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THE CENTER OF RESEARCH IN OBESITY & CARDIOVASCULAR DISEASE

Photo of A7r5 cells derived from rat aorta were grown to confluence on glass coverslips. Cells were immunostained for alpha-actin (green) and MLCK (red). Colocalization of these two proteins are depicted in yellow. Cells were stimulated with phorbol esters to promote podosome formation.

The Center of Research in Obesity and Cardiovascular Disease (COCVD) at the University of Kentucky is supported by a $10.5 million, five-year award from the National Center for Research Resources (NCRR) (NIH grant P20 RR021954). The NCRR is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.

COCVD was created to identify mechanisms linking the epidemic of obesity to the high incidence of cardiovascular diseases in the obese population. This research focus is used as a platform to develop promising junior investigators who serve as principal investigators on research projects that address timely and significant questions related to obesity and cardiovascular disease. COCVD has assembled a group of established extramurally funded scientists who provide mentoring for the investigators. This mentorship facilitates the development of the investigators’ research projects and enhances their success in competing for independent NIH-funded research.

As a multidisciplinary collaborative, COCVD encourages the development of research infrastructure and shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease. Additionally, COCVD facilitates symposia and seminars for its research participants, and awards pilot/feasibility grants to non-COCVD faculty members to initiate new research focused on obesity and cardiovascular disease.

All users of COBRE Core services and equipment, including the statistical analysis that Dr. Richard Charnigo provides, must cite NIH grant P20 RR021954.

Recent Publications of COCVD Core Faculty that acknowledge support from NIH grant P20 RR021954:

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