Sanders-Brown Faculty

Glenn C. Telling, Ph.D., M.A.

Associate Professor

Departmental Affiliation(s):

Microbiology, Immunology, and Molecular Genetics, Neurology and Sanders-Brown Center on Aging

Research Focus:

Deciphering the molecular mechanisms of prion replication, prion species barriers, and prion strains using a combination of molecular biological, biochemical, transgenic and cell biological approaches. A significant portion of his research effort is geared toward characterizing transgenic mouse models for studying chronic wasting disease, a prion disease of deer and elk in the US. In addition, his laboratory is investigating the mechanism by which mutations in the human PrP coding sequence that cause inherited human prion diseases result in the spontaneous production of infectious prions using transgenic and cell culture approaches. Other current projects in the lab include cell culture and transgenic investigations of PrP tagged with green fluorescent protein (GFP) to study PrP biosynthesis and trafficking in prion infected and uninfected cells and for detecting conformational changes in PrP during prion propagation and investigations of the role of proteolytic processing of PrP in prion replication.

Recent Publications:

Kurt TD, Perrott MR, Wilusz CJ, Wilusz J, Supattapone S, Telling GC, Zabel MD, Hoover EA. Efficient in vitro amplification of chronic wasting disease PrPRES. J Virol 81: 9605-9608, 2007.

Nazor KE, Seward T, Telling GC. Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expression. Biochim Biophys Acta 1772: 645-653, 2007.

Telling GC. Special issue: prion-related disorders. Biochim Biophys Acta 1772: 597, 2007.