Sensation seeking is a multi-dimensional construct that can be parceled into two separate constructs, namely, reward seeking and inhibition, both of which have been associated drug abuse. Both reward seeking and inhibition are traits that can be studied in both human and non-human species. Individual differences in reward seeking and inhibition are associated with differences in stimulant drug self-administration and neural function. Individual differences in reward seeking and inhibition are associated with initiation, escalation, and cessation of drug use across the lifespan, most notably during the transition from adolescence to young adulthood. An understanding of reward seeking and inhibition as risk factors and targeting variables will enhance the design of anti-drug televised public service announcements that will be effective in the field. Sensation seeking is a biologically based personality trait that alters risk for drug abuse.

Sensation seeking can be studied in both human and non-human species using experimental and non - experimental approaches.

A better understanding of sensation seeking and related individual differences will improve our prevention intervention efforts.

Ultimately, basic research on sensation seeking must be transferred from the laboratory to the field.