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CELLULAR STRUCTURE AND FUNCTION
Blackboard: http://elearning.uky.edu  

The 13-week block entitled "Cellular Structure and Function" is composed of two complementary courses.  One of these is the 7-credit biochemistry course BCH/MD-819 and is administered by the Department of Biochemistry.  The other is the 4-credit genetics course MI/MD-815 and is administered by the Department of Microbiology and Immunology.  Separate grades will be given for the two courses.  The objective of this block is to provide students with a sufficient knowledge and understanding of human biochemistry, molecular biology, and genetics to equip them to be outstanding physicians. 

While the block period goes from 8 AM to 12 Noon, the full alloted time is rarely used.  Occasionally, some of non-scheduled time during this block period will be used to make up lecture time in order to get caught up.   

While this block has two distinct components, a great deal of effort has been made to integrate the content presented in the two courses and to include other related information, such as some nutritional aspects.  Based on discussions with previous classes, we have chosen to not use problem-based learning sessions in this block.   

How the performance of the students will be evaluated is detailed in the accompanying information sheets.  It is required that students participate in all scheduled activities.   

Special Note Concerning Clinical Correlations

During these two-hour sessions, typically a patient or patient case relevant to the topics being taught in biochemistry and genetics will be presented.  Where there is a patient, the primary physician will present the case and ask questions of the patient.  The sessions will be opened to questions from the students.  Because these sessions are of a professional nature, students are required to dress accordingly.  Although ties and jackets for the men and dresses for the women are not required, caps, blue jeans and other very casual clothing are inappropriate. 

Cellular Structure & Function - Biochemistry
BCH-819/MD-8198 

UInformation Sheet:

It is assumed that students have a working knowledge of the general principles of chemistry.  BCH-819 concentrates on mammalian biochemistry and its relationship to modern medicine. In keeping with the aims of the first year curriculum, the emphasis in the lectures will be on the biochemistry of the normal individual; disease states will be the focus of other activities. 

Textbooks:

Biochemistry, 3rd Edition (Lippencott) – required

Biochemistry & Genetics Pre-Test USMLE Step 1-type Questions - recommended  

Websites:  All lecture handouts and course information can be downloaded at the MD816/819 link on the Blackboard website:   http://elearning.uky.edu

Examinations: 

There will be four exams in BCH-819.  Collectively, each of these four exams is weighted as 25%; all four exams will constitute 100% of the final numerical grade.  Since biochemistry represents a continuum of related information, each examination will cover all of the material presented up to that exam.  The exams begin at 8 am and end at 10:30 am; 2.5 hours are allotted per exam including the time for answering each question and completely filling out the bubble sheet.  Students are expected to be on time for the exams.  The faculty will not discuss exam questions while the exam is in progress.  During the examination, students are not to have electronic devices such as calculators, cell phones, pagers, PDAs on them.  Instead, these devices should be left either in the student’s locker or at the front of the classroom in the off position.

Test questions may cover material in the assigned reading, material in the lectures, or any clinical correlation.  Additionally, test questions may present novel material that needs to be analyzed based on key principles.  For exams, information discussed in class by the instructor supercedes information from all other sources. 

Exams and the computer sheets are to be turned in immediately after finishing the exam.  Several copies of the exam will be given to the laision committee which can be viewed by students for up to 2 days following the exam.  Exams are not permitted to be photocopied, hand-copied, or kept by the students.  Anything other than viewing of the exam during this period is considered a violation of the ethics code.  Regarding exam questions, disagreements made by individual students are to be presented to the laision committee, not the faculty.  Subsequently, the laision committee will collect the rebuttals of the students’ disagreements and compile a list of up to 5 exam questions to be discussed with the instructors.  For each question to be challenged, the laision committee is to put in writing exactly what the nature of the rebuttal is and forward the compilation to the pertinent instructor one day prior to meeting with the instructor.  Only those rebuttals in the 5 question compilation list will be discussed at the meeting with the instructor.  At that meeting, the exam copies are to be handed in to the instructor. 

Grading:

A student's numerical grade will be based on exams.  Each of the four exams will be equally weighted.  No rounding up of the final numerical grade will be considered.  Letter grades will be assigned based on the summed scores of all exams (with one decimal place) according to the following distribution:   

Grade       Minimum score required

A             1.0 standard deviation above the mean

B             0.5 standard deviations below the mean

C             1.5 std. dev. below the mean or a cumulative average of 66.0% on all 4 tests, whichever is less

U             2.5 standard deviations below the mean

E             Any score more than 2.5 standard deviations below the mean 

Standard deviations for the exams and final scores will be calculated using the Microsoft Excel spreadsheet standard deviation formula and determined by the Office of Education.   

A grade of U is not a passing grade and a student who receives such a grade may, at the discretion of the Student Progress and Promotions Committee, be permitted to take a make-up examination.  Satisfactory performance in the make-up examination would convert the U to a U/C.  A student who receives a grade of E is not eligible for a make-up exam. 

Designated tutor for medical students:  Dr. David Watt, dwatt@uky.edu , 343 BBSRB, tel:  36589


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