Center of Biomedical Research Excellence in the Molecular Basis of Human Disease
National Institutes of Health, Center of Biomedical Research Excellence (COBRE)
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| Publications December 2007
Garrison JB, Shaw YJ, Chen CS, Kyprianou N.
Novel quinazoline-based compounds impair prostate
tumorigenesis by targeting tumor vascularity. Cancer Res.
2007 Dec 1;67(23):11344-52.
Hou X, Liu R, Ross S, Smart EJ, Zhu H, Gong W.
Crystallographic Studies of Human MitoNEET. J Biol Chem.
2007 Nov 16;282(46):33242-6.
Lu P, Rha GB, Chi YI Structural basis of
disease-causing mutations in hepatocyte nuclear factor
1beta. Biochemistry. 2007 Oct 30;46(43):12071-80.
Smith SJ, McCann RO A C-Terminal Dimerization Motif Is Required for Focal Adhesion Targeting of Talin1 and the Interaction of the Talin1 I/LWEQ Module with F-Actin. Biochemistry. 2007 Sep 25; 46(38):10886-98 Correll RN, Pang C,
Finlin BS, Dailey AM, Satin J, Andres DA. Plasma Membrane Targeting Is
Essential for Rem-mediated Ca2+ Channel Inhibition. J Biol Chem. 2007 Sep
28;282(39):28431-40. June 2007 Horiguchi A, Zheng R, Goodman OB Jr, Shen R, Guan H, Hersh LB, Nanus DM. Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth. Cancer Gene Ther. 2007 Jun;14(6):583-9. Zhang F,
Strom AL, Fukada K, Lee S, Hayward LJ, Zhu H. Interaction
between familial amyotrophic lateral sclerosis (ALS)-linked
SOD1 mutants and the dynein complex. J Biol Chem. 2007 Jun
1;282(22):16691-9. May 2007 Gardner AE, Martin KL, Dutch RE A conserved region between the heptad repeats of paramyxovirus fusion proteins is critical for proper F protein folding. Biochemistry. 2007 May 1;46(17):5094-105. Andrali SS, Qian Q, Ozcan S. Glucose Mediates the Translocation of NeuroD1 by O-Linked Glycosylation. J Biol Chem. 2007 May 25;282(21):15589-96. Zhao C,
Slevin JT, Whiteheart SW. Cellular functions of NSF: Not just
SNAPs and SNAREs. FEBS Lett. 2007 May 29;581(11):2140-9.
Lein PJ, Guo X, Shi GX, Moholt-Siebert M, Bruun D, Andres DA.
The novel GTPase Rit differentially regulates axonal and
dendritic growth. J Neurosci. 2007 Apr 25;27(17):4725-36. March 2007
Dechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann
HP, Sinensky MS, Goldman RD. Alterations in mitosis and cell
cycle progression caused by a mutant lamin A known to
accelerate human aging. Proc Natl Acad Sci U S A. 2007 Mar
20;104(12):4955-60.
Ren Q, Barber HK, Crawford GL, Karim ZA, Zhao C, Choi W, Wang
CC, Hong W, Whiteheart SW. Endobrevin/VAMP-8 Is the Primary
v-SNARE for the Platelet Release Reaction. Mol Biol Cell. 2007
Jan;18(1):24-33. December 2006
Song ES, Cady C, Fried MG, Hersh
LB. Proteolytic Fragments of Insulysin (IDE) Retain
Substrate Binding but Lose Allosteric Regulation.
Biochemistry. 2006 Dec 19;45(50):15085-15091.
York
B, Lou D, Noonan DJ. Tuberin nuclear
localization can be regulated by phosphorylation of its
carboxyl terminus. Mol Cancer Res. 2006 Nov;4(11):885-97.
Crump SM, Correll RN, Schroder EA,
Lester WC, Finlin BS, Andres DA, Satin J.
L-type calcium channel alpha-subunit and protein kinase
inhibitors modulate Rem-mediated regulation of current. Am J
Physiol Heart Circ Physiol. 2006 Oct;291(4):H1959-71. September 2006
Zhu B, Fukada K, Zhu H,
Kyprianou N. Prohibitin and Cofilin Are Intracellular
Effectors of Transforming Growth Factor {beta} Signaling in
Human Prostate Cancer Cells. Cancer Res. 2006 Sep
1;66(17):8640-7.
Finlin BS, Correll RN, Pang C, Crump SM, Satin J, Andres DA.
Analysis of the complex between Ca2+ channel beta-subunit and
the Rem GTPase. J Biol Chem. 2006 Aug 18;281(33):23557-66. June 2006 Lu P, Li Y, Gorman A, Chi YI. Crystallization of hepatocyte nuclear factor 1beta in complex with DNA. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):525-9.
May 2006 April 2006
Mackenzie IR, Baker M, West G,
Woulfe J, Qadi N, Gass J, Cannon A, Adamson J, Feldman H,
Lindholm C, Melquist S, Pettman R, Sadovnick AD, Dwosh E,
Whiteheart SW, Hutton M, Pickering-Brown SM. A family with tau-negative
frontotemporal dementia and neuronal intranuclear inclusions
linked to chromosome 17. Brain. 2006 Apr;129(Pt 4):853-67.
