Sanders-Brown Faculty

Thomas V. Getchell, Ph.D.

Professor

Departmental Affiliation(s):

Physiology and Sanders-Brown Center on Aging

Research Focus:

To elucidate the inter- and intracellular signaling mechanisms associated with the genomic regulation of macrophage recruitment leading to progenitor cell proliferation, neurogenesis, and regeneration in the olfactory sensory epithelium. A second focus is to explain the molecular basis of aging in the olfactory sensory system using the senescence-accelerated mouse as a biogerontological resource leading to fundamental insights into the aging process when compared with other murine models. Genomic and proteomic techniques are being used to identify genes and proteins whose differential regulation is associated with chronological aging.

Recent Publications:

Borders AS, Getchell ML, Etscheidt JT, van Rooijen N, Cohen DA, Getchell TV. Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis. J Comp Neurol 501: 206-218, 2007.

Borders AS, Hersh MA, Getchell ML, van Rooijen N, Cohen DA, Stromberg AJ, Getchell TV. Macrophage-mediated neuroprotection and neurogenesis in the olfactory epithelium. Physiol Genomics 31: 531-543, 2007.

Chelvarajan L, Popa D, Liu Y, Getchell TV, Stromberg AJ, Bondada S. Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages. J Leukoc Biol 82: 403-416, 2007.

Vaishnav RA, Getchell ML, Huang L, Hersh MA, Stromberg AJ, Getchell TV. Cellular and molecular characterization of oxidative stress in olfactory epithelium of Harlequin mutant mouse. J Neurosci Res 86: 165-182, 2007.

Vaishnav RA, Getchell ML, Poon HF, Barnett KR, Hunter SA, Pierce WM, Klein JB, Butterfield DA, Getchell TV. Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization. J Neurosci Res 85: 373-385, 2007.