Zhenheng Guo, Ph.D.
Associate Professor, Division of Endocrinology and Molecular Medicine
Core Faculty Member, Saha Cardiovascular Research Center
Contact Information |
Training and Publications |
| University of Kentucky |
| 515 Charles T. Wethington Building |
Publication Listing on PubMed |
| 900 South Limestone Street |
|
| Lexington, KY 40536-0200 |
|
| Telephone: (859) 323-4933 ext. 81416 |
|
| Fax: (859) 257-3646 |
|
|
Email |
| |
Research Topics |
|
|
Hypertension
Restenosis
Aortic Aneurysm
Circadian
Diabetic vascular complication
|
| |
Research Interests |
|
|
With a long-term goal of identifying novel therapeutic targets for treatment of cardiovascular diseases, Dr. Guo’s research
has focused on the role of vascular smooth muscle cells (VSMC) in cardiovascular diseases. In particular, Dr. Guo is interested in a
specific protein or enzyme, calcium independent phospholipase A2β (iPLA2β) that expresses in VSMC and is implicated in the
pathogenesis of hypertension, restenosis, aortic aneurysm, and diabetes vascular complications.
The current research projects in Dr. Guo’s laboratory follow:
- The role of VSMC iPLA2β in transcriptional regulation of regulator of G protein signaling 2 (RGS2) by angiotensin II (Ang II) in cultured VSMC
- The role of VSMC iPLA2β in diabetes-associated vascular smooth muscle hypercontractility and hypertension
- The role of VSMC iPLA2β in initiation and early progression of vascular inflammation and neointima formation
- The role of VSMC mineralocorticoid receptor (MR) in deoxycorticosterone acetate (DOCA)- or aldosterone-salt-induced aortic aneurysms
- The role of VSMC BMAL1 in regulation of vascular smooth muscle contractile variability and blood pressure circadian rhythm
| | 
