< backZhenyu Li, M.D., Ph.D.

  • Assistant Professor

Selected Publications

  • Li Z, Zhang G, Feil R. Han J, Du X. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin aIIbb3. Blood. 2005. In press.
  • Li Z, Zhang G, Marjanovic JA, Ruan C, Du X. A platelet secretion pathway mediated by cGMP-dependent protein kinase. J Biol Chem. 2004 Oct 8; 279(41): 42469-75.
  • Du X, Marjanovic JA, Li Z. On the roles of cGMP and glycoprotein Ib in platelet activation. Blood. 2004 Jun 1; 103(11): 4371-2
  • Xi X, Bodnar RJ, Li Z, Lam SC, Du X. Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling. J Cell Biol. 2003 Jul 21; 162(2): 329-39.
  • Li Z, Zhang G, Le Breton GC, Gao X, Malik AB, Du X. Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem. 2003 Aug 15;278(33): 30725-31
  • Li Z, Ajdic J, Eigenthaler M, Du X. A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood. 2003 Jun 1; 101(11): 4423-9.
  • Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofmann F, Du X. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell. 2003 Jan 10; 112(1):77-86.
  • Bodnar RJ, Xi X, Li Z, Berndt MC, Du X. Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta). J Biol Chem. 2002 Dec 6; 277(49): 47080-7
  • Li Z, Xi X, Du X. A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3. J Biol Chem. 2001 Nov 9; 276(45): 42226-32.
  • Bodnar RJ, Gu M, Li Z, Englund GD, Du X. The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609. J Biol Chem. 1999 Nov 19; 274(47): 33474-9.
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