< backPublications of Alan Daugherty, Ph.D., D.Sc.

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  1. Daugherty, A. (1981). Myocardial metabolism of calcium and cyclic nucleotides. Ph.D. thesis. University of Bath, England.
  2. Daugherty, A, and B. Woodward. (1981). Calcium and calcium slow-channel antagonists on cyclic nucleotide levels in the isolated rat heart. Journal of Molecular and Cellular Cardiology. 13: 843-854.
  3. Daugherty, A. and B. Woodward. (1985). Carbachol and cyclic GMP on the vulnerability to ventricular fibrillation is the rat isolated heart. British Journal of Pharmacology. 85: 621-627.
  4. Daugherty, A., L.G. Lange, B.E. Sobel, and G. Schonfeld. (1985). Aortic accumulation and plasma clearance of b-VLDL and HDL: Effects of diet-induced hypercholesterolemia in rabbits. Journal of Lipid Research. 26: 955-963.
  5. Daugherty, A., S.R. Thorpe, L.G. Lange, B.E. Sobel, and G. Schonfeld. (1985). Loci of catabolism of b-very low density lipoprotein in vivo delineated with a residualizing label: 125I-dilactitol tyramine. Journal of Biological Chemistry. 260: 14564-14570.
  6. Daugherty, A., K. N. Frayn, W. S. Redfern and B. Woodward. (1986). The role of catecholamines in the production of ischaemic-induced ventricular arrhythmias in the rat in vivo and in vitro. British Journal of Pharmacology. 87: 265-277.
  7. Daugherty, A., G. Schonfeld, B.E. Sobel and L.G. Lange. (1986). Metabolism of very low density lipoproteins after cessation of cholesterol feeding in rabbits: A factor potentially contributing to the slow regression of atheromatous plaques. Journal of Clinical Investigation. 77: 1108-1115.
  8. Fields, L., A. Daugherty and S.R. Bergmann. (1986). Effect of fatty acid on performance and lipid content of hearts from diabetic rabbits. American Journal of Physiology. 250: H1079-H1085.
  9. Daugherty, A., D.L. Rateri, G. Schonfeld and B.E. Sobel. (1987). Inhibition of cholesteryl ester deposition in macrophages by calcium entry blockers. An effect dissociable from calcium entry blockade. British Journal of Pharmacology. 91: 113-118.
  10. Tilton, R. G., P.A. Cole, J.D. Zions, A. Daugherty, K.B. Larson, S.P. Sutera, C. Kilo and J. R. Williamson. (1987). Increased ischemia-reperfusion injury to the heart associated with short term, diet-induced hypercholesterolemia in rabbits. Circulation Research. 60: 551-559.
  11. Daugherty A., K., Oida, B.E. Sobel and G. Schonfeld. (1988). The dependence of metabolic and structural heterogeneity of cholesteryl ester-rich very low density lipoproteins on the duration of cholesterol feeding in rabbits. Journal of Clinical Investigation. 82: 562-570.
  12. Cole, T. G., R. T. Kitchens, A. Daugherty and G. Schonfeld. (1988). An improved method of separation of triglyceride-rich lipoproteins by fast protein liquid chromatography. Pharmacia Comminuque. 4: 4-7.
  13. Daugherty, A., B.S. Zweifel, B.E. Sobel and G. Schonfeld. (1988). Isolation of low density lipoproteins from atherosclerotic vascular tissue of Watanabe Heritable Hyperlipidemic rabbits. Arteriosclerosis. 8: 768-777.  PDF file
  14. Tilton, R.G., A. Daugherty, S.P. Sutera, K.B. Larson, M.P. Land, D.L. Rateri, C. Kilo, and J. R. Williamson. (1989). Diabetes and high-fat diets block myocyte contracture and vascular resistance changes but increase microvascular permeability during reflow after ischemia in isolated rabbit hearts. Diabetes. 38: 1484-1491.
  15. Daugherty, A., B. Zweifel, and G. Schonfeld. (1989). Probucol attenuates the development of atherosclerosis in cholesterol-fed rabbits. British Journal of Pharmacology. 98: 612-618.
  16. Daugherty, A., N.N. Becker, L.A. Scherrer, B.E. Sobel, J.J.H. Ackerman, J.W. Baynes and S.R. Thorpe. (1990) Non-invasive detection of protein metabolism by n.m.r. spectroscopy. Application of a novel 19F-residualizing label. Biochemical Journal. 264: 829-835.
  17. Parhoffer, K.G., A. Daugherty, M. Kinoshita, and G. Schonfeld. (1990). Enhanced clearance from plasma of low density lipoproteins containing a truncated apolipoprotein, B-90. Journal of Lipid Research. 31: 2001-2007.
  18. Moerlein, S.M., A. Daugherty, B.E. Sobel, and M.J. Welch. (1991) Imaging tissue metabolic activity with gallium-68 and indium-111 labeled low-density lipoprotein. Journal of Nuclear Medicine. 32: 300-307.
  19. Daugherty, A., B.S. Zweifel, and G. Schonfeld. (1991) Probucol retards the progression of established aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits. British Journal of Pharmacology. 103: 1013-1018.  PDF file
  20. Daugherty, A., and D.L. Rateri. (1991) Failure of the intracellular itinerary of b-very low density lipoproteins to augment cholesterol esterification in macrophages from Watanabe heritable hyperlipidemic rabbits. Journal of Biological Chemistry. 266: 17269-17275.   PDF file
  21. Daugherty, A, and D.L. Rateri. (1991) Heterogeneity of very low density lipoproteins: Factors influencing the ability of specific subfractions to modulate cholesterol metabolism in macrophages in vitro. Coronary Artery Disease. 2: 775-789.  PDF file
  22. Daugherty, A., M.R Kilbourn, C.S. Dence, B.E. Sobel, and S.R. Thorpe. (1992) Development of a residualizing label for detection of protein metabolism by positron emission tomography. Nuclear Medicine and Biology. 19: 411-416
  23. Ord, J.M., J.P. Hasapes, A. Daugherty, S.R. Bergmann, S.R. Thorpe, and B.E. Sobel. (1992) Noninvasive detection of thrombi using tissue-type plasminogen activator coupled to a residualizing radiolabel. Circulation. 85: 288-297.
  24. Daugherty, A. and D.L. Rateri. (1992) Kinetics of tissue metabolism of b-very low density lipoproteins disparate rates of tissue accumulation during both normal and hypercholesterolemic states. Life Science Advances - Biochemistry. 10: 167-171.  PDF file
  25. Hasapes, J.P., A. Daugherty, J.E. Saffitz, and B.E. Sobel. (1992) Determination of the tissue distribution of radiolabeled congeners of t-PA and its modification for improved clot imaging. Coronary Artery Disease. 3: 641-649.  PDF file
  26. Mankowitz, K., R. Seip, A. Daugherty, C.F. Semenkovich, A. Daugherty, and G. Schonfeld. (1992) Short term detraining adversely affects both fasting and post-prandial lipoproteins, including Lp(a). Atherosclerosis. 95: 181-189.  PDF file
  27. Meeh, L.A., J.J.H. Ackerman, S.R. Thorpe, and A. Daugherty. (1992) Quantification of the accumulation and degradation of b-very low density lipoproteins in vivo using a 19F-containing residualizing label and N.M.R. spectroscopy. Biochemical Journal. 286: 785-792.  PDF file
  28. Wickline, S.A., R.A. Shapard, and A. Daugherty. (1993) Quantitative ultrasonic tissue characterization of atherosclerosis. Arteriosclerosis and Thrombosis. 13: 1543-1550.
  29. Baumann, D.S., M. Doblas, G. Schonfeld, G.A. Sicard and A. Daugherty. (1994) Probucol reduces the cellularity of aortic intimal thickening at anastomotic regions adjacent to prosthetic grafts in cholesterol-fed rabbits. Arteriosclerosis and Thrombosis. 14: 162-167.  PDF file
  30. Baumann, D.S., M. Doblas, A. Daugherty, G. A. Sicard, and G. Schonfeld. (1994). The role of cholesterol accumulation in prosthetic vascular graft anastomotic intimal hyperplasia. Journal of Vascular Surgery. 19: 435-445.  PDF file
  31. Daugherty, A., J.L. Dunn, D.L. Rateri, and J.W. Heinecke. (1994). Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions Journal of Clinical Investigation. 94:437-444.  PDF file
  32. Daugherty, A. and D.L. Rateri. (1994). Low density lipoprotein receptor-related protein/a2-macroglobulin receptor is abundant in atherosclerotic lesions: Comparison of distribution in lesions formed in cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits. Arteriosclerosis and Thrombosis. 14:2107-2024.  PDF file
  33. Noda-Heiny, H., A. Daugherty, and B.E. Sobel. (1995). Augmented urokinase receptor expression in atheroma. Arteriosclerosis, Thrombosis, and Vascular Biology. 15:37-43.  PDF file
  34. Roselaar, S.E., G. Schonfeld, and A. Daugherty. (1995) Suppression of cell-mediated immunity enhances development of atherosclerosis in cholesterol-fed rabbits. Journal of Clinical Investigation. 96:1389-1394.  PDF file
  35. Shaish, A., A. Daugherty, F. O=Sulivan, G. Schonfeld, and J.W. Heinecke. (1995) Beta carotene inhibits atherosclerosis in cholesterol-fed rabbits. Journal of Clinical Investigation. 96:2075-2082.
