COCVD

COCVD CARDIOVASCULAR RESEARCH CORE

The Cardiovascular Core facilitates the COCVD projects by providing the necessary equipment and technical personnel to quantify the extent of atherosclerotic lesions and perform pathologic characterization of vascular lesions for chronic measurement of blood pressure and for measurement of platelet aggregation. This rigorous, reproducible, state-of-the-art assessment of measurement of each of these parameters in cardiovascular disease is critical to the various models under study.

The Cardiovascular Research Core makes use of the equipment, expertise and well established methods available in the mentors' laboratories. Current facilities include 4 Nikon Optiphot-2 microscopes equipped with brightfield, darkfield, fluorescence, and phase capabilities connected to a true color image analysis system and conventional photographic facilities; 3 Leica Jung CM 1850 cryostats; 7 Nikon SMZ-1B dissecting microscopes with photographic capabilities; 3 Diagnostic Instruments Spot and 4 DXM1200 Nikon digital cameras with multiple copies of ImagePro analysis software. In addition, we have 4 Visitech tail cuff systems for measurement of blood pressure. We also have DSI platforms and analytical processors to measure blood pressure by telemetry on 8 mice simultaneously, and have recently purchased 20 mouse telemetry implants. With his extensive expertise in cardiovascular measures, Dr. Alan Daugherty oversees the Cardiovascular Research Core.

CARDIOVASCULAR RESEARCH CORE DIRECTOR
Alan Daugherty, Ph.D.
College of Medicine Senior Associate Dean of Research
Director, Cardiovascular Research Center
Room 243 Biomedical/Biological Sciences Research Building
741 S. Limestone Street
University of Kentucky
Lexington, KY 40506-0027
Phone: 859-323-3512