Office of Medical Education

Go to Meeting Abstracts & In Preparation Articles

2011

Ailing Ji, Jason M. Meyer, Lei Cai, Akinwunmi Akinmusire, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen. Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis, in press.

Kevin N. Hascup, Erin R. Hascup,  Michelle L. Stephens, Paul E. A. Glaser, Takashi, Yoshitake, Aleksander A. Mathé, Greg A. Gerhardt, Jan Kehr 'Resting Glutamate Levels and Rapid Glutamate Transients in the Prefrontal Cortex of the Flinders Sensitive Line Rat—A Genetic Rodent Model of Depression'. Neuropsychopharmacology, accepted March 2011.

Scott R. Silva
Role of VEGFR-2 in carcinoid metastasis
Int. J. Cancer: 128, 1045–1056 (2011)

Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A. Structural basis of substrate discrimination and integrin binding by autotaxin.  Nat Struct Mol Biol. 2011;18:198-204. Featured in News and Views http://www.nature.com/nsmb/journal/vaop/ncurrent/abs/nsmb.1980.html

Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.  Nature. 2011 Feb 6. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09830.html

2010

Becker, J., Pavlakovic, H., Ludewig, F., Wilting, F., Weich, H.A., Albuquerque, R.J.C., Ambati, J., and Wilting, J., 2010, “Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2,” Clin. Cancer Res., 16:1431-41, PMID: 20179233.

Gregg, C., Zhang, J., Butler, J.E., Haig, D., and Dulac, C., 2010, “Sex-Specific Parent-of-Origin Allelic Expression in the Mouse Brain,” Science, [Epub ahead of print], PMID: 20616234.

Hatfield, M., Meyer, T., Meyer, J., Robles-Carrillo, L., Francis, J.L., and Amirkhosravi, A., 2010, “Contribution of Surface Localization to Platelet Activation by CD154 Antibodies and Introduction of a Novel Approach for Studying Immune Complex Activity,” Thromb. Res., [Epub ahead of print], PMID: 20083297.

Silva, S.R., Bowen, K.A., Rychahou, P.G., Jackson, L.N., Weiss, H.L., Lee, E.Y., Townsend, C.M. Jr., and Evers, B.M., 2010, “VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis,” Int. J. Cancer, [Epub ahead of print], PMID: 20473929.

Stephens, M.L., Pomerleau, F., Huettl, P., Gerhardt, G.A., and Zhang, Z., 2010, “Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype,” J. Neurosci. Methods, 185:264-72, PMCID: PMC2815042.

Wurth, M.A., Schowalter, R.M., Smith, E.C., Moncman, C.L., Dutch, R.E., and McCann, R.O., 2010, “The actin cytoskeleton inhibits pore expansion during PIV5 fusion protein-promoted cell-cell fusion,” Virology, 404:117-26, PMCID: PMC2885465.

2009

Albuquerque, R.J., Hayashi, T., Cho, W.G., Kleinman, M.E., Dridi, S., Takeda, A., Baffi, J.Z., Yamada, K., Kaneko, H., Green, M.G., Chappell, J., Wilting, J., Weich, H.A., Yamagami, S., Amano, S., Mizuki, N., Alexander, J.S., Peterson, M.L., Brekken, R.A., Hirashima, M., Capoor, S., Usui, T., Ambati, B.K., Ambati, J.. 2009, “Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth,” Nat. Med., 15:1023-30,(Epub 2009), PMID: 19668192.
   

Takeda, A., Baffi, J.Z., Kleinman, M.E., Cho, W.G., Nozaki, M,, Yamada, K., Kaneko, H., Albuquerque, R.J.C., Dridi, S., Saito, K., Raisler, B.J., Budd, S.J., Geisen, P., Munitz, A., Ambati, B.K., Green, M.G., Ishibashi, T., Wright, J.D., Humbles, A.A., Gerard, C.J., Ogura, Y., Pan, Y., Smith, J.R., Grisanti, S., Hartnett, M.E., Rothenberg, M.E., and Ambati, J., 2009, “CCR3 is a target for age-related macular degeneration diagnosis and therapy,” Nature, 460:225-30, PMCID: PMC2712122.

