Sanders-Brown Center On Aging

Sanders-Brown Faculty

 

CONTACT INFORMATION

Room 131, Sanders-Brown Center On Aging
800 South Limestone Street
Lexington, KY 40536-0230

E-MAIL: cnorr2@uky.edu
PHONE: (859) 257-1412 x490
CELL: (859) 227-2291
FAX: (859) 323-2866

Dr. Christopher M. Norris

Christopher M. Norris, Ph.D.

Assistant Professor

Departmental Affiliation(s):

Molecular and Biomedical Pharmacology

Research Focus:

Calcium signaling pathways in brain aging and aging-related diseases

In the lab:

Hafiz Mohammad Abdul (Scientist 2)

Irina Artiushin (Research Analyst)

Dusan Jeftinjia (Graduate Student).

Diana Mathis (Graduate Student)

Michelle Sama (Graduate Student)

Photo of Dr. Norris and his lab crew

Research Interests:

Dr. Norris' work focuses on the role of Ca2+ signaling mechanisms in brain aging and neurodegenerative disease, with recent emphasis on the Ca2+/calmodulin dependent protein phosphatase, calcineurin, and its downstream targets. Most studies are conducted on the hippocampus, or hippocampal cultures using a variety of experimental approaches including: adenoviral-mediated gene delivery, electrophysiology (patch clamp and sharp electrode recordings), immunocytochemistry, and protein biochemistry. Behavioral assessment in rodents also is used to test brain-behavior relationships.


Recent Publications:

Jeftinija DM, Wang QB, Hebert SL, Norris CM,Yan Z, Rich MM, Kraner SD. The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle. Muscle Nerve 36: 482-490, 2007.