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CONTACT INFORMATION

332 Health Sciences Research Building
800 Rose Street
Lexington, KY 40536-0305

E-MAIL: gtell2@@uky.edu
PHONE: (859) 323-8564

Photo of Glenn C. Telling

Glenn C. Telling, M.A., Ph.D

 Professor

Departmental Affiliation(s):

Microbiology, Immunology & Molecular Genetics and Neurology, Sanders Brown Center on Aging, University of Kentucky Medical Center

 

Photo of Dr. Telling and his lab crew

Research Focus:

Deciphering the molecular mechanisms of prion replication, prion species barriers, and prion strains using a combination of molecular biological, biochemical, transgenic and cell biological approaches. A significant portion of his research effort is geared toward characterizing transgenic mouse models for studying chronic wasting disease, a prion disease of deer and elk in the US. In addition, his laboratory is investigating the mechanism by which mutations in the human PrP coding sequence that cause inherited human prion diseases result in the spontaneous production of infectious prions using transgenic and cell culture approaches. Other current projects in the lab include cell culture and transgenic investigations of PrP tagged with green fluorescent protein (GFP) to study PrP biosynthesis and trafficking in prion infected and uninfected cells and for detecting conformational changes in PrP during prion propagation and investigations of the role of proteolytic processing of PrP in prion replication.


Recent Publications:

Green, Kristi. M., Joaquín. Castilla, Tanya S. Seward, Dana L. Napier, Jean E. Jewell, Claudio Soto, Glenn C. Telling. Accelerated High Fidelity Prion Amplification Within and Across Prion Species Barriers.  PLoS Pathogens, 4(8):e1000139, 2008. Featured Article in PLoS Pathogens

Telling, Glenn C. Prion Protocols - Transgenic Mouse Models of Prion Diseases. Methods Mol. Biol., 459:249 -263, 2008

Green, Kristi M., Shawn R. Browning, Tanya S. Seward, Jean E. Jewell, Dana L. Ross, Michael A. Green, Elizabeth S. Williams, Edward A. Hoover and Glenn C. Telling. The Elk PRNP Codon 132 Polymorphism Controls Cervid and Scrapie Prion Propagation.  J. Gen. Virol., 89: 598-608, 2008 PDF

Kurt, Timothy D., Matthew R. Perrott, Carol J. Wilusz, Jeffrey Wilusz, Surachai Supattapone, Glenn C. Telling, Mark D. Zabel and Edward A. Hoover. Efficient In Vitro Amplification of Chronic Wasting Disease PrPres. J. Virol. 81(17): 9605-8, 2007 PDF

Nazor, Karah E., Tanya Seward and Glenn C. Telling.  Novel behavioral motor and neuropathological deficits in mice deficient for prion protein. Biochimica et Biophysica Acta, 1772(6): 645-653, 2007 PDF

Candace K. Mathiason, Jenny G. Powers, Sallie J. Dahmes, David A. Osborn, Karl V. Miller, Robert J. Warren, Gary L. Mason, Sheila A. Hays, Jeanette Hayes-Klug, Davis M. Seelig, Margaret A. Wild, Lisa L. Wolfe, Terry R. Spraker, Michael W. Miller, Christina J. Sigurdson, Glenn C. Telling, and Edward A. Hoover.  Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease. Science, 314: 133-6, 2006. PDF

Angers, Rachel C., Shawn R. Browning, Tanya S. Seward, Christina J. Sigurdson, Michael W. Miller, Edward A. Hoover and Glenn C. Telling. Prions in Skeletal Muscles of Deer with Chronic Wasting Disease. Science. Featured article in Science Express [Epub ahead of print on Jan 26, 2006] [Abstract] [Reprint]

Bian, Jifeng, Karah E. Nazor, Rachel Angers, Michael Jernigan, Tanya Seward, Adrian Centers, Michael Green and Glenn C. Telling. GFP-tagged PrP supports compromised prion replication in transgenic mice. Biochem. Biophys. Res. Comm, 340, 894–900, 2006 [Epub ahead of print on Dec 28, 2005]. PDF

Nazor, Karah E., Franziska Kuhn, Tanya Seward, Mike Green, Daniel Zwald, Mario Pürro, Jaqueline Schmid, Karin Biffiger, Aisling M. Power, Bruno Oesch, Alex J. Raeber and Glenn C. Telling. Immunodetection of disease-associated mutant PrP which accelerates disease in GSS transgenic mice. EMBO Journal, 24(13): 2472-2480, 2005. PDF

Telling, Glenn C. Anchors away: Of plaques and pathology in prion disease. N. Engl. J Med.,353(11), 1177-1179, 2005. PDF

Browning, Shawn R., Gary L. Mason, Tanya Seward, Mike Green, Gwyneth A. J.Eliason, Candace Mathiason, Christina Sigurdson, Michael W. Miller, Elizabeth S. Williams, Ed Hoover and Glenn C. Telling. Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP. J. Virol. 78(23): 13345-13350, 2004 PDF

Rajgopal Yadavalli, Rodney P. Guttmann, Tanya Seward, Adrian P. Centers, R. Anthony Williamson and Glenn C. Telling. Calpain-dependent endoproteolytic cleavage of PrP Sc modulates PrP Sc accumulation and prion propagation in scrapie infected cells. J. Biol. Chem., 279(21):21948-56, 2004 PDF