Cho, W.G., Albuquerque, R.J.C., Kleinman, M.E., Tarallo, V., Greco, A., Nozaki, M., Rich, M.G., Baffi, J.Z., Ambati, B.K., De Falco, M., Alexander, J.S., Brunetti, A., De Falco, S., and Ambati, J., 2009, “Small interfering RNA induced TLR3 activation inhibits blood and lymphatic vessel invasion,” Proc. Natl. Acad, Sci, U.S.A., 106:7137-42, PMCID: PMC2678451.

Butler, J.E., Moore, M.B., Presnell, S.R., Chan, H.W., Chalupny, N.J., and Lutz, C.T., 2009, “Proteasome regulation of ULBP1 transcription,” J. Immunol., 182:6600-9, PMCID: PMC2748925.

Smith, E.C., Popa, A., Chang, A., Masante, C., and Dutch, R.E., 2009, “Viral entry mechanisms: the increasing diversity of paramyxovirus entry,” FEBS J., 276:7217-27, PMCID2795005.

Schowalter, R.M., Chang, A., Robach, J.G., Buchholz, U.J., and Dutch, R.E., 2009, “Low-pH Triggering of Human Metapneumovirus Fusion: Essential Residues and Importance in Entry,” J. Virol., 83:1511-22, PMCID2620907.

Pamuklar, Z., Federico, L., Liu, S., Umezu-Goto, M., Dong, A., Panchatcharam, M., Fulkerson, Z., Berdyshev, E., Natarajan, V., Fang, X., van Meeteren, L.A., Moolenaar, W.H., Mills, G.B., Morris, A.J., and Smyth, S.S., 2009, “Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis,” Biol. Chem., 284:7385-94, PMCID: PMC2652269.  

Morris, A.J., Panchatcharam, M., Cheng, H.Y., Federico, L., Fulkerson, Z., Selim, S., Miriyala, S., Escalante-Alcalde, D., and Smyth, S.S., 2009, “Regulation of blood and vascular cell function by bioactive lysophospholipids,” J. Thromb. Haemost., 7 Suppl 1:38-43, PMCID: PMC2801156.

Grear, K.E., Ling, I.F., Simpson, J.F., Furman, J.L., Simmons, C.R., Peterson, S.L., Schmitt, F.A., Markesbery, W.R., Liu, Q., Crook, J.E., Younkin, S.G., Bu, G., and Estus, S, 2009, “Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimer’s disease brain,” Mol. Neurodegener., 4:46, PMCID: PMC2776013.

Nguyen, X.V., Liu, M., Kim, H.C., and Bing, G., 2009, “Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP,” Exp. Neurol., 219:228-238, PMID: 19500577.

Morris, A.J., Selim, S., Salous, A., and Smyth, S.S., 2009, “Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation,” Trends Cardiovasc. Med., 19:135-40, (Review), PMCID: PMC2761247.

Salous, A.K., Ren, H., Lamb, K.A., Hu, X.Q., Lipsky, R.H., and Peoples, R.W., 2009, “Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit,” Br. J. Pharmacol., 158:1395-404, PMCID: PMC2782349.

Salous, A., Al-Alem, L., and Omar, H.A., 2009, “Trends in mental health of an adolescent medicine clinic patient population,” Int. J. Adolesc. Med. Health, 21:9-14, PMID: 19526691.

Salous, A.K., Jones, V., Castro, M.M., Al-Alem, L., and Omar, H.A., 2009, “Weight gain associated with hormonal contraception use in adolescents is not different from control,” Int. J. Disabil. Hum. Dev., 8:181-5.

Salous, A. and Omar, H.A., 2009, “Substance abuse among adolescents: a cross-cultural review,” Int. J. Disabil. Hum. Dev., 8:155-8, (Review).

Gulhati, P., Cai, Q., Li, J., Liu, J., Rychahou, P.G., Qiu, S., Lee, E.Y., Silva, S.R,, Bowen, K.A.,
Gao, T., and Evers, B.M., 2009, “Targeted inhibition of mammalian target of rapamycin signaling
inhibits tumorigenesis of colorectal cancer,” Clin. Cancer Res., 15:7207-16, PMID: 19934294, PMCID: PMC2898570.

Bowen, K.A., Silva, S.R., Johnson, J.N., Doan, H.Q., Jackson, L.N., Gulhati, P., Qiu, S., Riall, T.S., and Evers, B.M., 2009, “An Analysis of Trends and Growth Factor Receptor Expression of GI Carcinoid Tumors,” J. Gastrointest. Surg., 13:1773-80, PMID: 19582519, PMCID: PMC2902268.

Jackson, L.N., Chen, L.A., Larson, S.D., Silva, S.R., Rychahou, P.G., Boor, P.J., Li, J., Defreitas, G., Stafford, W.L., Townsend, C.M. Jr., and Evers, B.M., 2009, “Development and characterization of a novel in vivo model of carcinoid syndrome,” Clin. Cancer Res., 15:2747-55, PMID: 19336516, PMCID: PMC2708940.

Chen, L.A., Li, J., Silva, S.R., Jackson, L.N., Zhou, Y., Watanabe, H., Ives, K.L., Hellmich, M.R., and Evers, B.M., 2009, “PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion,” J. Biol. Chem., 284:2459-71, PMID: 19028687, PMCID: PMC2629096.

Stephens, M.L., Quintero, J.E., Pomerleau, F., Huettl, P., Gerhardt, G.A., 2009, “Age-related changes in glutamate release in the CA3 and dentate gyrus of the rat hippocampus,” Neurobiol. Aging (Epub), PMID: 19535175.

2008

Ponticelli, S., Marasco, D., Tarallo, V., Albuquerque, R.J.C., Mitola, S., Takeda, A., Stassen, J.M., Presta, M., Ambati, J., Ruvo, M., and De Falco, S., 2008, “Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1,”.J.B.C., 283:34250-59, PMCID: PMC2590698.

Kleinman, M.E., Yamada, K., Takeda, A., Chandrasekaran, V., Nozaki, M., Baffi, J., Albuquerque, R.J.C., Yamasaki, S., Itaya, M., Pan, Y., Appukuttan, B., Gibbs, D., Yang, Z., Kariko, K., Ambati, B.K., Wilgus, T.A., DiPietro, L.A., Sakurai, E., Zhang, K., Smith, J.R., Taylor, E.W., and Ambati, J., 2008, “Sequence- and target-independent angiogenesis suppression by siRNA via TLR3,” Nature, 452:591-97, PMCID: PMC264293.

Butler, J.E. and Spear, B.T., 2008, “Normal intestinal epithelial cell differentiation in the absence of p21 and p27: new insights from old knock-out mice,” Cancer Biol. Ther., 7:880-1, PMID: 18509258.

Choi, S., Vastag, L., Larrabee, Y.C., Personick, M.L., Schaberg, K.B., Fowler, B.J., Sandwick, R.K., and Rawji, G., 2008, “Importance of platinum(II)-assisted platinum(IV) substitution for the oxidation of guanosine derivatives by platinum(IV) complexes,” Inorg. Chem., 47:1352-60, (Erratum in: Inorg. Chem., 2008, 47:3920), PMID: 18220340.

Fulkerson, Z., Morris, A.J., and Smyth, S.S., 2008, “Interactions of lysophospholipids with platelets,” International Review of Thrombosis, 3:26-33.

Olsen, M.A., Lefta, M., Dietz, J.R., Brandt, K.E., Aft, R., Matthews, R., Mayfield, J., and Fraser, V.J., 2008, “Risk factors for surgical site infection after major breast operation,” J. Am, Coll. Surg., 207:326-35, PMID: 18722936.

Bernard, A., Kasten, M., Meier, C., Manning, E., Freeman, S., Adams, W., Chang, P., Boulanger, B., and Kearney, P., 2008, “Red blood cell arginase suppresses Jurkat (T cell) proliferation by depleting arginine,” Surgery, 143:286-91, PMID: 18242346.

