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Internal Medicine - Gastroenterology

Internal Medicine

Division of
Digestive Diseases
and Nutrition


Terrence Barrett, MD, FACP

Board Certifications

Internal Medicine, American Board of Internal Medicine, 1986
Gastroenterology, American Board of Internal Medicine, 1989


Bachelor of Science
University of Notre Dame
Notre Dame, Indiana

Doctor of Medicine
University of Illinois
Chicago, Illinois

Post-Graduate Education

Internship and Residencies
Rush Presbyterian St. Luke's Hospital
Chicago, Illinois

University of Chicago
Chicago, Illinois

Research Fellowships
Gastroenterology - Eugene Chang, MD
University of Chicago
Chicago, Illinois

Immunology - Jeffrey Bluestone, PhD
University of Chicago
Chicago, Illinois



Professional Memberships

American Association of Immunology, Member, 7/91
New York Academy of Science, Member, 3/95
American Medical Association, Member, 6/79
American College of Physicians, Fellow, 7/91
American Gastroenterology Association, Member, 7/86
Chicago Society of Gastroenterology, Member, 7/86
Gastroenterology Research Group, Member, 7/91
Society for Mucosal Immunology, Member 7/91
Crohn's and Colitis Foundation of America, Member, 7/90
Midwest Gut Club, Councilor, 7/91
American College of Gastroenterology, Member, 7/95
American Society for Clinical Research, Member, 5/96
American Society for Clinical Investigation, Member, 2/03

Clinical Interests and Expertise

Inflammatory bowel disease

Research Interests

Inflammatory bowel disease pathogenesis and treatment
Mechanisms of inflammation-induced intestinal cancer
Intestinal epithelial stem cell biology
Mucosal T cell immunology

Representative Publications

He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L.  PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet. 2007 Feb;39(2):189-98. Epub 2007 Jan 21. 

Brown JB, Lee G, Managlia E, Grimm GR, Dirisina R, Goretsky T, Cheresh P, Blatner NR, Khazaie K, Yang GY, Li L, and Barrett TA. Mesalamine Inhibits Epithelial beta-Catenin Activation in Chronic Ulcerative Colitis. Gastroenterology. 2010 February;138(2):595-605.e1-3 Epub 2009 Oct 29. Doi: 10.1053/j.gastro.2009.10.038 PMID: 19879273. PMCID:PMC2819654.

Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, and Barrett TA. Phosphoinositide 3-Kinase Signaling Mediates beta-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis. Gastroenterology. 2010 Sep; 139 (3):869-81. PMID: 20580720 PMCID: PMC2930080.

Dirisina R, Katzman RB, Goretsky T, Managlia E, Mittal N, Williams DB, Qiu W, Yu J, Chandel NS, Zhang L, Barrett TA. P53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology. 2011 Sep;141(3):1036-45. Epub 2011 May 27. PMID: 21699775.

Managlia, E, Katzman, RB, Brown, J and Barrett TA.  Anti-oxidant properties of mesalamine in colitis inhibit PI3K signaling in progenitor cells. Inflamm Bowel Dis. 2013 (Accepted In Press, IBD-12-0510.R3).

More Publications on PubMed

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