Zhang F, Zhu H (2006)
Intracellular conformational alterations of mutant SOD1 and
the implications for fALS-associated SOD1 mutant induced motor
neuron cell death. Biochim. Biophys. Acta 1760, 404-14. Febuary 2006
Reynolds AR, Kyprianou N. Growth
factor signalling in prostatic growth: significance in tumour
development and therapeutic targeting. Br J Pharmacol. 2006
Feb;147 Suppl 2:S144-52. January 2006
Yikilmaz E, Rodgers DW, Miller
AF. The Crucial Importance of Chemistry in the
Structure-Function Link: Manipulating Hydrogen Bonding in
Iron-Containing Superoxide Dismutase. Biochemistry. 2006 Jan
31;45(4):1151-1161.
Lu X and Zhu H. Tube-Gel
Digestion: A Novel Proteomic Approach for High Throughput
Analysis of Membrane Proteins. Mol Cell Proteomics 2005; 4:
1948-1958.
Rennebeck G, Martelli M,
Kyprianou N. Anoikis and survival connections in the tumor
microenvironment: is there a role in prostate cancer
metastasis? Cancer Res. 2005 Dec 15;65(24):11230-5. November 2005
Shinall H, Song ES, Hersh LB.
Susceptibility of amyloid Beta Peptide degrading enzymes to
oxidative damage: a potential Alzheimer's disease spiral.
Biochemistry. 2005 Nov 22;44(46):15345-50.
Liu K, Zhang X, Sumanasekera C,
Lester RL, Dickson RC. Signalling functions for sphingolipid
long-chain bases in Saccharomyces cerevisiae. Biochem Soc
Trans. 2005 Nov;33(Pt 5):1170-3.
Shi GX, Han J, Andres DA. Rin
GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK
pathways to promote neuronal differentiation. J Biol Chem.
2005 Nov 11;280(45):37599-609. October 2005
Liu K, Zhang X, Sumanasekera C,
Lester RL, Dickson RC. Signalling functions for sphingolipid
long-chain bases in Saccharomyces cerevisiae. Biochem Soc
Trans. 2005 Oct;33(Pt 5):1170-3.
Troutman JM, Roberts MJ, Andres DA,
Spielmann HP. Tools to analyze protein farnesylation in cells. Bioconjug
Chem. 2005 Sep-Oct;16(5):1209-17. August 2005
Tahmatzopoulos A, Sheng S, Kyprianou N.
Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis.
Oncogene. 2005 Aug 11;24(34):5375-83.
July 2005 June 2005
Liu K, Zhang X, Lester RL, Dickson RC. The
sphingoid long chain base phytosphingosine activates AGC-type protein
kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. J Biol
Chem. 2005 Jun 17;280(24):22679-87. May 2005
Subramanian T, Wang Z, Troutman JM, Andres DA, Spielmann HP. Directed
library of anilinogeranyl analogues of farnesyl diphosphate via mixed
solid- and solution-phase synthesis. Org Lett. 2005 May 26;7(11):2109-12.
No Publications for April March 2005 Song ES,
Hersh LB. Insulysin: An Allosteric Enzyme As a Target for Alzheimer's
Disease. J Mol Neurosci. 2005 Mar;25(3):201-206.
Feburary 2005
Ma Z, Wang X,
Hockman S, Snow EC, Hersh LB. Subcellular localization of
nardilysin during mouse oocyte maturation. Arch Biochem
Biophys. 2005 Feb 1;434(1):187-94.
Nath A, Hersh LB. Tat and
amyloid: Multiple interactions. AIDS. 2005 Jan 28;19(2):203-4.
December 2004
Hepp R, Puri N, Hohenstein
AC, Crawford GL, Whiteheart SW, Roche PA. Phosphorylation of
SNAP-23 regulates exocytosis from mast cells. J Biol Chem.
2004 Dec 17; [Epub ahead of print].
Gage RM, Matveeva EA, Whiteheart SW, von Zastrow M.
Type I PDZ ligands are sufficient to promote rapid recycling
of G protein-coupled receptors independent of binding to NSF.
J Biol Chem. 2004 Nov 17; [Epub ahead of print] October 2004
Song ES, Juliano MA, Juliano L, Fried MG,
Wagner SL, Hersh LB. ATP affects on insulin degrading enzyme
are mediated primarily through its triphosphate moiety. J Biol
Chem. 2004 Oct 19 [Epub ahead of print] September 2004 Hill B, Kyprianou N. Effect of permixon on human
prostate cell growth: lack of apoptotic action. Prostate. 2004 Sep
15;61(1):73-80. August 2004 Marinova Z, Yakovleva T, Melzig MF, Hallberg M,
Nylander I, Ray K, Rodgers DW, Hauser KF, Ekstrom TJ, Bakalkin G. A
novel soluble protein factor with non-opioid dynorphin A-binding
activity. Biochem Biophys Res Commun. 2004 Aug 13;321(1):202-9. Shaw YJ, Yang YT, Garrison JB, Kyprianou N,
Chen CS. Pharmacological exploitation of the alpha1-adrenoreceptor
antagonist doxazosin to develop a novel class of antitumor agents
that block intracellular protein kinase B/Akt activation. J Med
Chem. 2004 Aug 26;47(18):4453-62. Huang J, Guan H, Booze RM, Eckman CB, