Internal Medicine - Gastroenterology

Willem de Villiers, M.D.

Board Certifications / Certification

Internal Medicine (South Africa)
Fellow of the College of Physicians of South Africa (Internal Medicine)
American Board of Internal Medicine (ABIM)

Education

Medical School
Faculty of Medicine, University of Stellenbosch
Stellenbosch, South Africa
M.B. Ch.B. 1983

Post-Graduate Education

Internship and Residency in Internal Medicine
University of Stellenbosch
Stellenbosch, South Africa
1986 - 1991

University of Oxford
Oxford, United Kingdom
D. Phil (Oxon) 1992 - 1995

Harvard School of Public Health
Harvard University
Cambridge, MA, USA
M.H.C.M. 2006-2008

Clinical Interests and Expertise

Inflammatory Bowel Disease
Celiac Disease

Research Interests

Inflammatory Mediators in chronic inflammation macrophage scavenger receptors, lipoproteins, and inflammatory cytokines.

Grants

Moderate alcohol consumption and HDL.
NIH Clinical Investigator Award (K23).
7/99 - 6/04, $614,000.

CD36 and hepatic stellate cell activation.
NIH R21. 8/00 - 7/03, $434,600

Representative Publications

Hill DB, D'Souza NB, Lee EY, Burikhanov R, Deaciuc IV, de Villiers WJS. A role for interleukin-10 in alcohol-induced liver sensitization to bacterial lipopolysaccharide. Alcohol Clin. Exp. Res. 2002; 26: 74-82.

Gaetke LM, Oz HS, de Villiers WJS, Varilek GW, Frederich RC. The leptin defense against wasting is abolished in the IL-2 deficient model of inflammatory bowel disease. J. Nutrition 2002; 132: 893-896.

Deaciuc IV, D'Souza NB, Burikhanov R, Lee EY, Tarba CN, McClain CJ, de Villiers WJS. Epidermal growth factor protects the liver against alcohol-induced injury and sensitization to bacterial lipopolysaccharide.
Alcohol Clin. Exp. Res. 2002, 26: 864-874.

Deaciuc IV, D'Souza NB, Nikolova-Karakashian M, de Villiers WJS, Sarphie TG, McClain CJ. Gene expression of apoptosis-associated factors, cytokines and cytokine receptors in the livers of Fas antibody-treated, Kupffer cell-depleted mice: A role for Kupffer cells in Fas-mediated liver apoptosis? (Hepatol. Res., 2002, in press)

De Villiers WJS, van der Westhuyzen DR. Macrophage lipid uptake and foam cell formation. (Handbook of Experimental Pharmacology 2002, in press)

Papers Submitted

De Villiers WJS, Greaves DR, Gordon S. Exogenous and endogenous TGF-b selectively inhibits macrophage scavenger receptor expression and function. (submitted)

De Beer MC, Zhao Z, Webb NR, van der Westhuyzen DR, de Villiers WJS. Lack of a direct role for macrosialin in oxidized LDL metabolism. (submitted)

Daugherty A, de Villiers WJS, Rateri DL, Koswig N, Shah AM, de Beer F, Webb N. Relative expression of class A scavenger receptors and CD36 in mouse macrophages. (submitted)

Jiang Z, Shih D, de Villiers WJS, de Beer FC, Lusis AJ. A role for CD68 (macrosialin) in phagocytosis and clearance of apoptotic cells. (submitted)

Lan D, de Villiers WJS, Sattler W, de Beer FC, van der Westhuyzen DR. THP-1 cells internalize cholesteryl ester from oxidized LDL by a selective lipid uptake process. (submitted)

Chelvarajan RL, Doubinskaia IE, Goes S, van Willigen J, Lowery D, de Villiers WJS, Bryson JS, Bondada S. Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens. (submitted)

De Villiers WJS, Nasser MS, Deaciuc IV. 4-Hydroxy-2,3-nonenal-induced apoptosis in rat hepatic stellate cells: a mechanistic approach. (submitted)

Deaciuc IV, Doherty DE, Burikhanov R, Lee EY, Stromberg AJ, de Villiers WJS. Large scale hepatic gene profiling in a mouse model of chronic, intragastric ethanol infusion. (submitted)

Link to Publications on PubMed