Research Initiatives

APEX AMI
Acute Myocardial Infarction study to determine whether pexelizumab treatment
reduces all-cause mortality.
PI: David Moliterno, MD
Study Coordinator: Kim Pennington, RN, CCRC
Status: Enrolling

COSTAR II
A study comparing the COSTAR Paclitaxel- Eluting Coronary Stent System and the TAXUS™ Express2™ Drug Eluting Coronary Stent System patients with single and multivessel coronary disease.
PI: Debabrata Mukherjee, MD
Study Coordinator: Jennifer McGregor, CRA
Status: Enrolling

EVENT REGISTRY
A comparison of Drug Eluting Stents to Bare Metal Stents on rates of complications.
PI: David Moliterno, MD
Study Coordinator: Patrice Boggs, CCRC
Status: Enrolling

CRUSADE
A Quality Improvement Initiative to improve the care of high-risk patients with Non ST Elevation Acute Coronary Syndrome by collecting data regarding practice patterns in the U.S. and using that data to target educational interventions designed to improve adherence to the revised ACC/AHA practice guidelines.
PI: Steve Steinhubl, MD
Study Coordinator: Kim Pennington, RN, CCRC
Status: Enrolling

ACCOMPLISH
A study to compare the effects of Lotrel (amlodipine/benazepril) to benazepril and hydrochlorothiazide combined on the reduction of cardiovascular morbidity and mortality in patients with high risk hypertension.
PI: Craig Chasen
Study Coordinator: Lydia Withrow, RN, CCRC
Status: Enrollment closed

ACUITY
A study to establish optimal anti-thrombotic treatment regimens in patients with Unstable Angina or Non ST Elevation Myocardial Infarction undergoing early invasive management.
PI: Steve Steinhubl, MD
Study Coordinator: Lydia Withrow, RN, CCRC
Status: Enrollment Closed

APPRAISE I
A study to evaluate the safety of 4 doses of apixaban compared to placebo over a 26 week treatment period in patients with Acute Coronary Syndrome.
PI: Steve Steinhubl, MD
Study Coordinator: Jennifer McGregror, CRA
Status: Enrollment to begin soon

CHAMPION PCI
A study to demonstrate that the efficacy of Cangrelor is superior, or at least non-inferior to that of clopidogrel in subjects requiring a percutaneous coronary intervention.
PI: Steve Steinhubl, MD
Study Coordinator: Kim Pennington, RN, CCRC
Status: Enrollment to begin soon

COMPASS II
A study to compare the treatment with bosentan and sildenafil vs sildenafil alone in symptomatic patients with Pulmonary Arterial Hypertension.
PI: David Booth
Study Coordinator: Lydia Withrow, RN, CCRC
Status: Enrollment to begin soon

CRESCENDO

A study to evaluate the effects of rimonabant taken daily for reducing the risk of Heart attacks and strokes in abdominally obese patients with clustering risk factors.
PI: Steve Steinhubl, MD
Study Coordinator: Patrice Boggs, CCRC
Status: Enrollment to begin soon

FREEDOM
A superiority trial with equal allocation, of patients with multivessel coronary disease being randomized on a 1:1 basis either to Coronary Artery Bypass Graft or multivessel stenting using drug-eluting stents. A registry of 2000 patients will also be recruited concurrently, comprised of eligible non-consenting patients for the randomized trial.
PI: Debabrata Mukherjee, MD
Study Coordinator: Kim Pennington, RN, CCRC
Status: Enrollment to begin soon

IMPROVE IT
A study to evaluate the clinical benefit of Ezetimebe/Simvastatin Combination compared with Simvastatin (Cholesterol lowering medications) alone in stabilized acute coronary syndrome patients.
PI: Steve Steinhubl, MD
Study coordinator: Patrice Boggs, CCRC
Status: Enrolling

LESS AF
A study to examine the effects of different atrial pacing sites.
PI: John Gurley, MD
Study Coordinator: Kim Pennington, RN, CCRC
Status: Enrollment closed

PERISCOPE
A study comparing the effect of treatment with Pioglitazone HCl versus Glimepiride on the percent change in coronary artery atheroma volume in subjects with type 2 diabetes using intravascular ultrasound (IVUS) imaging of the coronary arteries.
PI: Khaled Ziada, MD
Study Coordinator: Ruth Oremus, RN, CCRC
Status: Enrolling

PREMIUM
A study to evaluate the impact of percutaneous closure employing the AMPLATZER PFO Occluder on the incidence of migraine headaches.
PI: John Gurley, MD
Study Coordinator: Jennifer McGregor, CRA
Status: Enrollment to begin soon

PRINCE
A study to demonstrate the safety and efficacy of NIRTINOL™ Carotid Set in the treatment of patients with Carotid Artery disease.
PI: Debebrata Mukherjee, MD
Study coordinator: Ruth Oremus, RN, CCRC
Status: Enrollment to begin soon

PERIPHERAL VASCULAR DISEASE REGISTRY
A registry for development and validation of risk adjustment models for clinical outcomes, and appropriateness of percutaneous interventions in vascular patients.
PI: Debabrata Mukherjee, MD
Coordinator: Liliana Kuvlieva, MD
Status: Enrolling

SHINE
A study to evaluate a new blood thinner called hexadecasaccharide (SR123781A) in prevention of complications in patients with symptoms of acute coronary disease.
PI: Debabrata Mukherjee, MD
Study coordinator: Ruth Ormeus, RN, CCRC
Status: Enrolling

STRADIVARIUS
A study to evaluate rimonabant given daily for inhibition of atherosclerosis progression assessed Intra Vascular Ultrasound, in overweight patients with clustering risk factors.
PI: Khaled Ziada, MD
Study coordinator: Ruth Oremus, RN, CCRC
Status: Enrollment closed

STRIDE III
A long term open-label study evaluating the safety of Sitaxsentan Sodium treatment inpatients with Pulmonary Arterial Hypertension.
PI: David Booth, MD
Study Coordinator: Lydia Withrow, RN, CCRC
Status: Enrollment Closed

TRA PCI
A study to Evaluate the Safety of SCH 530348 in Subjects Undergoing Non-Urgent Percutaneous Coronary Intervention.
PI: Khaled Ziada, MD
Study coordinator: Jennifer McGregor, CRA
Status: Enrolling

TRIUMPH
A placebo-controlled study to assess the safety and efficacy of Nitric Oxide Synthase Inhibition with Tilarginine Acetate Injection in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction.
PI: Steve Steinhubl, MD
Study Coordinator: Lydia Withrow, RN, CCRC
Status: Enrolling

WATCHMAN
A study to demonstrate the safety of the WATCHMAN device in patients with
non-valvular atrial fibrillation (AF) who require treatment for potential thrombus
formation and are eligible for warfarin therapy.
PI: John Gurley, MD
Study Coordinator: Jennifer McGregor, CRA
Status: Enrolling

Comments to Internal Medicine's Tech Department, Last Modified: Friday, April 14, 2006
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