<< backOutstanding Contributions to Cardiovascular Research - 1999

Eric N. Olson, Ph.D.

Eric N. Olson, Ph.D.

Current Positions

Professor and Chairman
Department of Molecular Biology
U. T. Southwestern Medical Center

Hamon Center for Basic Cancer Research
U. T. Southwestern Medical Center

Selected Honors and Awards

  • American Heart Association Established Investigator Award
  • Burroughs Welcome Visiting Professorship in Basic Medical Sciences
  • Elected to American Academy of Arts and Sciences
  • 1992-1996 Member, Louis N. Katz Prize Selection Committee, American Heart Association
  • 1992-1997 Executive Committee, American Heart Association
  • 1995-1999 Member, Molecular Cytology Study Section, National Institutes of Health
  • 1998 Co-organizer, Keystone Symposium on Molecular Biology of the Cardiovascular System
  • 1998 Edgar Haber Cardiovascular Medicine Research Award, American Heart Association
  • 1999 Basic Research Award, American Heart Association

Selected Publications

  • Olson EN, Caldwell KC, Gordon JI, Glaser L. Regulation of creatine phosphokinase expression during differentiation of BC3Hl cells. J. Biol. Chem. 1983;258:2644-2652.
  • Olson EN, Glaser L, Merlie JP, Lindstrom J. Expression of acetylcholine receptor a-subunit mRNA during differentiation of the BC3Hl muscle cell line. J. Biol. Chem. 1984;259:3330-3336.
  • Olson EN, Towler DA, Glaser L. Specificity of fatty acid acylation of cellular proteins. J. Biol. Chem. 1985;260:3784-3790.
  • Wilcox CA, Hu JS, Olson EN. Acylation of proteins with myristic acid occurs cotranslationally. Science 1987;238:1275-1278.
  • Hu JS, Olson EN. Regulation of differentiation of the BC3H1 muscle cell line through cAMP- dependent and -independent pathways. J. Biol. Chem. 1988;263:19670-19677
  • Chakraborty T, Brennan T, Olson EN. Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding. J. Biol. Chem. 1991;266:2878-2882.
  • Brennan TJ, Edmondson DG, Li L, Olson EN. Transforming growth factor represses the actions of myogenin through a mechanism independent of DNA binding. Proc. Natl. Acad. Sci. USA 1991;88:3822-3826.
  • Brennan TJ, Chakraborty T, Olson EN. Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis. Proc. Natl. Acad. Sci. USA 1991;88:5675-5679.
  • Edmondson DG, Brennan TJ, Olson EN. Mitogenic repression of myogenin autoregulation. J. Biol. Chem. 1991;266,21343-21346.
  • Chakraborty T, Martin JF, Olson EN. Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system. J. Biol. Chem. 1992;267:17498-17501.
  • Olson EN. Regulation of muscle transcription by the MyoD family: The heart of the matter. Circ. Res. 1992;72:1-6.
  • Edmondson DG, Olson EN. Helix-loop-helix proteins as regulators of muscle-specific transcription. J. Biol. Chem. 1993;268:755-758.
  • Martin JF, Schwarz JJ, Olson EN. Myocyte enhancer factor (MEF) 2C: A tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. USA 1993;90:5282-5286.
  • Staudinger J, Perry M, Elledge SJ, Olson EN. Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system. J. Biol. Chem. 1993;268:4608-4611.
  • Cheng TC, Wallace M, Merlie JP, Olson EN. Separable regulatory elements govern myogenin transcription in embryonic somites and limb buds. Science 1993;261:215-218.
  • Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature 1993;364:501-506.
  • Merlie JP, Mudd J, Cheng TC, Olson EN. Myogenin and acetylcholine gene promoters mediate transcriptional regulation in response to motor enervation. J. Biol. Chem. 1994;269:1-7.
  • Lilly B, Galewsky S, Firulli AB, Schulz RA, Olson EN. D-MEF2: A MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis. Proc. Natl. Acad. Sci. USA 1994;91:5662-5666.
  • Olson EN, Rosenthal N. Homeobox genes and muscle patterning. Cell 1994;79:9-12.
  • Miano JM, Cserjesi P, Ligon KL, Periasamy M, Olson EN. Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis. Circ. Res. 1994;75:803-812.
  • Cheng TC, Tseng BS, Merlie JP, Klein WH, Olson EN. Activation of the myogenin promoter during mouse embryogenesis in the absence of positive autoregulation. Proc. Natl. Acad. Sci. USA 1995;92:561-565.
  • Lilly B, Zhao B, Ranganayakulu G, Paterson BM, Schulz RA, Olson EN. Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 1995;267:688-693
