Sanders-Brown Faculty
CONTACT INFORMATION
Room 209, Sanders-Brown Center On Aging
800 South Limestone Street
University of Kentucky
Lexington, KY 40536-0230
E-MAIL hlevine@email.uky.edu
PHONE: (859) 257-1412 x224
FAX: (859) 323-2866
Harry LeVine, III, Ph.D.
Associate Professor
Departmental Affiliation(s):
Molecular and Cellular Biochemistry
Research Focus:
Neurodegeneration, Alzheimer’s disease
In the lab:
Melanie A. Silver (Grad Student)
Adam M. Weidner (Grad Student)
Lab Mission:
We seek to elucidate the contribution of misfolded proteins to chronic neurodegenerative diseases and to contribute to the development of therapeutic agents capable of modifying the course of these diseases. Our focus is on the Alzheimer’s ß-peptide (Aß) and its role in the cognitive decline in Alzheimer’s disease.
Recent Publications:
LeVine H, III. Small molecule inhibitors of Abeta assembly. Amyloid 14: 185-197, 2007.
Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H, III, Keller JN. Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiol Dis 27: 301-311, 2007.
LeVine, III, H. and Augelli-Szafran, C.E. “Chapter 4.5. Aß Polymerization Reduction” (Review) in Protein Folding Diseases: Enzyme Inhibitors & Other Agents as Prospective Therapies, H. John Smith, Claire Simons and Robert D.E. Sewell (eds), pp. 209-231, CRC Press, Boca Raton, FL, 2008.