  36. Roselaar, S.E., P. Kakkanathu, and A. Daugherty. (1996) Lymphocyte populations in atherosclerotic lesions of apoE -/- and LDL receptor -/- mice. Decreasing density with disease progression. Arteriosclerosis, Thrombosis, and Vascular Biology. 16:1013-1018.  PDF file
  37. Fagan, A.M., G. Bu., Y. Sun, A. Daugherty, and D.M. Holtzman. (1996) Apolipoprotein E -containing high-density lipoprotein promotes neurite outgrowth and is a ligand for the low-density lipoprotein receptor-related protein. Journal of Biological Chemistry. 271: 30121-30125.  PDF file
  38. Cornicelli, J.A., K. Welch, B.J. Auerbach, S.J. Feinmark, and A. Daugherty. (1996) Mouse peritoneal macrophages contain abundant w-6 lipoxygenase activity that is independent of interleukin-4. Arteriosclerosis, Thrombosis, and Vascular Biology. 16:1488-1494.  PDF file
  39. Sendobry, S.M., J.A. Cornicelli, K. Welch, T. Bocan, B. Tait, B.K. Trivedi, N. Colbry, R.D. Dyer, S.J. Feinmark, and A. Daugherty. (1997) Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. British Journal of Pharmacology. 120:1199-1206.  PDF file
  40. Daugherty, A., E. Puré, D. Delfel-Butteiger, S. Chen, J. Leferovich, S. E. Roselaar, and D.J. Rader. (1997) Total immune deficiency does not affect extent of atherosclerosis in apolipoprotein E-/- mice despite changes in macrophage phenotype and MDA-LDL autoantibody titers. Journal of Clinical Investigation. 100: 1575-1580.  PDF file
  41. Daugherty, A., J.A. Cornicelli, K. Welch, S.M. Sendobry, and D.L. Rateri. (1997) Scavenger receptors are present on aortic endothelial cells in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 2369-2375.  PDF file
  42. Roselaar, S.E., and A. Daugherty. (1997) Lipopolysaccharide decreases scavenger receptor mRNA abundance in vivo. Journal of Interferon and Cytokine Research. 17: 573-579.  PDF file
  43. Bocan, M.A., W.S. Rosebury, S.B. Mueller, S. Kuchera, K. Welch, A. Daugherty, and J.A. Cornicelli. (1998) A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis. 136: 203-216.  PDF file
  44. Semenkovich, C.F., L. Coleman, and A. Daugherty. (1998) Effect of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice. Journal of Lipid Research. 39: 1141-1151.  PDF file
  45. Sendobry, S.M., J.A. Cornicelli, K. Welch, M.J. Grusby, and A. Daugherty. (1998) Absence of T lymphocyte_derived cytokines fails to diminish macrophage 12/15 lipoxygenase expression in vivo. Journal of Immunology. 161:1477-1482.  PDF file
  46. Roselaar, S.E. and A. Daugherty. (1998) Apolipoprotein E deficiency impairs innate immune responses to Listeria monocytogenes in vivo. Journal of Lipid Research. 39:1740-1743.  PDF file
  47. Cassis L., and A. Daugherty. (1999) Chronic angiotensin II infusion promotes atherogenesis in LDL receptor -/- mice. Annals of New York Academy of Sciences. 892:108-118.  PDF file
  48. Cornicelli, J.A., D. Delfel-Butteiger, D.L. Rateri, K. Welch, and A. Daugherty. (2000) Interleukin-4 stimulates scavenger receptor synthesis and activity in cultured macrophages. Journal of Lipid Research. 41:376-383.  PDF file
  49. Whitman, S.C., A. Daugherty, and S.R. Post. (2000) Attenuation of G protein function decreases modified LDL uptake by macrophages. Journal of Lipid Research. 41:807-813.  PDF file
  50. Daugherty, A. and L.A. Cassis. (2000) Angiotensin promotes rapid formation of atherosclerotic lesions and aneurysms in apolipoprotein E -/- mice. Journal of Clinical Investigation. 105:1605-1612.  PDF file
  51. Daugherty, A., S.C. Whitman, A.E. Block, and D.L. Rateri. (2000) Polymorphism of class A scavenger receptors in C57BL/6 mice. Journal of Lipid Research. 41: 1568-1577.  PDF file
  52. Whitman, S.C., P. Ravisankar, Elam, H., and A. Daugherty. (2000) Exogenous interferon-( enhances atherosclerosis in apolipoprotein E-/- mice. American Journal of Pathology. 157: 1819 - 1824.  PDF file
  53. Whitman, S.C., A. Daugherty, and S.R. Post. (2000) Acute regulation of LDL receptor-mediated VLDL metabolism by macrophage-colony stimulating factor through a Gi/o mediated signaling mechanism. Journal of Biological Chemistry. 275: 35807-35813.  PDF file
  54. Gairola, C.G., and A. Daugherty. Sidestream cigarette smoke accelerates atherosclerosis in apolipoprotein E-/- mice. Atherosclerosis. 156: 49-56. PDF file
  55. Lee Y.W., H. Kuhn, B. Hennig, A. Daugherty, and M. Toborek. Interleukin-4 mediated transcriptional regulation of 15-lipoxygenase gene expression in human endothelial cells. Journal of Biological Chemistry. 42: 783-791.  PDF file
  56. Daugherty, A., N. Kosswig, J.A. Cornicelli, S.C. Whitman, S. Wolle, D.L. Rateri. (2001) Macrophage specific expression of class A scavenger receptors enhances granuloma formation in the absence of increased lipid deposition. Journal of Lipid Research. 42: 1049-1055. PDF file
  57. Hansen, P.R., M. Chew, J. Zhou, A. Daugherty, N.H.H. Heegaard, P. Jensen, S. Mouritsen, and E. Falk. (2001) Freunds adjuvant alone is antiatherogenic in apoE-deficient mice and specific immunization against TNF-alpha confers no additional benefit. Atherosclerosis. 158: 87-94. PDF file
  58. Daugherty, A, M.W. Manning, and L. A . Cassis. (2001) Contrasting effects of AT1 and AT2 antagonism on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. British Journal of Pharmacology. 134: 865-870 PDF file
  59. Whitman, S.C., P. Ravisankar, P., and A. Daugherty. (2002) Interleukin-18 enhances atherosclerosis in apolipoprotein E -/- mice through release of interferon-( Circulation Research. 10.1161/hh0202.105292. PDF file
  60. King, V.L., S.J. Szilvassy, and A. Daugherty. (2002) Interleukin-4 deficiency in LDL_receptor-/- mice fed a high fat diet decreases atherosclerotic lesion formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 456-461. PDF file
  61. King, V.L., S.J. Szilvassy, and A. Daugherty. (2002) Interleukin- 4 deficiency promotes gall stone formation. Journal of Lipid Reseach. 43: 768-771 PDF file
  62. Whitman, S.C., P. Ravisankar, H. Elam, A. Daugherty. (2002) Interferon-gamma deficiency exerts gender specific effects on atherogenesis in apolipoprotein E -/- mice. Journal of Interferon and Cytokine Research. 22: 661-670. PDF file
  63. Hennig B., P. Meerarani, R. Slim, M. Toborek, A. Daugherty, A. Silverstone, and L.W. Robertson. (2002) Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol. Sci. 181: 174-183. PDF file
  64. Whitman, S.C, D.L. Rateri, S.J. Szilvassy, J.A. Cornicelli, and A. Daugherty. (2002) Macrophage specific expression of class A scavenger receptors decreases atherosclerosis in LDL receptor -/- mice. Journal of Lipid Research. 43: 1201-1208 PDF file
  65. Webb, N.R., A. Daugherty, M.C. de Beer, M.S. Kindy, D. van der Westhuyzen, and F.C. de Beer. (2002) The scavenger receptor BI (SR-BI) mediates clearance of apoB-containing lipoproteins in apoE-deficient mice. Journal of Lipid Research. 43: 1421-1428 PDF file
  66. Webb, N.R., M.A. Bostrom, S.J. Szilvassy, D.R. van der Westhuyzun, A. Daugherty, and F.C. de Beer. (2003) Macrophage-expressing Group IIA sPLA2 increases atherosclerotic lesion formation in LDL receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 43:1421-1428. PDF file
  67. Manning, M.W., L.A. Cassis, and A. Daugherty. Differential effects of doxycycline, a broad spectrum inhibitor of matrix metalloproteinases, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysm formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 23:468-474. PDF file
  68. Sundell, C.L, P.K. Somers, C.Q. Meng., L. K. Hoong, K-L. Suen, R.R. Hill, L.K. Landers, A. Chapman, L.K. Ollif, C. Phanhthourath, C. Kunsch, A. Daugherty, U. Saxena, M.A. Wasserman, and R. M. Medford AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and anti-atherosclerotic agent. Journal of Pharmacology and Experimental Therapeutics. 305: 1116-1123. PDF file
  69. Chew, M., J. Zhou, A. Daugherty, T. Eriksson, S. Ellerman-Eriksen, P.R. Hansen, and E. Falk. (2003) Thalidomide inhibits early atherogenesis in apoE deficient mice. APMIS.: acta pathologica, microbiologica et immunologica Scandinavica 2003; 111 (Suppl 109): 113-116.
  70. Urbas, A, M. W. Manning, A. Daugherty, L.A. Cassis, and R.A Lodder. (2003) Near-infrared spectrometry of abdominal aortic aneurysm in the apoE -/- mouse. Analytical Chemistry. 75: 3318-3323 PDF file
  71. Saraff, K., F. Babamusta, L.A. Cassis, and A. Daugherty. (2003) Aortic dissection precedes formation of aneurysms and atherosclerosis in AngII-infused apoE deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1621-1625. PDF file
