Willem de Villiers, M.D.
Board Certifications / Certification
Internal Medicine (South Africa)
Internship and Residency in Internal Medicine
University of Oxford
Harvard School of Public Health
Clinical Interests and Expertise
Inflammatory Bowel Disease
Inflammatory Mediators in chronic inflammation macrophage scavenger receptors, lipoproteins, and inflammatory cytokines.
Moderate alcohol consumption and HDL.
CD36 and hepatic stellate cell activation.
Hill DB, D'Souza NB, Lee EY, Burikhanov R, Deaciuc IV, de Villiers WJS. A role for interleukin-10 in alcohol-induced liver sensitization to bacterial lipopolysaccharide. Alcohol Clin. Exp. Res. 2002; 26: 74-82.
Gaetke LM, Oz HS, de Villiers WJS, Varilek GW, Frederich RC. The leptin defense against wasting is abolished in the IL-2 deficient model of inflammatory bowel disease. J. Nutrition 2002; 132: 893-896.
Deaciuc IV, D'Souza NB, Burikhanov R, Lee EY, Tarba CN, McClain CJ, de Villiers WJS. Epidermal growth factor protects the liver
against alcohol-induced injury and sensitization to bacterial lipopolysaccharide.
Deaciuc IV, D'Souza NB, Nikolova-Karakashian M, de Villiers WJS, Sarphie TG, McClain CJ. Gene expression of apoptosis-associated factors, cytokines and cytokine receptors in the livers of Fas antibody-treated, Kupffer cell-depleted mice: A role for Kupffer cells in Fas-mediated liver apoptosis? (Hepatol. Res., 2002, in press)
De Villiers WJS,
De Villiers WJS,
De Beer MC, Zhao Z, Webb NR, van der Westhuyzen DR, de Villiers WJS. Lack of a direct role for macrosialin in oxidized LDL metabolism. (submitted)
Daugherty A, de Villiers WJS, Rateri DL, Koswig N, Shah AM, de Beer F, Webb N. Relative expression of class A scavenger receptors and CD36 in mouse macrophages. (submitted)
Jiang Z, Shih D, de Villiers WJS, de Beer FC, Lusis AJ. A role for CD68 (macrosialin) in phagocytosis and clearance of apoptotic cells. (submitted)
Lan D, de Villiers WJS, Sattler W, de Beer FC, van der Westhuyzen DR. THP-1 cells internalize cholesteryl ester from oxidized LDL by a selective lipid uptake process. (submitted)
Chelvarajan RL, Doubinskaia IE, Goes S, van Willigen J, Lowery D, de Villiers WJS, Bryson JS, Bondada S. Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens. (submitted)
De Villiers WJS, Nasser MS, Deaciuc IV. 4-Hydroxy-2,3-nonenal-induced apoptosis in rat hepatic stellate cells: a mechanistic approach. (submitted)
Deaciuc IV, Doherty DE, Burikhanov R, Lee EY, Stromberg AJ, de Villiers WJS. Large scale hepatic gene profiling in a mouse model of chronic, intragastric ethanol infusion. (submitted)
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