Liu, M., Hunter, R., Nguyen, X.V., Kim, H.C., and Bing, G., 2008, “Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment,” J. Neurosci. Res., 86:2792-2801, PMID: 18500758.

Suzuki, S., Gerhold, L.M., Böttner, M., Rau, S.W., Dela Cruz, C., Yang, E., Zhu, H., Yu, J., Cashion, A.B., Kindy, M.S., Merchenthaler, I., Gage, F.H., and Wise, P.M., 2007, “Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta,” J. Comp. Neurol., 500:1064-75, PMID: 17183542.

Stephens, M.L., Spencer, D.D.,  Cavus, I. , Hsiao, M., Song, D., Courellis, S.H., Deadwyler, S. A., Hampson, R.E., Putz, D., Quintero, J.E.,  Bensalem-Owen, M.K., Hascup, K.N., Rutherford, E.C., Day, B.K.,  Nickell, J.R., Pomerleau, F., Huettl, P., Burmeister, J.J., Talauliker, P.M., Marmarelis, V.Z., Granacki, J.J.,  Berger, T.,  and Gerhardt, G.A., 2008, “Microelectrode-based Epilepsy Therapy:  A Hybrid Neural Prosthesis Incorporating Seizure Prediction and Intervention with Biomemetic Maintenance of Normal Hippocampal Function ,” (540-63) Computational Neuroscience in Epilepsy, Academic Press, (Book Chapter).

Jackson, L.N., Larson, S.D., Silva, S.R., Rychahou, P.G., Chen, L.A., Qiu, S., Rajaraman, S., and Evers, B.M., 2008, “PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy,” Am. J. Physiol. Gastrointest. Liver Physiol., 294:G1401-10, PMID: 18388186, PMCID: PMC2427188.

Zaytseva, Y.Y., Wang, X., Southard, R.C., Wallis, N.K., and Kilgore, M.W., 2008, “Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells,” Mol. Cancer, 7:90, PMCID: PMC2614423.

Jin, Y., Ziemba, K.S., and Smith, G.M., 2008, “Axon growth across a lesion site along a preformed guidance pathway in the brain,” Exp. Neurol., 210:521-30, PMID: 18261727.

Ziemba, K.S., Chaudhry, N., Rabchevsky, A.G., Jin, Y., and Smith, G.M., 2008, “Targeting axon growth from neuronal transplants along preformed guidance pathways in the adult CNS,” J. Neurosci., 28:340-8, PMID: 18184776.

2007

Quintero, J.E., Day, B.K., Zhang, Z., Grondin, R., Stephens, M.L., Huettl, P., Pomerleau, F., Gash, D.M., and Gerhardt, G.A., 2007, “Amperometric measures of age-related changes in glutamate regulation in the cortex of rhesus monkeys,” Exp. Neurol., 208:238-46, PMID: 17927982.

Zhu, H., Tucker, H.M., Grear, K.E., Simpson, J.F., Manning, A.K., Cupples, L.A., and Estus, S., 2007, “A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol,” Hum. Mol. Genet., 16:1765-72, PMCID: PMC2361133.

Arimoto, T., Choi, D.Y., Lu, X., Liu, M., Nguyen, X.V., Zheng, N., Stewart, C.A., Kim, H.C., and Bing, G., 2007, “Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra,” Neurobiol. Aging, 28:894-906, PMID: 16769155.

Bruce-Keller, A.J., Dimayuga, F.O., Reed, J.L., Wang, C., Angers, R., Wilson, M.E., Dimayuga, V.M., and Scheff, S.W., 2007, “Gender and estrogen manipulation do not affect traumatic brain injury in mice,” J. Neurotrauma., 24:203-15, PMID: 17263684.

Ren, H., Salous, A.K., Paul, J.M., Lipsky, R.H., and Peoples, R.W., 2007, “Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action,” Br. J. Pharmacol., 151:749-57, PMCID: PMC2014122.

