<< backOutstanding Contributions to Cardiovascular Research - 2000

Christine Edry Seidman, M.D.

Christine Edry Seidman, M.D.

Professor of Medicine and Genetics
Investigator, Howard Hughes Medical Institute
Harvard Medical School


And

Jonathan G. Seidman, Ph.D.

Bugher Professor of Cardiovascular Genetics
Investigator, Howard Hughes Medical Institute
Harvard Medical School


Selected Honors and Awards

Christine E. Seidman M.D.
  • 1992 American Heart Association Established Investigatorship Award
  • 1992 Robert J. and Claire Pasarow Foundation Award in Cardiovascular Research
  • 1997 American Heart Association, Edgar Haber Cardiovascular Award
  • 1997 American Heart Association, Helen B. Taussig Memorial Lecture
  • 1999 National Academy of Arts and Sciences
  • 1999 Institutes of Medicine
  • 1999 American Heart Association, Basic Science Prize
Jonathan G. Seidman Ph.D.
  • 1992 Robert J and Claire Pasarow Foundation in Cardiovascular Research
  • 1999 American Academy of Arts and Sciences

Selected Publications

  • 1. Basson, CT, Huang, T, Lin, RC, Bachinsky, DR, Weremowicz, S, Vaglio, A, Bruzzone, R, Quadrelli, R, Lerone, M, Romeo, G, Silengo, M, Pereira, A, Krieger, J, Mesquita, SF, Kamisago, M, Morton, CC, Pierpont, ME, Muller, CW, Seidman, JG, Seidman, CE. Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. Proc Natl Acad Sci U S A 1999 96:2919-24.
  • 2. Fatkin, D, Christe, ME, Aristizabal, O, McConnell, BK, Srinivasan, S, Schoen, FJ, Seidman, CE, Turnbull, DH, Seidman, JG. Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene. J Clin Invest 1999 103:147-53.
  • 3. Robertson, NG, Lu, L, Heller, S, Merchant, SN, Eavey, RD, McKenna, M, Nadol, JB Jr, Miyamoto, RT, Linthicum, FH Jr, Lubianca Neto, JF, Hudspeth, AJ, Seidman, CE, Morton, CC, Seidman, JG. Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nat Genet 1998 20:299-303.
  • 4. Schott, JJ, Benson, DW, Basson, CT, Pease, W, Silberbach, GM, Moak, JP, Maron, BJ, Seidman, CE, Seidman, JG. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 1998 281:108-11.
  • 5. Niimura, H, Bachinski, LL, Sangwatanaroj, S, Watkins, H, Chudley, AE, McKenna, W, Kristinsson, A, Roberts, R, Sole, M, Maron, BJ, Seidman, JG, Seidman, CE. Mutations in the gene for cardiac myosin-binding protein C and late- onset familial hypertrophic cardiomyopathy. N Engl J Med 1998 338:1248-57.
  • 6. Bamshad, M, Lin, RC, Law, DJ, Watkins, WC, Krakowiak, PA, Moore, ME, Franceschini, P, Lala, R, Holmes, LB, Gebuhr, TC, Bruneau, BG, Schinzel, A, Seidman, JG, Seidman, CE, Jorde, LB. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet 1997 16:311-5.
  • 7. Basson, CT, Bachinsky, DR, Lin, RC, Levi, T, Elkins, JA, Soults, J, Grayzel, D, Kroumpouzou, E, Traill, TA, Leblanc-Straceski, J, Renault, B, Kucherlapati, R, Seidman, JG, Seidman, CE. Mutations in human TBX5. Nat Genet 1997 15:30-5.
  • 8. Vastardis, H, Karimbux, N, Guthua, SW, Seidman, JG, Seidman, CE. A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat Genet 1996 13:417-21.
  • 9. Geisterfer-Lowrance, AA, Christe, M, Conner, DA, Ingwall, JS, Schoen, FJ, Seidman, CE, Seidman, JG. A mouse model of familial hypertrophic cardiomyopathy. Science 1996 272:731-4.
  • 10. Watkins, H, Conner, D, Thierfelder, L, Jarcho, JA, MacRae, C, McKenna, WJ, Maron, BJ, Seidman, JG, Seidman, CE. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nat Genet 1995 11:434-7.