  • Black BL, Martin JF, Olson EN. The mouse MRF4 promoter is trans-activated directly and indirectly by muscle-specific transcription factors. J. Biol. Chem. 1995;270:2889-2892.
  • Srivastava D, Cserjesi P, Olson EN. New subclass of bHLH proteins required for cardiac morphogenesis. Science 1995;270:1995-1999.
  • Molkentin JD, Black BL, Martin JF, Olson EN. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 1995;83:1125-1136.
  • Li L, Miano JM, Mercer B, Olson EN. Expression of the SM22 promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J. Cell Biol. 1996;132:1-11
  • Li L, Miano JM, Cserjesi P, Olson EN. SM22, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis. Circ. Res. 1996;78:188-195.
  • Miano JM, Olson EN. Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis. J. Biol. Chem. 1996;271:7095-7103.
  • Miano JM, Topouzis S, Majesky MW, Olson EN. Retinoid receptor expression and all-trans- retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation 1996;93:1886-1895.
  • Molkentin JD, Black BL, Martin JF, Olson EN. Mutational analysis of the DNA binding, dimerization, and transcriptional activation of MEF2C. Mol. Cell. Biol. 1996;16:2627-2636.
  • Olson EN, Srivastava D. Molecular pathways controlling heart development. Science 1996;272:671-676
  • Molkentin J, Li L, Olson EN. Phosphorylation of the MADS-box transcription factor MEF2C enhances its DNA binding activity. J. Biol. Chem. 1996;271:17199-17204
  • Molkentin J, Olson EN. Combinatorial control of muscle development by bHLH and MADS-box transcription factors. Proc. Natl. Acad. Sci. USA 1996;93:9366-9373.
  • Srivastava D, Olson EN. Neurotrophin-3 knocks heart off Trk. Nature Med. 1996;2:1069-1071
  • Black BL, Ligon KL, Zhang Y, Olson EN. Cooperative transcriptional activation by the neurogenic bHLH protein MASH1 and members of the MEF2 family. J. Biol. Chem. 1996;271:26659-26663.
  • Burgess R, Rawls A, Brown D, Bradley A, Olson EN. Requirement of the paraxis gene for somite epithelialization and musculoskeletal patterning. Nature 1996;384:570-574.
  • Rawls AJ, Olson EN. MyoD meets its maker. Cell 1997;89:5-8.
  • Olson EN. Things are developing in cardiology. Circ. Res. 1997;80:604-606.
  • Srivastava D, Thomas T, Lin Q, Olson EN. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature Genetics 1997;16:154-160.
  • Lin Q, Schwarz J, Buchana C, Olson EN. Control of cardiac morphogenesis and myogenesis by the myogenic transcription factor MEF2C. Science 1997;276:1404-1407.
  • Fishman MC, Olson EN. Parsing the Heart: Genetic modules for organ assembly. Cell 1997;91:153-156.
  • Srivastava D, Olson EN. Knowing in your heart what's right. Trends in Cell Biol. 1997;7:447-453.
  • Molkentin JD, Olson EN. GATA4: A novel transcriptional regulator of cardiac hypertrophy? Circulation Res. 1997;96:3833-3835.
  • Firulli AB, McFadden DG, Srivastava D, Lin L, Olson EN. Heart and extraembryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nature Gen. 1998;18:266-270.
  • Molkentin JD, Lu J, Antos CL, Markham B, Richardson J, Robbins J, Grant S, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998;93:215-228.
  • Sussman MA, Lim HW, Cambon N, Taigen T, Olson EN, Robbins J, Colbert MC, Wieczorek DF, Molkentin JD. Prevention of cardiac hypertrophy by calcineurin inhibition. Science 1998;281:1690-1693.
  • Kowal RC, Richardson JA, Miano J, Olson EN. EVEC: A novel epidermal growth factor-like repeat-containing protein expressed by embryonic and diseased adult vasculature. Circ. Res., 1999;84:1166-1176.
  • Lu J, McKinsey T, Xu H, Wang D, Richardson JA, Olson EN. FOG-2: a heart-and brain-enriched cofactor for GATA transcription factors. Mol. Cell Biol., 1999;19:4495-4502..
  • Schneider MD, Olson EN. Cardiac Development: Towards a Molecular Basis for Congenital Heart Disease. In Cardiovascular Medicine, in press.
  • Musaro A, McCullagh K, Naya F, Olson EN, Rosenthal N. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATC1. Nature, in press.
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Comments: Darin Cecil | Last Modified: 11/04/2010
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