Lobner, D., Piana, P.M., Salous, A.K., and Peoples, R.W., 2007, “Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms,” Neurobiol. Dis., 25:360-6, PubMed PMID: 17098435.

Cai, J., Ziemba, K.S., Smith, G.M., and Jin, Y., 2007, “Evaluation of cellular organization and axonal regeneration through linear PLA foam implants in acute and chronic spinal cord injury,” J. Biomed. Mater. Res. A., 83:512-20, PMID: 17503492.

2006

Ambati, B.K., Nozaki, M., Singh, N., Jani, P.D., Takeda, A., Richter, E., Albuquerque, R.J.C., Suthar, T., Sakurai, E., Caldwell, R., Ogura, Y., Mahasreshti, P., Orecchia, A., Samuelson, D.A., Agnew, D.W., Leger, J.S., Ikeda, S., Leiper, L.J.,  Collinson, J.M., Bogdanovich, S., Khurana, T.S., Shibuya, M., Baldwin, M.E., Ferrara, N., Gerber, H.P., De Falco, S., Witta, J., Baffi, J.Z., Raisler, B.J., and Ambati, J., 2006, “Corneal avascularity is due to soluble VEGF receptor-1,” Nature, 443:993-7, (Edit. Review), PMCID: PMC2656128.

de Leeuw, R., Davis, C.E., Albuquerque, R., Carlson, C.R., and Andersen, A.H., 2006, “Brain activity during stimulation of the trigeminal nerve with noxious heat,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 102:750-7, PMID: 17138177.

Albuquerque, R.J., de Leeuw, R., Carlson, C.R., Okeson, J.P., Miller, C.S., and Andersen, A.H., 2006, “Cerebral activation during thermal stimulation of patients who have burning mouth
disorder: an fMRI study,” Pain, 122:223-34, PMID: 16632202.

de Leeuw, R., Albuquerque, R.J., Andersen, A.H., and Carlson, C.R., 2006, “Influence of estrogen on brain activation during stimulation with painful heat,” J. Oral Maxillofac. Surg., 64:158-66, PMID: 16413884.

Pager, C.T., Craft, W.W. Jr., Patch, J., and Dutch, R.E., 2006, “A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L,” Virology, 346:251-7, PMID: 16460775.

Day, B.K., Pomerleau, F., Burmeister, J.J., Huettl, P., and Gerhardt, G.A., 2006, “Microelectrode array studies of basal and potassium-evoked release of L-glutamate in the anesthetized rat brain,” J. Neurochem., 96:1626-35, PMID: 16441510.

Hascup, K.N., Rutherford, E.C., Quintero, J.E., Day, B.K., Nickell, J.R., Pomerleau, F., Huettl, P., Burmeister, J.J. and Gerhardt, G.A., 2006, “Second-by-Second Measures of L-Glutamate and Other Neurotransmitters Using Enzyme-Based Microelectrode Arrays,” In: Electrochemical Methods for Neuroscience, Adrian Michael, (Ed), Taylor & Francis Group, LLC, (Book Chapter).

Dubal, D.B., Rau, S.W., Shughrue, P.J., Zhu, H., Yu, J., Cashion, A.B., Suzuki, S., Gerhold, L.M., Bottner, M.B., Dubal, S.B., Merchanthaler, I., Kindy, M.S., and  Wise, P.M., 2006, “Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death,” Endocrinology, 147:3076-84.

Böttner, M., Dubal, D.B., Rau, S.W., Suzuki, S., and Wise, P.M., 2006, “Stroke injury in rats causes an increase in activin A gene expression which is unaffected by oestradiol treatment,” J. Neuroendocrinol., 18:97-103.

Hood, J.L., Brooks, W.H., and Roszman, T.L., 2006, “Subcellular mobility of the calpain/calpastatin network: an organelle transient,” Bioessays, 28:850-9, (Review), PMID: 16927317.

Vijitruth, R., Liu, M., Choi, D.Y., Nguyen, X.V., Hunter, R.L., and Bing, G., 2006, “Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease,” J. Neuroinflammation, 3:6, PMCID: PMC1440849.

