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Office: (859) 323-4705
Fax: (859) 257-9608
Lab: (859) 257-5101
Email: bondada@uky.edu
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Subbarao Bondada, Ph.D.
Professor
Doctoral Studies: Tata Institute of Fundamental Research, Bombay.
Postdoctoral: National Institute of Health, Bethesda, MD and Institute for Cancer Research, Philadelphia, PA.
Research Statement:
Proliferation and differentiation of B-lymphocytes is dependent on receiving a variety of signals from antigens and from interaction with other immune cells. The signals are communicated by cell surface molecules, which induce specific biochemical changes in side B-cells and initiate a program of cell growth and antibody synthesis. We are studying the regulation of such signal transduction mechanisms and their physiological role in the modulation of immune responses, using transgenic mice in which genes for cell surface molecules and the components of the signal transduction pathway are either deleted or overexpressed. One project in the laboratory focuses on a subset of B-lymphocytes that is prone to produce autoantibodies and is elevated in autoimmune states. These concepts are also applied in a system that evaluates the immune responses to bacterial polysaccharides with a goal to increase the efficacy of vaccines against pneumococcal bacteria, which are important pathogens for children and elderly. A third program in the laboratory studies the role of a transcription factor Egr-1 in the growth regulation of normal B cells and B lymphoma cells.
Selected Recent Publications:
Fallah, M. P., R. L. Chelvarajan, B.A. Garvy, S. Bondada Role of Phosphoinositide 3-Kinase - AKT signaling Pathway in the age-related cytokine dysregulation in Splenic Macrophages Mechanisms of Ageing and Development (In press)
Zhao, Y., R. Burikhanov, J. Brandon, S. Qiu, B. J. Shelton, B. Spear, S. Bondada, S. Bryson and V. M. Rangnekar. Systemic Par-4 inhibits metastatic tumor growth (Cancer Biol and Therapy) (In Press).
Sultana, R. , F. Di Domenico, M Tseng, J. Cai , T. Noel , R. L. Chelvarajan, W. D. Pierce, C. Cini , S. Bondada , D. K. St Clair, and D. A. Butterfield. Doxorubicin-Induced Thymus Senescence. J Proteome Res. 2010 Dec 3;9(12):6232-6241. Epub 2010 Nov 9.PMID: 20945937.
Brandon, J., J. Jennings CD, Cohen DA, Sindhava VJ, Bondada S, Kaplan AM, Bryson JS. Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G602-13. Epub 2010 Jul 15.PMID: 20634434
Sindhava, V., M. Woodman, B. Stevenson and S. Bondada Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection. PLOS One 2010 Jul 6;5(7):e11445.PMID: 20625435
Ke, J., Chelvarajan, L., Sindhava, V., Lekakis, L., Jennings, D.J. and S. Bondada (2009) Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth. Molec. Cancer Dec 31;8:132-147. PMID: 20043832.
Dasu, T., V. Sindhava, S. G. Clarke and S. Bondada. CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes. Molecular Immunology 46: 2655-2665 (2009).
Wu,H.-S. and S. Bondada CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function. J. Clin. Immunol. 29:12-21 (2009) DOI: 10.1007/s10875-008-9264-6
Gururajan, M., A. Simmons, T. Dasu, B. T. Spear, C. Calulot, D. Robertson, D. Wiest, J. Monroe and S. Bondada. Early growth response gene-1 is required for B cell development, proliferation and immune response. J. Immunol 181(7):4590-602 (2008)
Bondada, S. and M. Gururajan. Importance of B cell receptor signaling for B lymphoma growth.
PLOS Biol. (2008) Comment on The B Cell Antigen Receptor and Overexpression of MYC Can Cooperate in the Genesis of B Cell Lymphomas Refaeli Y, Young RM, Turner BC, Duda J, Field KA, et al. PLoS Biology Vol. 6, No. 6, e152 doi:10.1371/journal.pbio.0060152
Dasu, T., J. E. Qualls, C. Raman, D. A. Cohen and S. Bondada. CD5 plays an inhibitory role in the suppressive function of T-regulatory cells Immunol. Lett. 2008;119(1-2):103-13 .
Yanming Zhao, R. Burikhanov, S. Qiu, S. M. Lele, S. Bondada, B. Spear, and V. M. Rangnekar. Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res 67:9276-9285 (2007).
Chelvarajan, R. L., D. Popa, Y. Liu, T.V. Getchell, A.J. Stromberg and S. Bondada. Molecular mechanisms underlying anti-inflammatory phenotype of neonatal macrophages. J. Leuk. Bol. 82:403-16. (2007)
Gururajan, M., T. Dasu, S. Shahidain, C. D. Jennings, D. A. Robertson, V. M. Rangnekar and S. Bondada. Curcumin inhibits B lymphoma growth by suppressing Syk, a novel target. J. Immunol. 178: 111-121(2007).
Ke, J., M. Gururajan, A. Kumar, A. Simmons, L. Turcios, Ralph L. Chelvarajan, D. M. Cohen, D. Wiest, J. Monroe and S. Bondada. The role of MAP Kinases in BCR induced down‑regulation of Egr-1 in immature B lymphoma cells. J. Biol. Chem. 281(52):39806-18 (2006).
Landers, C.D. and Subbarao Bondada What insights into human cord blood lymphocyte function can be gleaned from studying newborn mice Questions and Controversies in Neonatology Series, Hematology, Immunology, and Infectious Diseases Volume; Editors: Robin Ohls, and Mervin C. Yoder, (2006).
Gururajan, M., C. D. Jennings, and S. Bondada. Cutting Edge: Constitutive B cell receptor signaling is critical for basal growth of B lymphoma. J. Immunol. 176: 5715-5719 (2006).
S. Bondada and H-S. Wu Molecule Page, A000582, CD72, AfCS-Nature Molecule Pages (2006) (peer reviewed like any journal manuscript).
Chelvarajan, R. L., Y. Liu, D. Popa, M.L. Getchell, T.V. Getchell, A.J. Stromberg and S. Bondada. Molecular basis of age associated cytokine dysregulation in macrophages. J. Leuk. Bol. 79: 1314-1327 (2006).
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