Sanders-Brown Faculty

Richard J. Kryscio, Ph.D.

Professor

Departmental Affiliation(s):

Statistics and Chair, Biostatistics

Research Focus:

(1) longitudinal data analysis with a focus in subareas related to Markov transition models, shared random effects, and missing data; (2) prevention trials in Alzheimer’s disease; (3) design and analysis of clinical trials with emphasis on ALS, PD, and traumatic brain injury; (4) screening for early detection of ovarian cancer; and (5) estimating relative risk on the line using nearest neighbor statistics.

IN THE LAB

Chunxu “ Kate” Liu (M.S.)

LAB MISSION

To provide expert advice on study design and data analysis to all investigators in the Center on Aging and related programs in aging. To conduct research on statistical methodology relevant to Alzheimer’s disease, aging, the neurosciences, and ovarian cancer.

Recent Publications:

Andrykowski M, Zhang M, Pavlik E J, Kryscio R J Factors associated with return for routine annual screening in an ovarian cancer screening program Gyn Oncology, 104: 695-701, 2007. Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio RJ, Chebrolu H, Walton A, Wagner R, Young AB Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson’s disease: response to 1 year each of treatment and withdrawal. J Neurosurgery, 2007, 106(4): 614-620.

Bagley A.M., Gorton G., Oeffinger D., Barnes D., Calmes J., Nicholson d., Abel M., Kryscio R. , Rogers S., Tylkowski C. Outcome assessments I children with cerebral palsy, part II: discriminatory ability of outcome tools Dev. Med. Child Neurol., 2007, 49(3): 181-186.

Becker WJ, Kryscio RJ. Treatment of migraine: a headache for the emergency department. Neurology 69: 2034-2035, 2007.

Christodoulides N, Floriano P.N., Miller C.S., Ebersole J.L,, Mohanty S., Dharshan P., Griffin M., Lennart A., Ballrad K.I., King C.P. Jr., Langub M.C., Kryscio R.J. , Thomas M.V., McDevitt J.T. Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis. Ann N.Y. Acad Sci. 2007, 1098: 411-428.

DeSimone C.P., Van Ness J.S., Cooper A.L., Modesitt S.C., DePriest P.D., Ueland F.R., Pavlik E.J., Kryscio R.J. , van Nagell J.R. Jr. The treatment of lateral T1 and T squamous cell carcinoma of the vulva confined to the labium majus or minus Gynecol. Oncol. 2007, 104(2): 390-395.

Dietrich C.S. 3rd, DeSimone C.P., Modesitt S.C., Ueland F.R., Pavlik E.J., Kryscio R., Cibull M, Huh W., Partridge E., Nunman T.M., Schidler J., Higgins R.V., van Nagell J.R. 2nd Primary appendiceal cancer: gynecologic manifestations and treatment optionsGyencol. Oncol. 2007, 104(3): 602-606.

Griffith J.R., Clasey J.L., King J.T., Gantz S., Kryscio R.J. , Bada H.S. Role of parents in determining children’s physical activity. World J Pediatrics, 2007, 3(4): 265-270.

Modesitt S.C., Tian C., Kryscio R. , Thigpen J.T., Randall M.E., Gallion H.H., Fleming G.F. Impact of body mass index on treatment outcomes in endometrial cancer patients receiving doxorubicin and cisplatin: a Gynecology Oncology Group study. Gynecol. Oncol., 2007, 105(1): 59-65.

Oeffinger D., Gorton G., Bagley A., Nicholson D. Calmes J, Abel M., Damiano D, Kryscio R. , Rogers S., Tylkowski C. Outcome assessments in children with cerebral palsy, part I: descriptive characteristics of GMFCS Levels I to III. Dev. Med. Child Neurol 2007, 49(3): 172-180.

Salazar JC, Schmitt FA, Yu L, Mendiondo MM, Kryscio RJ. Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia. Stat Med 26: 568-580, 2007.

Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young AB. Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal. J Neurosurg 106: 614-620, 2007.

Stein P.S., Derosiers M., Donegan S.L., Yepes J.F., Kryscio R.J. Tooth loss, dementia and neuropathology in the NUN study J. Am. Dent. Assoc. 2007, 138(10): 1314-1322.

Tyas S L, Salazar J C, Snowdon D A , Desrosiers M F, Riley K P, Mendiondo, M S, Kryscio R J< Transitions to mild cognitive impairment, dementia and death: findings from the NUN study. Am. J. Epidemiology, 2007, 165(11): 1231-1238.

Van Nagell J.R. Jr., dePriest P.D. Ueland F.R., DeSimone C.P., Cooper A.L., McDonald J.M., Pavlik E.J., Kryscio R.J. Ovarian cancer screening with annual transvaginal sonography: findings of 25,000 women screened Cancer 2007, 109(9): 1887-1896.

Walker J.L., Kryscio R., Smith J., Pilla A., Sisken B.E. Electromagnetic field treatment of nerve crush injury in a rat model: effect of signal configuration on functional recovery. Bioelectromagnetics 2007, 28(4): 256-263.

Tarima S.S., Dmitriev, Y.G., Kryscio R.J. On weighted least squares in the presence of missing data. Model Assisted Statistics and Applications, 2(30: 125-136, 2007.

Kryscio, RJ, Schmitt, FA., Mendiondo, M.S., Markesbery, W.R. Hypertension as a risk factor for transitions from normal to dementia and mild cognitive impairment. Research and Practice in Alzheimer’s disease and Cognitive Disorders. To appear Vol 10, 2007.