Sanders-Brown Faculty

Harry LeVine, III, Ph.D.

Associate Professor

Departmental Affiliation(s):

Molecular and Cellular Biochemistry

Research Focus:

Neurodegeneration, Alzheimer’s disease

In the lab:

Melanie A. Silver (Grad Student)

Adam M. Weidner (Grad Student)

Lab Mission:

We seek to elucidate the contribution of misfolded proteins to chronic neurodegenerative diseases and to contribute to the development of therapeutic agents capable of modifying the course of these diseases. Our focus is on the Alzheimer’s ß-peptide (Aß) and its role in the cognitive decline in Alzheimer’s disease.

Recent Publications:

LeVine H, III. Small molecule inhibitors of Abeta assembly. Amyloid 14: 185-197, 2007.

Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H, III, Keller JN. Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiol Dis 27: 301-311, 2007.

LeVine, III, H. and Augelli-Szafran, C.E. “Chapter 4.5. Aß Polymerization Reduction” (Review) in Protein Folding Diseases: Enzyme Inhibitors & Other Agents as Prospective Therapies, H. John Smith, Claire Simons and Robert D.E. Sewell (eds), pp. 209-231, CRC Press, Boca Raton, FL, 2008.