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LeVine Lab

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SELECTED LAB PUBLICATIONS

LeVine, III, H. "Thioflavine T Interaction with Synthetic Alzheimer's Disease β - Amyloid Peptides: Detection of Amyloid Aggregation in Solution", Protein Science 2: 404-410 (1993).

 LeVine, III, H. "Soluble Multimeric Alzheimer β(1‑40) Pre - Amyloid Complexes in Dilute Solution.", Neurobiology of Aging 16: 755-764 (1995). 

 LeVine, III, H. "Thioflavine T Interaction with Amyloid β-Sheet Structures."  Amyloid: The International Journal of Experimental and Clinical Investigation 2: 1-6 (1995). 

 LeVine, III, H. "Stopped-flow Kinetics Reveal Multiple Phases of Thioflavine T Binding to Alzheimer β(1-40)", Arch. Biochem. Biophys. 342: 306-316 (1997). 

LeVine, III, H. "Quantification of β-Sheet Amyloid Fibril Structures with Thioflavin T." Meth. Enzymol. 309: 274-284 (1999). 

 LeVine, III, H. and Scholten, J. D. "Screening for Pharmacologic Inhibitors of Amyloid Fibril Formation." Meth. Enzymol. 309: 467-476 (1999). 

 LeVine, III, H. "¹²⁵I-Labeled ApoE Binds Competitively to β(1-40) Fibrils with Pathological Chaperone Proteins", Amyloid: The International Journal of Experimental and Clinical Investigation, 7: 83-89 (2000). 

 Walker, L. C. and LeVine, III, H. "The cerebral proteopathies"  Neurobiology of Aging 21: 559-561 (2000). 

Walker, L. C. and LeVine, III, H. “The Cerebral Proteopathies: Neurodegenerative Disorders of Protein Conformation and Assembly”, Molecular Neurobiology 21(1/2) 83-95 (2001). 

 Wegiel, J., Wang, K.-C., Imaki, H., Rubenstein, R., Wronska, A., Osuchowski, M., Lipinski, WJ., Walker, LC., LeVine, III, H. “The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APPsw mice”, Neurobiology of Aging 22: 49-61 (2001). 

 LeVine, III, H. “4, 4’-dianilino-1, 1’-binaphthyl-5, 5’-disulfonate (bis-ANS) Reports on Non- β-Sheet Conformers of Alzheimer’s Peptide β(1-40)”, Arch. Biochem. Biophys. 404: 106-115 (2002). 

LeVine, III, H. "The Challenge of Inhibiting Aβ Fibrillogenesis (Review) Current Medicinal Chemistry 9(11): 1121-1133 (2002). 

Walker, L.C., Bian, F., Callahan, M. J., Lipinski, W. J., Durham, R. A., and LeVine, III, H.. “Modeling Alzheimer’s Disease and Other Proteopathies In Vivo: Is Seeding the Key?” Amino Acids   23: 83-88 (2002). 

Walker, L. C. and LeVine, III, H. “Proteopathy: The Next Therapeutic Frontier?”, Current Opinion in  Investigational Drugs 3(5): 782-787 (2002).

LeVine, III, H. “Challenges of Targeting Ab Fibrillogenesis and Other Protein Folding Disorders” (editorial), Amyloid: The Journal of Protein Folding Disorders, 10: 133-135 (2003).

LeVine, III, H. “Y10W b(1-40) Fluorescence Reflects Epitope Exposure in Conformers of Alzheimer’s β-Peptide”, Arch. Biochem. Biophys. 417: 112-122 (2003).

Mazur-Kolecka, B., Frackowiak, J., LeVine, III, H., Haske,  T., Evans, L., Sukontasup, T.,  and Golobek, A. “TGFβ1 Enhances formation of cellular Aβ /ApoE deposits in vascular myocytes”, Neurobiology of Aging, 24: 355-364 (2003).

LeVine, III, H. “The Amyloid Hypothesis and the Clearance and Degradation of Alzheimer’s β-Peptide”, J. Alzheimer’s Disease, 6(3): 303-314 (2004).

LeVine, III, H. “Alzheimer’s β-Peptide Oligomer Formation at Physiologic Concentrations”, Analyt. Biochem. 325: 81-90 (2004).

LeVine, III, H. “Multiple Ligand Binding Sites on Aβ(1-40) Fibrils” – Amyloid: The International Journal of Experimental and Clinical Investigation, 12(1): 5-14 (2005).

Walker, L. C., Ibegbu, C. C., Todd, C. W., Robinson, H. L., Jucker, M., LeVine, III, H. and Gandy, S. “Emerging Prospects for the Disease-Modifying Treatment of Alzheimer's Disease”, (review), Biochemical Pharmacology, 69: 1001-1008 (2005).

LeVine, III, H. and Walker, L. C. “Chapter 11. Models of Alzheimer’s Disease”, (Review) in Handbook of Models for Human Aging, Conn, P. M. (ed), pp. 121-134, Academic Press, Elsevier, New York, 2006.

LeVine, III, H. Ch. 12.1 “Reporters of Amyloid Structure”,  in Protein Reviews series, vol. 4 Protein Misfolding, Aggregation, and Conformational Diseases, V. N. Uversky, and A. L. Fink (eds), pp. 287-302, Kluwer Academic / Plenum Publishers, 2006. 

Walker, L. C., LeVine, III, H., and Jucker, M. "Koch's Postulates and Infectious Proteins”, Acta Neuropathologica, 112(1): 1-4 (2006).

Walker, L. C. LeVine, III,  H., Mattson, M. P.,  and Jucker, M. “Inducible Proteopathies”, Trends in Neuroscience 29(8): 438-443 (2006).

LeVine, III, H. and Augelli-Szafran, C.E. “Aβ Polymerization Reduction” (Review) in Protein Folding Diseases: Enzyme Inhibitors & Other Agents as Prospective Therapies, H. John Smith, Claire Simons and Robert D.E. Sewell (eds), CRC Press. in press.