  72. Kosswig, N., A. Daugherty, and S.R. Post. (2003) Class A scavenger receptor mediated adhesion and internalization require distinct cytoplasmic domains. Journal of Biological Chemistry. 278: 34219-34225 PDF file
  73. Lyngdorf, L.G., S. Gregersen, A. Daugherty, and E. Falk. (2003) Paradoxical reduction of atherosclerosis in apoE-deficient mice with obesity-related type 2 diabetes. Cardiovascular Research. 59: 854-862 PDF file
  74. Cassis, L.A., J. Huang, M.C. Gong, and A. Daugherty. (2004) Role of metabolism and receptor responsiveness in the attenuated responses to angiotensin II in mice compared to rats. Regulatory Peptides. 117: 107-116. PDF file
  75. Whitman, S.C., D.L. Rateri, S.J. Szilvassy, W. Yokoyama, and A. Daugherty (2004) Depletion of natural killer cell function decreases atherosclerosis in LDL receptor -/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1049-1054. PDF file
  76. Henriques, T.A., S.S. D’souza, P.P. DeLuca, A. Daugherty, and L. A. Cassis. (2004) Orchiectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E deficient mice. Endocrinology. In press PDF file
  77. Boustany, C., K. Bharadwaj . A. Daugherty, D. Brown, D. Randall, and L.A. Cassis. (2004) Activation of the systemic and adipose renin angiotensin system in rats with diet-induced obesity and hypertension. American Journal of Physiology. 287: R943-949. PDF file
  78. Homeister, J.W., A. Daugherty, and J.B. Lowe. (2004) Deficiency of a(1,3)-fucosyltransferase VII limits atherosclerosis in apoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, In press. PDF file
  79. Whitman, S.C., P. Veeraraghavan, E. M. Kurowska, J. A. Manthey, A. Daugherty. Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. Atherosclerosis. 178: 25-32. PDF file
  80. Daugherty, A., D.L. Rateri, H. Lu, T. Inagami, and L.A. Cassis. (2004) Hypercholesterolemia augments circulating angiotensin peptides and contributes to formation of atherosclerosis through activation of AT1a. Circulation. 110: 3849-3857. PDF file
  81. Cassis L.A., M.J. Helton, D. Howatt, V.L. King, and A. Daugherty Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. British Journal of Pharmacology. 144: 443-448. PDF file
  82. Hennig B., G. Reiterer, M. Toborek, S.V. Mateev, A. Daugherty, E. Smart, and L.W. Robertson. (2005) Dietary fat interacts with PCBs to induce changes in lipid metabolism in LDL receptor deficient mice. Environmental Health Perspectives. 113: 83-87. PDF file
  83. Gavrila, D, W.G, Li, M.L. McCormick, M. Thomas, A. Daugherty, L. A. Cassis, F.J. Miller, Jr, L.W. Oberley, K.C. Dellsperger, and N.L. Weintraub. Vitamin E inhibits abdominal aortic aneurysms formation in angiotensin II-infused, apolipoproteinE-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 46: 1812-1822. PDF file
  84. Guo, Z., W. Su, S. Allen, H. Pang, A. Daugherty, E.J. Smart, and M.C. Gong. (2005) Cox-2 upregulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Cardiovascular Research. 67: 723-735. PDF file
  85. Reiterer, G., R. McDonald, E.J. Smart, A. Daugherty, M. Toborek, and B. Henning. (2005) Zinc deficiency increases plasma lipids and atherosclerosis markers in LDL-R deficient mice. Journal of Nutrition. 135: 2114-2118. PDF file
  86. Lutgens, E., S.P.M. Lutgents, B.C.G. Faber, S. Heeneman, M.M.J. Gijbels, M.P.J. de Winther, P. Frederiks, I. Van der Made, A. Daugherty, A.M., Sijbers, A. Fisher, C.J. Long, P. Saftig, D. Black, M.J. A.P. Daemen, and K.B.J.M. Cleutjens. (2005) Disruption of the cathespin K gene reduces atherosclerosis progression, induced plaque fibrosis, but accelerates macrophage foam cell formation. Circulation, 113: 98-107. PDF file
  87. Babamusta, F., D. L. Rateri, J.J. Moorleghen, D. A. Howatt, X.A. Li., and A. Daugherty (2006) Angiotensin II induced site specific intra-laminar hemorrhage in macrophage colony stimulating factor deficient mice. Atherosclerosis. 186: 282-290. PDF file
  88. Barisione, C, D.L. Howatt, J. Moorleghen, D.L. Rateri, and A. Daugherty. (2006) Rapid dilation of the abdominal aorta during infusion of angiotensin II detected noninvasively by high frequency ultrasound. Journal of Vascular Surgery. Journal of Vascular Surgery. 44:372-6.

