<< backOutstanding Contributions to Cardiovascular Research - 2001

Stanley L. Hazen, M.D., Ph.D.

Stanley L. Hazen, M.D., Ph.D.


Staff, Lerner Research Foundation
Cleveland Clinic Foundation, Cleveland, Ohio

Professor, Biology & Chemistry
Cleveland State University, Cleveland, Ohio

Selected Honors and Awards

  • 1985: Summa Cum Laude, Washington University, St. Louis, MO
  • 1992: Spencer T. & Ann W. Olin Medical Scientist Award, Washington University, St. Louis, MO
  • 1995 - 1997: Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians Award
  • 1999: Junior Faculty Award, American Federation of Medical Research
  • 1999: Merck Young Investigators Conference on Atherosclerosis Award

Selected Publications

  • Hazen SL, Hsu, FF, Mueller DM, Crowley JR, Heinecke J. Human neutrophils employ chlorine gas as an oxidant during phagocytosis. J. Clin. Invest. 1996:98;1283-1289
  • Hazen SL, Heinecke JW. 3-Chlorotyrosine, a specific marker for myeloperoxidase-catalyzed halogenation, is present in human atherosclerotic aorta. J. Clin. Invest. 1997:99;2075-2081.
  • Hazen SL, Gaut JP, Hsu FF, Crowley JR, d’Avignon A, Heinecke JW. p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-Cl- system of phagocytes, covalently modifies Ne-lysine residues of proteins. J. Biol. Chem. 1997:272;16990-16998.
  • Hazen SL, d’Avignon A, Hsu FF, Heinecke JW. Human neutrophils employ the myeloperoxidase-H2O2-Cl-system to oxidize a-amino acids to a family of reactive aldehydes: mechanistic studies identifying labile intermediates along the reaction pathway. J. Biol. Chem. 1998:273;4997-5005.
  • Podrez EA, Schmidt D, Hoff HF, Hazen SL. Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro. J. Clin. Invest. 1999 103;1547-1560.
  • Wu W, Chen Y, Hazen SL. Eosinophil peroxidase catalyzes protein nitration: Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders. J. Biol. Chem. 1999:274;25933-44.
  • Hazen SL, Zhang R, Wu W, Podrez EA, Shen Z, MacPhearson J, Schmitt D, Mitra SN, Cohen P, Hoff HF, Abu-Soud HM. Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: Pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo. Circ. Res. 1999:85:950-958.
  • Podrez EA, Febbraio M, Sheibani N, Schmitt D, Silverstein R. Hajjar DP, Cohen PA, Frazier WA, Hoff HF, Hazen SL. The macrophage scavenger receptor CD36 is the major receptor for LDL recognition following modification by monocyte-generated reactive nitrogen species. J. Clin. Invest. 2000:105;1095-1108.
  • Abu-Soud HM, Hazen SL. Nitric oxide is a physiological substrate for mammalian peroxidases. J. Biol Chem. 2000:275;37524-37532.
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