Bing, G., Nguyen, X.V., Liu, M., Markesbery, W.R., and Sun, A., 2006, “Biophysical and biochemical characterization of intrinsic fluorescence from neurofibrillary tangles,” Neurobiol. Aging, 27:823-830, PMID: 15946772.

Wilson, M.E., Dimayuga, F.O., Reed, J.L., Curry, T.E., Anderson, C.F., Nath, A., and Bruce-Keller, A.J., 2006, “Immune modulation by estrogens: role in CNS HIV-1 infection,” Endocrine, 29:289-97, (Review), PMID: 16785604.

El-Hage, N., Wu, G., Wang, J., Ambati, J., Knapp, P.E., Reed, J.L., Bruce-Keller, A.J., and Hauser, K.F., 2006, “HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines,” Glia, 53:132-46, PMID: 16206161.

Hackler, E.A., Airey, D.C., Shannon, C.C.*, Sodhi, M.S., and Sanders-Bush, E., 2006, “5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice,” Neurosci. Res., 55:96-104. [*Shannon, maiden name (Latimer, married name)]

Schowalter, R.M., Wurth, M.A., Aguilar, H.C., Lee, B., Moncman, C.L., McCann, R.O., and Dutch, R.E., 2006, “Rho GTPase activity modulates paramyxovirus fusion protein-mediated cell-cell fusion,” Virology, 350:323-34, PMID: 16500690.

2005

Klasser, G.D., de Leeuw, R., and Albuquerque, R.J., 2005, “Self-report health questionnaire: a necessary and reliable tool in dentistry,” Gen. Dent., 53:348-54, PMID: 16252539.

de Leeuw, R., Albuquerque, R., Okeson, J., and Carlson, C., 2005, “The contribution of neuroimaging techniques to the understanding of supraspinal pain circuits: implications for orofacial pain,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 100:308-14, (Review), PMID: 16122658.

de Leeuw, R., Klasser, G.D., Albuquerque, R.J., 2005, “Are female patients with orofacial pain medically compromised?,” J. Am. Dent. Assoc., 136:459-68, PMID: 15884315.

Craft, W.W. Jr. and Dutch, R.E., 2005, “Sequence motif upstream of the Hendra virus fusion protein cleavage site is not sufficient to promote efficient proteolytic processing,” Virology, 341:130-40, PMID: 16083935.

Wise, P.M., Dubal, D.B., Rau, S.W., Brown, C.M., and Suzuki, S., 2005, “Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative,” Endocr. Rev., 26:308-12.

Magyar, J., Kiper, C., Dumaine, R., Burgess, D., Banyasz, T., and Satin, J., 2005, “Divergent action potential morphologies reveal nonequilibrium properties of human cardiac Na channels,” Cardiovasc. Res., 64:477-87.

Zhang, J., Stanton, D.M., Nguyen, X.V., Liu, M., Zhang, Z., Gash, D., and Bing, G., 2005, “Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits,” Neuroscience, 135:829-838, PMID: 16165292.

Nguyen, X.V., Masse, J., Kumar, A., Vijitruth, R., Kulik, C., Liu, M., Choi, D., Foster, T.C., Usynin, I., Bakalkin, G., and Bing, G., 2005, “Prodynorphin knockout mice demonstrate diminished age-associated
impairment in spatial water maze performance,” Behav. Brain Res., 161:254-262, PMID: 15922052.

Dimayuga, F.O., Reed, J.L., Carnero, G.A., Wang, C., Dimayuga, E.R., Dimayuga, V.M., Perger, A., Wilson, M.E., Keller, J.N., and Bruce-Keller, A.J., 2005, “Estrogen and brain inflammation: effects on microglial expression of MHC, costimulatory molecules and cytokines,” J. Neuroimmunol., 161:123-36, PMID: 15748951.

Chesney, J., Telang, S., Yalcin, A., Clem, A., Wallis, N., and Bucala, R., 2005, “Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality,” Biochem. Biophys. Res. Commun., 331:139-46, PMID: 15845370.

