Office phone: (859)323-2889
Fax: (859)257-8994
Lab phone: (859)323-2780
Department of Microbiology, Immunology and Molecular Genetics
J. Scott Bryson, Ph.D. |
Associate Professor |
Doctoral studies: Miami University. Postdoctoral: University of Kentucky. |
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Office phone: (859)323-2889 |
Selected publications |
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| Research statement: My laboratory has been interested in studying the mechanisms responsible for the induction of murine cyclosporine A-induced syngeneic graft-versus-host disease (SGVHD). Ongoing work in this model has ranged from describing the regulation and pathogenesis associated with the induction and adoptive transfer of this disease, to analysis of T cell clones isolated from diseased animals. It has been shown clinically that a beneficial consequence of GVHD following bone marrow transplantation (BMT) is the generation of anti-tumor or graft-versus-leukemia (GVL) responses. With this in mind, we are beginning to examine the GVL immune potential of SGVHD against transplantable murine tumors. A second area of interest is to study the effects of aging on the development of GVHD following BMT. Clinically, older patients have increased morbidity and mortality due to GVHD. Using a murine GVHD system, preliminary data has suggested that aged recipients of young adult donor cells have an increased incidence of GVHD when compared with young recipients animals. The mechanisms for this finding are unknown at the present time and will require further characterization. | |
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