Phone:
(859) 323-5575
Fax:
(859) 257-8860
Dr. Willem de Villiers
Willem J.S. de Villiers, M.D. Ph.D.
Board Certifications / Certification
Internal Medicine
(South Africa)
Fellow of the
College of Physicians of South Africa (Internal
Medicine)
American Board of
Internal Medicine (ABIM)
Education
Medical School
Faculty of Medicine,
University of Stellenbosch
Stellenbosch, South
Africa
M.B. Ch.B. 1983
Post-Graduate Education
Internship and
Residency in Internal
Medicine
University of
Stellenbosch
Stellenbosch, South
Africa 1986 - 1991
University of Oxford
Oxford, United
Kingdom
D. Phil (Oxon) 1992
- 1995
Clinical Interests and Expertise
Inflammatory Bowel
Disease
Celiac Disease
Research
Interests
Inflammatory Mediators in
chronic inflammation
macrophage scavenger receptors,
lipoproteins, and
inflammatory cytokines.
Grants
Moderate alcohol
consumption and HDL.
NIH Clinical Investigator
Award (K23).
7/99 - 6/04,
$614,000.
CD36 and hepatic
stellate cell activation.
NIH R21. 8/00 -
7/03, $434,600
Representative Publications
Hill DB, D'Souza NB, Lee EY, Burikhanov R, Deaciuc IV, de Villiers WJS. A role for interleukin-10 in alcohol-induced liver sensitization to bacterial lipopolysaccharide. Alcohol Clin. Exp. Res. 2002; 26: 74-82.
Gaetke LM, Oz HS, de Villiers WJS, Varilek GW, Frederich RC.The leptin defense against wasting is abolished in the IL-2 deficient model of inflammatory bowel disease. J. Nutrition 2002; 132: 893-896.
Deaciuc IV, D'Souza NB,
Burikhanov R, Lee EY, Tarba
CN, McClain CJ, de Villiers
WJS. Epidermal growth
factor protects the liver
against alcohol-induced
injury and sensitization to
bacterial lipopolysaccharide.
Alcohol Clin. Exp. Res. 2002, 26: 864-874.
Deaciuc IV, D'Souza NB, Nikolova-Karakashian M, de Villiers WJS, Sarphie TG, McClain CJ. Gene expression of apoptosis-associated factors, cytokines and cytokine receptors in the livers of Fas antibody-treated, Kupffer cell-depleted mice: A role for Kupffer cells in Fas-mediated liver apoptosis? (Hepatol. Res., 2002, in press)
De Villiers WJS,
Papers Submitted
De Villiers WJS,
De Beer MC, Zhao Z, Webb NR, van der Westhuyzen DR, de Villiers WJS. Lack of a direct role for macrosialin in oxidized LDL metabolism. (submitted)
Daugherty A, de Villiers WJS, Rateri DL, Koswig N, Shah AM, de Beer F, Webb N. Relative expression of class A scavenger receptors and CD36 in mouse macrophages. (submitted)
Jiang Z, Shih D, de Villiers WJS, de Beer FC, Lusis AJ. A role for CD68 (macrosialin) in phagocytosis and clearance of apoptotic cells. (submitted)
Lan D, de Villiers WJS, Sattler W, de Beer FC, van der Westhuyzen DR. THP-1 cells internalize cholesteryl ester from oxidized LDL by a selective lipid uptake process. (submitted)
Chelvarajan RL, Doubinskaia IE, Goes S, van Willigen J, Lowery D, de Villiers WJS, Bryson JS, Bondada S. Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens. (submitted)
De Villiers WJS, Nasser MS, Deaciuc IV. 4-Hydroxy-2,3-nonenal-induced apoptosis in rat hepatic stellate cells: a mechanistic approach. (submitted)
Deaciuc IV, Doherty DE, Burikhanov R, Lee EY, Stromberg AJ, de Villiers WJS. Large scale hepatic gene profiling in a mouse model of chronic, intragastric ethanol infusion. (submitted)
