Sanders-Brown Faculty

L. Creed Pettigrew, M.D., M.P.H

Professor, Director, Stoke Program

Departmental Affiliation(s):

Department of Neurology and Sanders-Brown Center on Aging

Research Focus:

Vascular disease affecting the nervous system in aging adults. As a clinician performing human-oriented research in stroke, he studies acute stroke therapy (neuroprotective drugs and novel thrombolytic agents), alternative approaches to prevention and vascular dementia (vitamin therapy, drugs designed to overcome insulin resistance), and treatment of cerebral amyloid angiopathy causing brain hemorrhage (homotaurine). His laboratory in the Sanders-Brown Center on Aging is funded by the NIH to study the role of tumor necrosis factor-alpha in an animal model of cerebral ischemic injury.

Recent Publications:

Blonder LX, Langer SL, Pettigrew LC, Garrity TF. The effects of stroke disability on spousal caregivers. NeuroRehabilitation 22: 85-92, 2007.

Korde AS, Pettigrew LC, Craddock SD, Pocernich CB, Waldmeier PC, Maragos WF. Protective effects of NIM811 in transient focal cerebral ischemia suggest involvement of the mitochondrial permeability transition. J Neurotrauma 24: 895-908, 2007.

Pettigrew LC, Bang H, Chambless LE, Howard VJ, Toole JF. Assessment of pre- and post-methionine load homocysteine for prediction of recurrent stroke and coronary artery disease in the Vitamin Intervention for Stroke Prevention Trial. Atherosclerosis 2007.

Ishibashi H, Pettigrew LC, Funakoshi Y, Hiramatsu M. Pharmacokinetics of arundic acid, an astrocyte modulating agent, in acute ischemic stroke. J Clin Pharmacol 47: 445-452, 2007.