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Internal Medicine - Gastroenterology

Internal Medicine

Division of
Digestive Diseases
and Nutrition

CONTACT

Steven Shedlofsky, M.D.

Photo of Dr. Shedlofsky

Board Certifications

Internal Medicine, American Board of Internal Medicine, 1977
Gastroenterology, American Board of Internal Medicine, 1981

Clinical Interests and Expertise

Hepatitis: Hepatitis B, fatty liver, hepatitis C, liver transplantation
Disorders of iron metabolism
Porphyrias and porphyrin metabolism

Research Interests

Basic mechanisms of injury in hepatitis C
Hepatic cytochrome P450 enzymes
Drug metabolism
Iron and oxidative stress
Porphyria cutanea tarda

Representative Publications

Shedlofsky S.I., Israel B.C., McClain C. J., Hill D.B., Blouin R.A.: Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J Clin Invest 94:2209-2214, 1994.

Shedlofsky S.I. , Israel B.C., Tosheva R., Blouin R.A.: Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women. Brit J Clin Pharmacol 43:627-632, 1997.

Sinclair P.R., Gorman N., Shedlofsky S.I., Honsinger C.P., Sinclair J.F., Karagas M.R., Anderson K.E.: Ascorbic acid deficiency in porphyria cutanea tarda. J Lab Clin Med 130:197-201, 1997.

Roe A.L., Warren G., Hou G., Howard G., Shedlofsky S.I., Blouin R.A.: The effect of high dose endotoxin on CYP3A2 expression in the rat. Pharmaceut Res 15:1607-12, 1998.

Stoeckel K., Hofheinz W., Laneury J .P., Duchene P., Shedlofsky S., Blouin R.: Stability of cephalosporin prodrug esters in human intestinal juice: implications for oral bioavailability. Antimicrob Agents Chemother 42:2602-2606, 1998.

Watson A.M., Warren G., Howard G., Shedlofsky S.I., Blouin R.A.: Activities of conjugating and antioxidant enzymes following endotoxin exposure. JBiochem Mol Toxicol 13:63-69, 1999.

Poloyac S.M., Tosheva R.T., Gardner B.M., Shedlofsky S.I., Blouin, R.A.: The effect of endotoxin administration on pharmacokinetics of chlorzoxazone in humans. Clin Pharmacol Ther 66:554-62, 1999.

Shedlofsky S.I., Tosheva R.T., Snawder J.A.: Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B. Biochem Pharmacol 59:1295-1303, 2000.

Roe A.L., Poloyac S.M., Howard G., Shedlofsky S.I., Blouin R.A.: The effect of endotoxin on hepatocyte nuclear protein binding: potential implications on CYP2E1 expression in the rat. JPharm Pharmacol 53:1365-1371, 2001.

Rockich K., Tosheva R., Cunningham C., Goeger D., Blouin R., Shedlofsky S.: The effects of endotoxin administration on three putative CYP3A markers in human subjects. (submitted)

Link to Publications on PubMed

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