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BCH
604 Syllabus
BCH 604 STRUCTURAL BIOLOGY
INSTRUCTORS:
Trevor Creamer David Rodgers
MS675 Medical Science Bldg. MS683 Medical Science Bldg.
323-6037 257-5205
Trevor.Creamer@uky.edu rodgers@focus.gws.uky.edu
Anne-Frances Miller H. Peter Spielmann
113 Chemistry-Physics Bldg. 124A Combs Bldg.
257-9349 257-4790
afm@uky.edu hps@uky.edu
Marcos Oliveira Isaac Wong
516 College of Pharmacy Bldg. 124C Combs Bldg.
323-2710 323-1216
moliv2@uky.edu iwong3@uky.edu
TIME: Monday, Wednesday 10:00-11:15
PLACE: MS605 Medical Science Bldg.
COURSE OBJECTIVES:
Students who complete the course should have a fundamental
understanding of macromolecular structure, the forces that
determine it, and how it relates to function. In particular,
knowledge of the following areas is expected:
-- a familiarity with the NMR, X-ray, and computational
techniques used to study macromolecular structure
-- motions in macromolecules and the functional importance of
dynamics
-- the basis for various types of macromolecular interactions
including protein- protein and protein-nucleic acid
interactions
-- evolutionary relationships of structural features
-- the determinants of protein structure and an understanding
of the current views of protein folding
-- the chemical basis for interactions with enzyme inhibitors
and other ligands
In addition, students will gain experience interpreting and
critically evaluating current reports from the scientific
literature.
COURSE STRUCTURE:
This course will be composed of lectures and discussion
sessions. There will be nine modules that each consist of two
lectures and one student led discussion of papers from the
literature. Each module will cover a topic from the area of
structural biology. In addition, there will be three lectures
that cover introductory material and special topics.
Grades will be based on problem sets associated with the
modules and on class participation. Each problem set will
represent 10% of the final grade and participation will
account for 10%.
The grading standards are as follows:
A 91-100%
B 81-90
C 71-80
D 61-70
E below 61%
Graduate students cannot receive a grade of “D” and will
therefore receive a failing grade for a grade below 71%.
Problem sets will not be accepted after the due date set by
the instructor. The problem set for the last module will be
due on Wed. 15 December. |