  89. Mauldin, J.P., A. Mulya, A. Gebre, J.S. Parks, A. Daugherty, and C.C. Hedrick. (2006) Reduction in ABCG1 in type 2 diabetic mice increases macrophage foam cell formation. Journal of Biological Chemistry. 281: 21216-21224. PDF file

  90. Thomas, T., M.L. McCormick, D. Gavrila, F.J. Miller, A. Daugherty, L.A. Cassis, K.C., Dellsperger, and N.L. Weintraub. (2006) Deletion of p47phox attenuates angiotensin II-induced aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation. 114: 404-413. PDF file

  91. Cassis, L.A., D.L. Rateri, H. Lu, and A. Daugherty. (2007). Angiotensin II induction of atherosclerosis and abdominal aortic aneurysms requires expression of AT1a receptors on non-bone marrow derived cells. Arteriosclerosis Thrombosis and Vascular Biology. 27: 380-386.

  92. Lu, H., C. Boustany Kari, A. Daugherty, and L.A. Cassis. (2007). Angiotensin II increases adipose angiotensinogen expression. American Journal of Physiology - Endocrinology and Metabolism. 115: E1280-1287.  PDF file

  93. King, V.L., L.A. Cassis and A. Daugherty. (2007) Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in apoE-/- mice. American Journal of Pathology. 171: 2040-2047.  PDF file

  94. Shen, H., R. MacDonald, D. Bruemmer, A. Stromberg, A. Daugherty, X. Li, M. Toborek, and B. Hennig (2007) Zinc deficiency is detrimental to lipid metabolism in LDL-receptor-deficient mice treated with rosiglitazone. Journal of Nutrition. 137: 2339-2345.  PDF file

  95. Lu, H., D.L. Rateri, D.L. Feldman, E. R.J. Charnigo Jr, A. Fukamizu, J. Ishida, E.G. Oesterling, L. A. Cassis, and A. Daugherty. (2008) Renin Inhibition reduces hypercholesterolemia-induced atherosclerosis: the contribution of renin from bone marrow-derived cells. Journal of Clinical Investigation. 118: 984-993.  PDF file

  96. Henriques T, X. Zhang, F.B. Yiannikouris, A. Daugherty, and L.A. Cassis. (2008) Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. In press.  PDF file

  97. Daugherty, A., S.J. Szilvassy, I.F. Charo, D. Howatt, D.L. Rateri, and L.A. Cassis. Deficiency of CCR2 reduces angiotensin II-induced atherosclerosis and aneurysm formation in apolipoprotein E -/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology. In revision.

  98. King, V.L., A.Y. Lin, N. Ahluwalia, F. Kristo, D.A. Howatt, D. Shen, T.J.L. Anderson, A.M. Tagert, A.D. Luster, A. Daugherty, and R.E. Gerszten. Interferon-ã and the interferon-inducible chemokine, CXCL10, protect against aneurysm formation and rupture. Submitted to Circulation.  PDF file

  99. Police, S.B., A. Daugherty, and L.A. Cassis. Obesity promotes angiotensin II-induced abdominal aortic aneurysm formation. Circulation. In revision

  100. Mendez, J.I., D. Weiss, D. Gupta, A. Daugherty, K.K. Griendling, and W.R. Taylor. Smooth muscle-specific catalase over expression decreases atherosclerosis in apoE deficient mice. Submitted to Arteriosclerosis, Thrombosis, and Vascular Biology.

  101. Owens, A.P III, J.J. Moorleghen, C.A. McNamara, L.A. Cassis, and A. Daugherty. Angiotensin II induces ascending aortic hyperplasia through inhibitor of differentiation 3. Submitted to Circulation Research.

  102. Rateri, D.L., D.A. Howatt, X.Xie., L.A. Cassis, and A. Daugherty. Prolonged infusion of angiotensin ii promotes abdominal aortic aneurysm remodeling associated with adventitial macrophage recruitment. Submitted to Arteriosclerosis, Thrombosis, and Vascular Biology.

  103. Xie, X, J.J. Moorleghen, D.A. Howatt, D.L Rateri, L. A. Cassis, and A. Daugherty. Doxycycline fails to attenuate the progression of established abdominal aortic aneurysms. Submitted to Arteriosclerosis, Thrombosis, and Vascular Biology.

  104. Gairola, C.C., D.L. Howatt, and A. Daugherty. Dietary coenzyme Q10 supplementation fails to protect against cigarette smoke-mediated atherosclerosis in ApoE deficient mice. Submitted to Journal of Nutrition.

  105. Beckers, L., D. Lievens, E. Wijnands, U. Benbow, A. Daugherty. A. Newby, M.J.A.P. Daemen, and E. Lutgens. CD40L deficiency protects against aneurysm formation: a novel prevention strategy? Submitted

  106. Lu, H., D.L. Rateri, L.A. Cassis, and A. Daugherty (2008).  The role of the renin-angiotensin system in aortic aneurysmal diseases.  Current Hypertensin Reports. 10(2):99-106. PMID: 18474175  PDF file

back to topPublished Sequences

  1. Rateri, D.L., S. C. Whitman, and Daugherty, A. (1999) Sequence of cDNA for class A scavenger receptor from C57BL/6 mouse strain. GeneBank. Accession number AF203781

back to topBooks

  1. Daugherty, A., L.M. Cusumano and W. Jack. (1987). Therapeutic Advances in Hyperlipidemia and Atherosclerosis. Medstrategy Inc., St. Louis.
  2. Daugherty A., L.M. Cusumano and W. Jack (1989). Therapeutic Advances in Hyperlipidemia and Atherosclerosis. Update I. Medstrategy Inc., St. Louis.
  3. Daugherty A., P. Blank, and W. Jack (1990). Therapeutic Advances in Hyperlipidemia and Atherosclerosis. Update II. Medstrategy Inc., St. Louis.
  4. Daugherty, A. and J.W. Baynes - editors - (1991). Radical Therapies - Roles of antioxidants in disease treatment. Medstrategy Inc., St. Louis.
  5. Daugherty, A. (1992). Highlights of the XI International Symposium on Drugs Affecting Lipid Metabolism. Medstrategy Inc., St. Louis.
  6. Daugherty, A. and W. Jack. (1993). Atherosclerosis: Etiology and Therapeutic Strategies. Medstrategy Inc., St. Louis.

