Biochemistry

Regulation of Ras G-protein signaling.

Elucidating the role of phosphorylation and ubiquitination in neurodegenerative disease

Relationship of protein misfolding to disease

Glucose regulation of transport, metabolism and gene expression in diabetes

Structure of damaged DNA and its role in carcinogenesis; function of post-translational modification in signal transduction

Mechanism of alternative splicing; Signal transduction pathways regulating alternative splicing; Alternative (mis)splicing and disease

Intracellular calcium homeostasis and signaling

Molecular mechanism of mammalian autophagy and its relevance to human diseases; neurodegeneration/cancer/aging; proteomics.

Development of new synthetic methods, the synthesis of natural products and the development of photoactive analogs of natural products for elucidating receptor binding; and the synthesis of various drugs and natural products for studying interesting biological problems in collaboration with colleagues.

Molecular mechanisms of exocytosis