  • 11. Ho, C, Conner, DA, Pollak, MR, Ladd, DJ, Kifor, O, Warren, HB, Brown, EM, Seidman, JG, Seidman, CE. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 1995 11:389-94.
  • 12. Pollak, MR, Brown, EM, Estep, HL, McLaine, PN, Kifor, O, Park, J, Hebert, SC, Seidman, CE, Seidman, JG. Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation. Nat Genet 1994 8:303-7.
  • 13. Thierfelder, L, Watkins, H, MacRae, C, Lamas, R, McKenna, W, Vosberg, HP, Seidman, JG, Seidman, CE. Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell 1994 77:701-12.
  • 14. Basson, CT, Cowley, GS, Solomon, SD, Weissman, B, Poznanski, AK, Traill, TA, Seidman, JG, Seidman, CE. The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome). N Engl J Med 1994 330:885-91.
  • 15. Shovlin, CL, Hughes, JM, Tuddenham, EG, Temperley, I, Perembelon, YF, Scott, J, Seidman, CE, Seidman, JG. A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3. Nat Genet 1994 6:205-9.
  • 16. Pollak, MR, Chou, YH, Cerda, JJ, Steinmann, B, La Du, BN, Seidman, JG, Seidman, CE. Homozygosity mapping of the gene for alkaptonuria to chromosome 3q2. Nat Genet 1993 5:201-4.
  • 17. Watkins, H, MacRae, C, Thierfelder, L, Chou, YH, Frenneaux, M, McKenna, W, Seidman, JG, Seidman, CE. A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3. Nat Genet 1993 3:333-7.
  • 18. Chou, YH, Brown, EM, Levi, T, Crowe, G, Atkinson, AB, Arnqvist, HJ, Toss, G, Fuleihan, GE, Seidman, JG, Seidman, CE. The gene responsible for familial hypocalciuric hypercalcemia maps to chromosome 3q in four unrelated families. Nat Genet 1992 1:295-300.
  • 19. Watkins, H, Rosenzweig, A, Hwang, DS, Levi, T, McKenna, W, Seidman, CE, Seidman, JG. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. N Engl J Med 1992 326:1108-14.
  • 20. Rosenzweig, A, Watkins, H, Hwang, DS, Miri, M, McKenna, W, Traill, TA, Seidman, JG, Seidman, CE. Preclinical diagnosis of familial hypertrophic cardiomyopathy by genetic analysis of blood lymphocytes. N Engl J Med 1991 325:1753-60.
  • 21. Tanigawa, G, Jarcho, JA, Kass, S, Solomon, SD, Vosberg, HP, Seidman, JG, Seidman, CE. A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. Cell 1990 62:991-8.
  • 22. Geisterfer-Lowrance, AA, Kass, S, Tanigawa, G, Vosberg, HP, McKenna, W, Seidman, CE, Seidman, JG. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell 1990 62:999-1006.
  • 23. Jarcho, JA, McKenna, W, Pare, JA, Solomon, SD, Holcombe, RF, Dickie, S, Levi, T, Donis-Keller, H, Seidman, JG, Seidman, CE. Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1. N Engl J Med 1989 321:1372-8.
  • 24. Seidman, CE, Wong, DW, Jarcho, JA, Bloch, KD, Seidman, JG. Cis-acting sequences that modulate atrial natriuretic factor gene expression. Proc Natl Acad Sci U S A 1988 85:4104-8.
  • 25. Bloch, KD, Scott, JA, Zisfein, JB, Fallon, JT, Margolies, MN, Seidman, CE, Matsueda, GR, Homcy, CJ, Graham, RM, Seidman, JG. Biosynthesis and secretion of proatrial natriuretic factor by cultured rat cardiocytes. Science 1985 230:1168-71.
  • 26. Seidman, CE, Bloch, KD, Klein, KA, Smith, JA, Seidman, JG. Nucleotide sequences of the human and mouse atrial natriuretic factor genes. Science 1984 226:1206-9.
  • 27. Seidman, CE, Duby, AD, Choi, E, Graham, RM, Haber, E, Homcy, C, Smith, JA, Seidman, JG. The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science 1984 225:324-6.
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