Meulendyke, K.A., Wurth, M.A., McCann, R.O., and Dutch, R.E., 2005 “Endocytosis plays a critical role in proteolytic processing of the Hendra virus fusion protein,” J. Virol., 79:12643-9, PMID: 16188966.

2004

Duncan, M.J., Grear, K.E., and Hoskins, M.A., 2004, “Aging and SB-269970-A, a selective 5-HT7 receptor antagonist, attenuate circadian phase advances induced by microinjections of serotonergic drugs in the hamster dorsal raphe nucleus,” Brain Res., 1008:40-8, PMID: 15081380.

Ray, K., Hines, C.S., Coll-Rodriguez, J., and Rodgers, D.W., 2004, “Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization,” J Biol. Chem., 279:20480-9.

Hood, J.L., Brooks, W.H., and Roszman, T.L., 2004, “Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus,” J. Biol. Chem., 279:43126-35, PMID: 15302874.

Magyar, J., Kiper, C.E., Dumaine, R., Burgess, D., Banyasz, T., and Satin, J., 2004, “Divergent action potential morphologies reveal nonequilibrium properties of human cardiac Na channels,” Cardiovasc. Res., 64:477-87, PMID: 15537501.

Reed, J.L., Dimayuga, F.O., Davies, L.M., Keller, J.N., and Bruce-Keller, A.J., 2004, “Estrogen increases proteasome activity in murine microglial cells,” Neurosci .Lett., 367:60-5, PMID: 15308298.

Stephens, D. and Dudley, R., 2004, “The drunken monkey hypothesis,” Natural History, 40-4.

Pager, C.T., Wurth, M.A., and Dutch, R.E., 2004, “Subcellular localization and calcium and pH requirements for proteolytic processing of the Hendra virus fusion protein,” J. Virol., 78:9154-63, PMID: 15308711.

2003

Butler, J. and Rangnekar, V.M., 2003, “Par-4 for molecular therapy of prostate cancer,” Current Drug Targets, 4:223-30, (Review), PMID: 12643472.

Pomerleau, F., Day, B.K., Huettl, P., Burmeister, J.J., and Gerhardt, G.A., 2003, “Real time in vivo measures of L-glutamate in the rat central nervous system using ceramic-based multisite microelectrode arrays,” Ann. N.Y. Acad. Sci., 1003:454-7, PMID: 14684487.

Dubal, D., 2003, “Ms Jones: reflections on aging, illness, and medicine,” Fam. Med., 35:165-6.

Hood, J.L., Logan, B.B., Sinai, A.P., Brooks, W.H., and Roszman, T.L., 2003, “Association of the calpain/calpastatin network with subcellular organelles,” Biochem. Biophys. Res. Commun., 310:1200-12, PMID: 14559243.

Urbas, A., Manning, M.W., Daugherty, A., Cassis, L.A., and Lodder, R.A., 2003, “Near-infrared spectrometry of abdominal aortic aneurysm in the apoE-/- mouse,” Anal. Chem., 75:3650-5, PMID: 14570222.

Manning, M.W., Cassis, L.A., and Daugherty, A., 2003, “Differential effects of doxycycline, a broad spectrum inhibitor of matrix metalloproteinases, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysm formation,” Arterioscler. Thromb. Vasc .Bio., 23:483-8, PMID: 12615694.

Sun, A., Liu, M., Nguyen, X.V., and Bing, G., 2003, “p38 MAP kinase is activated at early stages in Alzheimer’s disease brain,” Exp. Neurol., 183:394-405, PMID: 14552880.

Rau, S.W., Dubal, D.B., Böttner, M., Gerhold, L.M., and Wise, P.M., 2003, “Estradiol attenuates programmed cell death after stroke-like injury,” J. Neurosci., 23:11420-6.

Rau, S.W., Dubal, D.B., Böttner, M., and Wise, P.M., 2003, “Estradiol differentially regulates c-Fos after focal cerebral ischemia,” J. Neurosci., 23:10487-94.

2002

Burmeister, J.J., Pomerleau, F., Palmer, M., Day, B.K., Huettl, P., and Gerhardt, G.A., 2002, “Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS,” J. Neurosci. Meth., 119:163-171, PMID: 12323420.

