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Delta Dental
of Kentucky Clinical Research Center (DDKCRC)
provides a state of the art facility to support
planning, execution and completion of clinical
research studies. Our close proximity and
collaborations with UK's General Clinical Research
Center and Clinical Research Organization provides
a unique opportunity for carrying out clinical
research involving multi-disciplinary teams of
dentists, physicians, and healthcare ancillaries.
DDKCRC has a team of clinical research
coordinators experienced in NIH-funded,
multidisciplinary, multi-center, clinical trials
and industry sponsored FDA phase II-IV clinical
studies. It is supported by a team of basic
scientists in a fully equipped core that provides
opportunities for translational research, FDA
phase I studies, and laboratory support of
clinical trials. The commitment and support of
Delta Dental of Kentucky and UK has provided
previously unavailable opportunities for the
citizens of Kentucky to participate in outstanding
clinical research trials in oral healthcare.
DDKCRC is already having an impact on the oral
health and general well being of the community
through its studies of preterm birth, gestational
diabetes, cardiovascular disease, and new
treatments for oral disease. We are committed to
expanding our translational and clinical research
so as to extend the benefits of improved oral
health to all Kentuckians. |
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Clinical
Core |
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2000
square feet of clinical research space
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3
fully equipped examination rooms/dental
operatories
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Each
operatory has digital radiography, Periotron
for GCF and salivary measures, internet
connected tablet PC and laptop PC for data
entry and immediate download, all necessary
instrumentation for clinical intervention
studies.
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Coordinator
offices with internet connected computers,
fax, secure record storage
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Conference
room for study related meetings and CRF
review
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Laboratory
Core |
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5000
square feet basic science laboratory
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Full-time
research associates and research assistants
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Assays
of serum, gingival crevicular fluid and saliva for
inflammatory markers and markers of oral and
systemic disease
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Microbiologic
assessment by culture techniques, and molecular
analyses
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Antibiotic
susceptibility testing for oral bacteria
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Linkage
with genetic and microarray analysis capabilities
for mammalian and bacterial gene expression
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Potential
for use of rat, mouse, and non-human primate
models for Phase 1 studies.
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Areas of
Research |
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effects
of periodontal disease/chronic infections on
preterm birth
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effects
of gestational diabetes on periodontal
disease/chronic infections and negative birthing
outcomes
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effects
of periodontal disease on myocardial infarction
and stroke
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effects
of nutrition on periodontal disease and response
to treatment
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non-surgical
treatment of periodontal disease
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use
of saliva for the diagnosis of oral and systemic
conditions
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detection,
diagnosis and treatment of viral infections
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effects
of tooth extraction on systemic health
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wisdom
teeth as a source of infection and inflammation
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development
and comparison of oral surgical techniques
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