<< backYoung Investigator Award in Atherosclerosis - 1998

Guillermo García-Cardeña, Ph.D.

Guillermo García-Cardeña, Ph.D.

Vascular Research Division
Harvard Medical School


Selected Publications

  • García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G. Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998:392, 821-824
  • Sierra-Honigmann R, Nath AK, Murakami C, García-Cardena G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Rivero JR. Biological action of leptin as an angiogenic factor. Science. 1998:281, 1683-1686.
  • Woodward, A., García-Cardeña, G. , Liong, M., Sessa, W.C., Languino, L. The synergistic activity of avb3 and PDGF receptor increases cell migration. J. Cell Science. 1998:11, 469-478.
  • García-Cardeña G, Martasek P, Masters BSS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. J. Biol. Chem. 1997:272, 25437-25440.
  • Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC. Nitric Oxide Production Contributes to the Angiogenic Properties of Vascular Endothelial Growth Factor in Human Endothelial Cells. J. Clin. Invest. 1997:100, 3131-3139.
  • Shah V, Haddad FG, García-Cardeña G, Frangos JA, Groszmann RJ, Sessa WC. Liver Sinusoidal Endothelial Cells are Responsible for Nitric Oxide Modulation of Hepatic Resistance. J. Clin. Invest. 1997:100, 2923-2930.
  • Caulin-Glaser T, García-Cardeña G, Sarrel P, Sessa WC, Bender JR. 17b-Estradiol Regulation of Human Endothelial Cell Basal Nitric Oxide Release by an Apparent Calcium/Calmodulin-Independent Mechanism. Circ. Res. 1997:81, 885-892.
  • Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial Infection Induces Nitric Oxide Synthase in Human Neutrophils J.Clin. Invest. 1997:99, 110-116.
  • García-Cardeña G. Molecular Regulation of Endothelial Nitric Oxide Synthase. (1997) Doctoral Thesis. Yale University
  • Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC. Nitric Oxide Synthase Inhibitors Attenuate Transforming Growth Factor-b1-Stimulated Capillary Organization In Vitro. Am. J. Pathol. 1997:1835-1844.
  • García-Cardeña G. Fan R, Stern DF, Liu J, Sessa WC. Endothelial Nitric Oxide Synthase is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1 J. Biol. Chem. 1996:271, 27237-27240.
  • García-Cardeña G, Oh P, Liu J, Schnitzer JE, Sessa WC. Targeting of Nitric Oxide Synthase to Endothelial Cell Caveolae via Palmitoylation: Implications for Nitric Oxide Signaling. Proc. Natl. Acad. Sci. USA 1996:93, 6448-6453.
  • Liu J, García-Cardeña G, Sessa WC. Palmitoylation of Endothelial Nitric Oxide Synthase is Necessary for Stimulated Release of Nitric Oxide: Implications for Caveolae Localization. Biochemistry 1996:35, 13277-13281.
  • Atucha NM, Shah V, García-Cardeña G, Sessa WC, Groszmann RJ. Role of Endothelium in the Abnormal response of Mesenteric Vessels in Rats with Portal Hypertension and Liver Cirrhosis. Gastroenterology 1996:111, 1627-1632.
  • Liu J, García-Cardeña G, Sessa WC. Biosynthesis and Palmitoylation of Endothelial Nitric Oxide Synthase: Mutagenesis of palmitoylation sites, Cysteines-15 and or -26, Argues against Depalmitoylation-Induced Translocation of the Enzyme. Biochemistry 1995:34, 12333-12340.
  • Sessa WC, García-Cardeña, G, Liu J, Keh A, Pollock JS, Bradley J, Thiru S, Braverman IM, Desai KM. The Golgi Asssociation of Endothelial Nitric Oxide Synthase is Necessary for the Efficient Synthesis of Nitric Oxide. J. Biol. Chem. 1995:270, 17641-17644.
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