Wise, P.M., Smith, M.J., Dubal, D.B., Wilson, M.E., Rau, S.W., Cashion, A.B., Böttner, M., and Rosewell, K.L., 2002, “Neuroendocrine modulation and repercussions of female reproductive aging,” Recent Prog. Horm. Res., 57:235-56.

Ray, K., Hines, C.S., and Rodgers, D.W., 2002, “Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition,” Protein Sci., 11:2237-46.

Manning, M.W., Cassis, L.A., Huang, J., Szilvassy, S.J., and Daugherty, A., 2002, “Abdominal aortic aneurysms: Fresh insights from a novel animal model of the disease,” Vasc. Med., 7:45-54, PMID: 12083734.

Manning, E.L., Crossland, J., Dewey, M.J., and Van Zant, G., 2002, “Influences of inbreeding and genetics on telomere length in mice,” Mamm. Genome, 13:234-8.

Sun, A., Nguyen, X.V., and Bing, G., 2002, “Comparative analysis of an improved thioflavin-S stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on same sections,” J. Histochem. Cytochem., 50:463-472, PMID: 11897799.

2001

Wise, P.M., Dubal, D.B., Wilson, M.E., Rau, S.W., Böttner, M., and Rosewell, K.L., 2001, “Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies,” Brain Res. Brain Res. Rev., 37:313-9.

Wise, P.M., Dubal, D.B., Wilson, M.E., Rau, S.W., and Böttner, M., 2001, “Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action,” Endocrinology, 142:969-73.

Dubal, D.B., Zhu, H., Yu, J., Rau, S.W., Shughrue, P.J., Merchenthaler, I., Kindy, M.S., and Wise, P.M., 2001, “Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury,” Proc. Natl. Acad. Sci. U.S.A., 98:1952-7.

Dubal, D.B. and Wise, P.M., 2001, “Neuroprotective effects of estradiol in middle-aged female rats,” Endocrinology, 142:43-8.

Wise, P.M., Dubal, D.B., Wilson, M.E., Rau, S.W., and Liu, Y., 2001, “Estrogens: trophic and protective factors in the adult brain,” Front. Neuroendocrinol., 22:33-66.

Daugherty, A., Manning, M.W., and Cassis, L.A., 2001, “Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis,” Br. J. Pharmacol., 134:865-70, PMC1573019.

Daugherty, A., Manning, M.W., and Cassis, L.A., 2001, “Contrasting effects of AT1 and AT2 antagonism on Angiotensin II-induced atherosclerosis and abdominal aortic aneurysms,” Br. J. Pharmacol., 134:865-70.

Amirkhosravi, A., Meyer, T., Desai, H., Amaya, M., Meyer, J., Barranco, J., and Francis, J.L., 2001, “TFPI Carboxy-Terminal Peptide Exhibits Anticoagulant Activity and Suppresses Proliferation of Melanoma and Endothelial Cells,” Blood, 98,part 2:66b, (abstract).

Sun, A., Nguyen, X.V., and Bing, G., 2001, “A novel fluorescent method for direct visualization of neurofibrillary pathology in Alzheimer’s disease,” J. Neurosci. Methods, 111:17-27, PMID: 11574116.

2000

Wise, P.M., Dubal, D.B., Wilson, M.E., and Rau, S.W., 2000, “Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury,” J. Neurocytol., 29:401-10.

Wise, P.M. and Dubal, D.B., 2000, “Estradiol protects against ischemic brain injury in middle-aged rats,” Biol. Reprod., 63:982-5.

Wilson, M.E., Dubal, D.B., and Wise, P.M., 2000, “Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors,” Brain Res., 873:235-42.

Cass, W.A., Manning, M.W., and Bailey, S.L., 2000, “Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine,” Ann. N.Y. Acad. Sci., 914:127-36, PMID: 11085315.

Daugherty, A., Manning, M.W., and Cassis, L.A., 2000, “Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice,” J. Clin. Invest., 105:1605-12, PMC300846.

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