Sanders-Brown Faculty
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CONTACT INFORMATION
Room 209, Sanders-Brown Center On Aging
800 South Limestone Street
University of Kentucky
Lexington, KY 40536-0230
E-MAIL hlevine@email.uky.edu
PHONE: (859) 257-1412 x224
FAX: (859) 323-2866
Harry LeVine, III, Ph.D.
Associate Professor
Departmental Affiliation(s):
Molecular and Cellular Biochemistry
Research Focus:
Neurodegeneration, Alzheimer’s disease
In the lab:
Irfan Baig, Research Associate
Adam
M. Weidner, Grad Student 
Lab Mission:
We seek to elucidate the contribution of misfolded proteins to chronic neurodegenerative diseases and to contribute to the development of therapeutic agents capable of modifying the course of these diseases. Our focus is on the Alzheimer’s ß-peptide (Aß) and its role in the cognitive decline in Alzheimer’s disease.
Recent Publications:
Rosen, R. F., Walker, L. C., and
LeVine, III, H.
“PIB Binding in Aged Primate Brain: Unique Enrichment of High Affinity
Sites in Humans with AD", Neurobiology of Aging
doi:10.1016/j.neurobiolaging.2009.02.011.
Abdul, H. M., Sama, M. A., Furman, J. L., Patel, E. S., Beckett, T. L., Weidner, A. M., Murphy, M. P., LeVine III, H., Krainer, S. D., and Norris, C. M. “Cognitive decline in Alzheimer’s disease is associated with selective changes in calcineurin/NFAT signaling”, in press
Murphy, M. P. and LeVine, III, H.,
“Alzheimer’s Disease and the β-Amyloid Peptide”, J. Alzheimer’s Disease,
in press,
2009.
Rosen, R. F., Ciliax, B. J.,
Gearing, M., Dooyema, J., Wingo, T. S., Lah, J. J., Ghiso, J.,
LeVine, III, H., Walker, L.
C. “Deficient High-Affinity Binding of Pittsburgh Compound B in a Case of
Alzheimer's Disease”, Acta Neuropathologica,
in press
Simons, L. J., Augelli-Szafran, C. E., Caprathe, B. W., Callahan, M., Graham, J. M., Kimura, T., Lai, Y., LeVine, III, H., Lipinski, W., Sakkab, A. T., Tasaki, Y., Walker, L. C., Yasunaga, T., Ye, Y., Zhuang, N. “The Synthesis and Structure-Activity Relationship of Substituted N-Phenyl Anthranilic Acid Analogs as Amyloid Aggregation Inhibitors”, Bioorganic & Medicinal Chemistry Letters, 19: 654-657 (2009).
LeVine, III, H.
and Walker, L. C. “Molecular Polymorphism of Aβ in Alzheimer’s Disease
Plaques”, Neurobiology of Aging,
doi:10.1016/j.neurobiolaging.2008.05.026.
Walker, L. C., Rosen, R. F., and
LeVine, III, H.
“Diversity of Aβ Deposits in the Aged Brain: A Window
on Molecular Heterogeneity?” Romanian J. Morph. Embryol. 49(1): 5-11
(2008).
LeVine, III, H.
“Ligand Imaging of Misfolded Proteins”, in Protein Misfolding
Diseases: Current and Emerging Principles and Therapies, C. M. Dobson, J. W.
Kelly and M. Ramirez-Alvarado, (eds), John Wiley and Sons, in press,
2008.
LeVine, III, H. and Augelli-Szafran, C.E. “Chapter 4.5. Aß Polymerization Reduction” (Review) in Protein Folding Diseases: Enzyme Inhibitors & Other Agents as Prospective Therapies, H. John Smith, Claire Simons and Robert D.E. Sewell (eds), pp. 209-231, CRC Press, Boca Raton, FL, 2008.
Murphy, M. P., Beckett, T. L., Ding, Q., Markesbery. W. R., St. Clair, D. K., Flood, D. G., LeVine, III, H., and Keller, J. N. “Aβ solubility and deposition during AD progression and in APPxPS-1 knock-in mice". Neurobiology of Disease, 27(3): 301-311 (2007).
LeVine, III, H. “Small Molecule Inhibitors of Aβ Assembly”, Amyloid: The Journal of Protein Folding Disorders, 14(3):185-197 (2007).