, 2010. Epub 2010 Jul 15. PDF
Bryson, JS, Jennings CD, Brandon, JA, Perez, J, Caywood, BE, and Kaplan, AM. Adoptive transfer of murine syngeneic graft-versus-host disease by CD4+ T cells.. J. Leukocyte Biol. 82:1393-1400, 2007. PDF
Brandon J., Jennings, C.D., Perez, J., Caywood, B., Alapat, D., Kaplan, A.M., and Bryson, J.S. Induction of murine syngeneic graft-versus-host-disease by cells of recipient origin. Transplantation. 83:1620-1627, 2007. PDF
Hongo, D., Bryson, J.S., Kaplan, A.M., Cohen, D.A. Endogenous nitric oxide protects against T cell-dependent lethality during graft-vs-host disease and idiopathic pneumonia syndrome. J. Immunology. 173:1744-1756, 2004. PDF
Bryson, J.S., Zhang, L., Goes, S.W., Jennings, C.D., Caywood, B.E., Carlson, S.L. and Kaplan, A.M. CD4+ T cells mediate murine syngeneic graft-versus-host disease-associated colitis. J. Immunology. 172:679-687, 2004. PDF
Flanagan, D.M., C.D. Jennings, S.W. Goes, B.E. Caywood, R. Gross, A.M. Kaplan and J.S. Bryson. Nitric oxide participates in the intestinal pathology associated with murine syngeneic graft-versus-host disease. J. Leukoc. Biol. 2002; 72:762
Flanagan, D.M., C.D. Jennings, B.E. Caywood, R. Gross, S. Goes, A.M. Kaplan and J.S. Bryson. Induction of syngeneic graft-versus-host disease in LPS hyporesponsive C3H/HeJ mice. J. Leukoc. Biol. 70: 873, 2001