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Internal Medicine - Endocrinology





Zhenheng Guo, Ph.D.

Picture of Dr. Guo   

          Associate Professor, Division of Endocrinology and Molecular Medicine
          Core Faculty Member, Saha Cardiovascular Research Center


Contact Information

Training and Publications

University of Kentucky
515 Charles T. Wethington Building Publication Listing on PubMed
900 South Limestone Street
Lexington, KY 40536-0200  
Telephone: (859) 323-4933 ext. 81416  
Fax: (859) 257-3646  

Research Topics

Aortic Aneurysm
Diabetic vascular complication


Research Interests

With a long-term goal of identifying novel therapeutic targets for treatment of cardiovascular diseases, Dr. Guo’s research has focused on the role of vascular smooth muscle cells (VSMC) in cardiovascular diseases. In particular, Dr. Guo is interested in a specific protein or enzyme, calcium independent phospholipase A2β (iPLA2β) that expresses in VSMC and is implicated in the pathogenesis of hypertension, restenosis, aortic aneurysm, and diabetes vascular complications.

The current research projects in Dr. Guo’s laboratory follow:

  1. The role of VSMC iPLA2β in transcriptional regulation of regulator of G protein signaling 2 (RGS2) by angiotensin II (Ang II) in cultured VSMC
  2. The role of VSMC iPLA2β in diabetes-associated vascular smooth muscle hypercontractility and hypertension
  3. The role of VSMC iPLA2β in initiation and early progression of vascular inflammation and neointima formation
  4. The role of VSMC mineralocorticoid receptor (MR) in deoxycorticosterone acetate (DOCA)- or aldosterone-salt-induced aortic aneurysms
  5. The role of VSMC BMAL1 in regulation of vascular smooth muscle contractile variability and blood pressure circadian rhythm

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Page last updated Monday, September 09, 2013