back to topInvited Chapters in Books

  1. Daugherty, A. (1990). Probucol reduces lipid deposition in vivo in atherosclerotic lesions of rabbits with hypercholesterolemia of either genetic or dietary origin. Xth International Symposium on Drugs Affecting Lipid Metabolism. Elsevier Scientific Publishers B.V. Amsterdam.
  2. Schonfeld, G, E.S. Krul, P. Talmud, A. Daugherty, and S.E. Humphries. (1990). Hypobetalipoproteinemia associated with truncated forms of apoB in a USA kindred. Xth International Symposium on Drugs Affecting Lipid Metabolism. Elsevier Scientific Publishers B.V. Amsterdam.
  3. Daugherty, A. and J.W. Heinecke. (1995). Epidemiology and risk factors in atherosclerosis. Pg 81-90. Vascular Surgery: Theory and Practice. Ed. A. Callow and A. Ernst. Appleton and Lange. Stamford, CT.  PDF file
  4. Heinecke, J.W. and A. Daugherty. (1995). Pathobiology of atherosclerosis lesions. Pg 91 - 104. Vascular Surgery: Theory and Practice. Ed. A. Callow and A. Ernst. Appleton and Lange. Stamford, CT.  PDF file
  5. Daugherty, A. and G. K. Hansson. Lymphocytes and Atherosclerosis. (2000). In Expression, Cell Interactions and Oxidation : New Foci in Atherosclerosis Research. Pg 230-249. Ed. R Dean and D. Kelly, Oxford University Press, Oxford, UK. PDF file
  6. Daugherty, A. and S.C. Whitman. Use of the mouse for studying atherosclerosis. (2003) The Transgenic Mouse: Methods and Protocols. Pg 293-309. Ed. M. Hofker. Humana Press. PDF file
  7. Daugherty, A. and D.L. Rateri (2006) Hyperlipidemia-induced atherosclerosis. A Handbook of Mouse Models for Cardiovascular Diseases. pg. 53-66. Ed Q. Xu, Wiley, London.
  8. Wang, Y.X.. Cassis, L.A. and Daugherty, A. (2006). Angiotensin II-induced abdominal aortic aneurysms. A Handbook of Mouse Models for Cardiovascular Diseases. pg 125-146. Ed Q. Xu, Wiley, London.  PDF file

  9. Daugherty, A. and D.L. Rateri (2006) Hyperlipidemia-induced atherosclerosis.  A Handbook of Mouse Models for Cardiovascular Diseases. pg. 53-66. Ed Q. Xu, Wiley, London.  PDF file

  10. Wang, Y.X.. Cassis, L.A. and Daugherty, A. (2006). Angiotensin II-induced abdominal aortic aneurysms.  A Handbook of Mouse Models for Cardiovascular Diseases. pg 125-146. Ed Q. Xu, Wiley, London.  PDF file

  11. Lu, H., D.L. Rateri, and A. Daugherty (2007) Immunostaining of mouse atherosclerotic lesions.  Vascular Biology Protocols. Eds. Sreejayan and J. Ren. Human Press, Totowa, New Jersey. In press. 

