Internal Medicine - Gastroenterology

Steven Shedlofsky, M.D.

Board Certifications

Internal Medicine, American Board of Internal Medicine, 1977
Gastroenterology, American Board of Internal Medicine, 1981

Clinical Interests and Expertise

Hepatitis: Hepatitis B, fatty liver, hepatitis C, liver transplantation
Disorders of iron metabolism
Porphyrias and porphyrin metabolism

Research Interests

Basic mechanisms of injury in hepatitis C
Hepatic cytochrome P450 enzymes
Drug metabolism
Iron and oxidative stress
Porphyria cutanea tarda

Representative Publications

Shedlofsky S.I., Israel B.C., McClain C. J., Hill D.B., Blouin R.A.: Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J Clin Invest 94:2209-2214, 1994.

Shedlofsky S.I. , Israel B.C., Tosheva R., Blouin R.A.: Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women. Brit J Clin Pharmacol 43:627-632, 1997.

Sinclair P.R., Gorman N., Shedlofsky S.I., Honsinger C.P., Sinclair J.F., Karagas M.R., Anderson K.E.: Ascorbic acid deficiency in porphyria cutanea tarda. J Lab Clin Med 130:197-201, 1997.

Roe A.L., Warren G., Hou G., Howard G., Shedlofsky S.I., Blouin R.A.: The effect of high dose endotoxin on CYP3A2 expression in the rat. Pharmaceut Res 15:1607-12, 1998.

Stoeckel K., Hofheinz W., Laneury J .P., Duchene P., Shedlofsky S., Blouin R.: Stability of cephalosporin prodrug esters in human intestinal juice: implications for oral bioavailability. Antimicrob Agents Chemother 42:2602-2606, 1998.

Watson A.M., Warren G., Howard G., Shedlofsky S.I., Blouin R.A.: Activities of conjugating and antioxidant enzymes following endotoxin exposure. JBiochem Mol Toxicol 13:63-69, 1999.

Poloyac S.M., Tosheva R.T., Gardner B.M., Shedlofsky S.I., Blouin, R.A.: The effect of endotoxin administration on pharmacokinetics of chlorzoxazone in humans. Clin Pharmacol Ther 66:554-62, 1999.

Shedlofsky S.I., Tosheva R.T., Snawder J.A.: Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B. Biochem Pharmacol 59:1295-1303, 2000.

Roe A.L., Poloyac S.M., Howard G., Shedlofsky S.I., Blouin R.A.: The effect of endotoxin on hepatocyte nuclear protein binding: potential implications on CYP2E1 expression in the rat. JPharm Pharmacol 53:1365-1371, 2001.

Rockich K., Tosheva R., Cunningham C., Goeger D., Blouin R., Shedlofsky S.: The effects of endotoxin administration on three putative CYP3A markers in human subjects. (submitted)

Link to Publications on PubMed