Sanders-Brown Research

Charles D. Smith, M.D.

Professor

Faculty Title

Robert P. and Mildred Moore’s Professor in Alzheimer’s Research

Departmental Affiliation(s):

Neurology

Research Focus:

Applying structural and functional imaging techniques to the prediction, quantification and diagnosis of persons with Alzheimer's disease and related dementias.

In the Lab

Hima Chebrolu (Image Processing Scientist), Luann Hamon (Daughter’s Study Coordinator (859 323-3682) and ADNI Coordinator)

Barbara Martin (VCP Project Coordinator, Daughter's Co-coordinator, ADNI Co-coordinator)

Dorothy Ross (Daughter's Co-coordinator, ADNI Co-coordinator, Psychometrist: Daughter’s Study).

Kara Kennedy, MD (Neurosurgical Mapping Project)

Sebastian Espinosa, MD, MPH (Clinical Neuroimaging)

Recent Publications:

Martin SB, Covell DJ, Joseph JE, Chebrolu H, Smith CD, Kelly TH, Jiang Y, Gold BT. Human experience seeking correlates with hippocampus volume: convergent evidence from manual tracing and voxel-based morphometry. Neuropsychologia 45: 2874-2881, 2007.

Mehta SG, Watts GD, Adamson JL, Hutton M, Umberger G, Xiong S, Ramdeen S, Lovell MA, Kimonis VE, Smith CD. APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD). Genet Med 9: 9-13, 2007.

Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 66: 152-157, 2007.

Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young AB. Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal. J Neurosurg 106: 614-620, 2007.

Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR. Brain structural alterations before mild cognitive impairment. Neurology 68: 1268-1273, 2007.

Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR. Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly. Neurobiol Aging 28: 1075-1087, 2007.

Smith CD, Walton A, Slevin JT, Gerhardt GA, Umberger G, Smoot K, Schulze E, Gash D. Validation studies of the human movement analysis panel for hand/arm performance. J Neurosci Methods 165: 287-296, 2007.