University Of Kentucky - H. Peter Spielmann

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H. Peter Spielmann
Professor
B.S., University of California, Los Angeles, 1984
Ph.D., University of California, Berkeley, 1991
Post-doctoral Fellow, University of California, Berkeley, 1991-95
NIH Post-doctoral Fellow, 1992-94
hps@pop.uky.edu
859-257-4790

H. Peter Spielmann Professor
Department of Biochemistry, University of Kentucky (7/95-present)
Joint appointment
Graduate Center for Toxicology, University of Kentucky (7/96-present)
Joint appointment
Department of Chemistry, University of Kentucky (9/97-present)
Director
Biological NMR Facility, University of Kentucky (7/95-present)

DNA Structure & Function:

Gotfredsen, C. H., Spielmann, H. P., Wengel, J., and Jacobsen, J. P. (1996) "The Structure of a DNA Duplex Containing a Single 2'-O-Methyl-ß-Arabino-Thymidine by Full Relaxation Matrix Refinement" Bioconjugate Chem. 7 680-688. Abstract

Fagan, P. A., Spielmann, H. P., Sigurdsson, S. T., Rink, S. M., Hopkins, P. B., and Wemmer, D. E. (1996) "An NMR Study of d(CGCGAATTCGCG)2 Containing an Interstrand Cross-link Derived from a Distamycin-pyrrole Conjugate" Nucl. Acid. Res. 24, 1566-1573. Abstract

Liu, H., Spielmann, H. P., Ulyanov, N. B., Wemmer, D. E., and James, T. L. (1995) "Interproton Distance Bounds from 2D-NOE intensities: Effect of Experimental Noise and Peak Integration Errors" Journal of Biomolecular NMR 6, 390-402. Abstract

Spielmann, H. P., Chi, D. Y., Hunt, N., Klein, M. P., and Hearst, J. E. (1995) "Spin-Labeled Psoralen Probes for the Study of DNA Dynamics" Biochemistry 34, 14801-14814. Abstract

Spielmann, H. P., Dwyer, T. J., Hearst, J. E., and Wemmer, D. E. (1995) "Structure and dynamics of psoralen furanside monoadducted and cross linked DNA oligomers" Biochemistry 34, 12937-12953. Abstract

Stein, P. C., Jacobsen, J. P., and Spielmann, H. P. (1995) "A Practical Multi-Notch Excitation Filter for Solvent Suppression" J. Magn. Res. 109 93-96. Abstract

Spielmann, H. P., Wemmer, D. E., and Jacobsen, J. P. (1995) "The solution structure of a DNA Complex with the Fluorescent Bis-intercalator TOTO Determined by NMR Spectroscopy" Biochemistry 34, 8542-8553. Abstract

Spielmann, H. P., Fagan, P. A., Bregant, T. M., Little, R. D., and Wemmer, D. E. (1995)"The Binding Modes of a Designed Netropsin-Diazene Photoactivated DNA Cleaving Agent to the Minor Groove of DNA" Nucl. Acid. Res. 23, 1576-1583. Abstract

Spielmann, H. P., Dwyer, T. J., Sastry, S. S., Hearst, J. E., Wemmer, D. E. (1995) "DNA Structural Reorganization Upon Conversion of a Psoralen Furanside Monoadduct to an Interstrand Cross-Link: Implications for DNA Repair" Proc. Nat. Acad. Sci. U. S. A. 92 2345-9. Abstract

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