Internal Medicine - Endocrinology

Office Address:
CT Wethington Health Sciences  0200
Office Rm. 535 / Lab: 539 900 S. Limestone St.
Lexington, KY 40536-0200
(859) 323-4933 x81385
fax: (859) 257-3646

nrwebb1@email.uky.edu

Research Interests

• Lipoprotein Metabolism
• Atherosclerosis
• HDL Receptor SR-BI
• Viral vector mediated gene transfer

The risk of developing coronary heart disease is directly related to plasma levels of LDL cholesterol and inversely correlated with the concentration of HDL cholesterol. My laboratory focuses on further understanding HDL metabolism, and the mechanisms by which HDL provides protection against atherosclerotic disease. Our approach is to use recombinant viral vectors to manipulate the expression of candidate genes in various mouse models.  We also use cell culture systems to study the interaction of HDLs with lipoprotein receptors in vitro.

Research

Project title: Scavenger Receptor B-I:  Distinct Functional Domains
Sponsor: American Heart Association
PI: Nancy Webb
Co-investigators:
Total Funding (dates) 
$65,000 per annum (2001-2004)