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back to topInvited Reviews

  1. Daugherty, A. and G. Schonfeld. (1985). Roles of lipoproteins in the initiation and development of atherosclerosis. Pharmacol Therap. 31: 337-355.  PDF file
  2. Daugherty, A. and D.L. Rateri. (1993) Pathogenesis of atherosclerotic lesions. Cardiol Rev. 1: 157-166.  PDF file
  3. Daugherty, A. (1993). Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 4: VI-20-VI-25.
  4. Daugherty, A. (1994). Lipoprotein receptors in atherosclerotic lesions. Relation to the pathology of atherosclerosis. Coron Art Dis. 5: 211-215.  PDF file
  5. Daugherty, A. (1994). Advances in Cell Biology of Atherosclerosis - Overview as Guest Editor. Coron Art Dis. 5: 185-188.  PDF file
  6. Daugherty, A. and S.E. Roselaar. (1995). Lipoprotein oxidation as a mediator of atherogenesis: Insights from pharmacological studies. Cardiovasc Res. 29: 297-311.  PDF file
  7. Daugherty, A. (1995). Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipidi. 6: U106-U112.
  8. Daugherty, A. (1997). Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 8: U11-U12.  PDF file
  9. Daugherty, A. (1997). Lymphocytes in atherosclerotic lesions - Bystanders of active participants. Atherosclerosis Alert. 2: 395-400.
  10. Daugherty, A. (1998) Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 9:179-180.  PDF file
  11. Daugherty, A. (1998) Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 9:613-615.
  12. Daugherty, A. (2000) Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 11:335-337.  PDF file
  13. Daugherty, A., S. C. Whitman, and D.L. Rateri (2000) Class A scavenger receptors. Curr Opin Cardiovasc Pulm Renal Invest Drugs. 2:223-232. PDF file
  14. Daugherty, A. (2001) Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 12:467-469.  PDF file
  15. Daugherty, A. (2002) Models of vascular disease in knockout mice. Am J Med Sci 323:3-10 PDF file
  16. Daugherty, A. and L.A. Cassis (2002) Mechanisms of arterial aneurysm formation. Curr Athero Reports. 4:222-227. PDF file
  17. Daugherty, A. and D.L. Rateri. (2002) T lymphocytes in atherosclerosis: The Yin-Yang of Th1 and Th2 influence on lesion formation. Circ Res. 90:1039-1040 PDF file
  18. Manning, M.W., L.A. Cassis, J. Huang, S.J. Szilvassy, and A. Daugherty (2002) Aortic aneurysms: Fresh insights from a novel animal model. Vasc Med. 7: 45-54. PDF file
  19. Daugherty, A. (2002). Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 13: 453-455. 
  20. Daugherty, A., and L.A. Cassis. (2004) Mouse models of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 24: 429-434. PDF file
  21. Daugherty, A. (2004) Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Curr Opin Lipid. 15: 93-95.
  22. Daugherty, A., and L.A. Cassis. (2004) Angiotensin II medicated development of vascular diseases. Trends in Cardiovasc Med. 14: 117-120. PDF file
  23. Daugherty, A., D.L. Rateri, and V.L. King. (2004) IL-5 links adaptive and natural immunity against atherosclerotic disease. J Clin Invest. 114: 317-320. PDF file
  24. Daugherty, A., and L.A. Cassis. Angiotensin II and aneurysms. Current Hypertension Reports. Curr Hypertension Reports 2004, 6:442-446. PDF file
  25. Daugherty, A. (2005) Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Current Opinions in Lipidology. 16: 257-259.  PDF file
  26. Greenland, P., A. Daugherty, D. Harrington, J. Bennett, H. Roberts, and K.A. Taubert. (2005) The use of nonsterodial anti-inflammatory drugs (NSAIDS). A science advisory from the American Heart Association. Circulation. 111: 1713-1716.  PDF file
  27. Daugherty, A., and D. L. Rateri. (2005) Development of experimental designs for atherosclerosis studies in mice. Methods. 36: 129-138. PDF file
  28. Daugherty, A., N.R. Webb, D. L. Rateri, and V. L. King (2005) Cytokine regulation of macrophage function in atherogenesis. J. Lipid Res. PDF file
  29. Daugherty, A. and D.L. Rateri. (2006) Atherosclerosis - Cell Biology and Lipoproteins - Commentary. Current Opinions in Lipidology. 17: 95-97.  PDF file

  30. Golledge, J., J. Muller, A. Daugherty, A. Van Rij, and P.E. Norman (2006).  Abdominal aortic aneurysms: Pathogenesis and implications for medical management. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2605-2613. (PMID 16973970)  PDF file

  31. Daugherty, A., D.L. Rateri, and L. A. Cassis. (2006) Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans. Annals of the New York Academy of Sciences. 1085: 82-91 (PMID 17182925)  PDF file

  32. Daugherty, A. and D.L. Rateri (2006) Atherosclerosis - Cell Biology and Lipoproteins - Commentary.  Current Opinions in Lipidology.
         17: 705-707. (PMID 17095917)  PDF file

  33. Antman, E.M., J.S. Bennett, A. Daugherty, C. Furberg, Harold Roberts, and K.A. Taubert. (2007)  American Heart Association Science Advisory on the use of nonsteroidal anti-inflammatory drugs (NSAIDS) - an update for clinicians. Circulation. 115: 1634-1642. (PMID 17325246)  PDF file

  34. Daugherty, A. and L.A. Cassis. (2007) Commentary on “Hackman et al, Angiotensin converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet 2006:368;659-665. Perspectives in Vascular Surgery and Endovascular Therapy. 19: 342-344. (PMID 17911572)  PDF file

  35. Lu, H, L.A. Cassis, and A. Daugherty. (2007) Arterial blood pressure and atherosclerosis in mice.  Current Drug Targets 8: 1181-1189. (PMID 18045096)  PDF file

  36. Lu, H., L.A. Cassis, and A. Daugherty (2008) Renin-angiotensin system in vascular aneurysms formation. Current Hypertension Reports. 10: 99-106. (PMID 18474175)

  37. Rader, D.J. and A. Daugherty (2008). Atherosclerosis. Translating new discoveries into novel therapies. Nature. 451: 904-913. (PMID 18288179)  PDF file

  38. Daugherty, A. and D.L. Rateri. (2008) Atherosclerosis - Cell Biology and Lipoproteins - Commentary.  Current Opinions in Lipidology. 19: 328-329. (PMID 18460928)

  39. Daugherty, A., D.L. Rateri, and H. Lu. (2008) As macrophages indulge, atherosclerotic lesions bulge (Editorial). Circulation Research. 102: 1445-1447. (PMID 18566308)  PDF file

     

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