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Office: (859) 323-2889
Fax: (859) 257-8994
Lab: (859) 323-2780
Email: jsbrys@uky.edu
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J. Scott Bryson, Ph.D.
Associate Professor
Doctoral Studies: Miami University.
Postdoctoral: University of Kentucky.
Research Statement:
My laboratory has been interested in studying the mechanisms responsible for the induction of murine cyclosporine A-induced syngeneic graft-versus-host disease (SGVHD). Ongoing work in this model has ranged from describing the regulation and pathogenesis associated with the induction and adoptive transfer of this disease, to analysis of T cell clones isolated from diseased animals. It has been shown clinically that a beneficial consequence of GVHD following bone marrow transplantation (BMT) is the generation of anti-tumor or graft-versus-leukemia (GVL) responses. With this in mind, we are beginning to examine the GVL immune potential of SGVHD against transplantable murine tumors. A second area of interest is to study the effects of aging on the development of GVHD following BMT. Clinically, older patients have increased morbidity and mortality due to GVHD. Using a murine GVHD system, preliminary data has suggested that aged recipients of young adult donor cells have an increased incidence of GVHD when compared with young recipients animals. The mechanisms for this finding are unknown at the present time and will require further characterization.
Selected Recent Publications:
Brandon, J.A., C.D. Jennings, J. Perez, B.E. Caywood, D. Alapat, A.M. Kaplan and J.S. Bryson. Induction of murine syngeneic graft-versus-host disease by cells of recipient origin. Transplantation. 2007; 83:1620.
Bryson, J.S., C.D. Jennings, J.A. Brandon, B.E. Caywood and A.M. Kaplan. Adoptive transfer of murine syngeneic graft-versus-host disease by CD4+ T cells. J. Leukoc. Biol. 2007; 82:1393.
Bryson, J.S., L. Zhang, S.W. Goes, C.D. Jennings, S. Carlson, B.E. Caywood and A.M. Kaplan. CD4+ T cells mediate murine syngeneic graft-versus-host disease-induced colitis. J. Immunol. 2004; 172:679
Flanagan, D.M., C.D. Jennings, S.W. Goes, B.E. Caywood, R. Gross, A.M. Kaplan and J.S. Bryson. Nitric oxide participates in the intestinal pathology associated with murine syngeneic graft-versus-host disease. J. Leukoc. Biol. 2002; 72:762
Flanagan, D.M., C.D. Jennings, B.E. Caywood, R. Gross, S. Goes, A.M. Kaplan and J.S. Bryson. Induction of syngeneic graft-versus-host disease in LPS hyporesponsive C3H/HeJ mice. J. Leukoc. Biol. 70: 873, 2001
Bryson, J.S., D.L. Lowery, C.D. Jennings, D.L. Pflugh, B.E. Caywood and A.M. Kaplan. Rejection of an MHC class II negative tumor following induction of murine syngeneic graft-versus-host disease. Bone Marrow Transplantation. Bone Marrow Transplantation, 23:363-372, 1999
Lowery, D.M., C.D. Jennings, B.E. Caywood and J. S. Bryson. TH1-like cytokine response correlates with the development of murine syngeneic graft-versus-host disease. J.Immunol. 163:1170-1177, 1999
Bryson, J.S., C.D. Jennings, B.E. Caywood, A.R. Dix, D.M. Lowery and A.M. Kaplan. Enhanced graft-versus-host disease in older recipients following allogeneic bone marrow transplantation. Bone Marrow Transplantation. 19:721-728, 1997
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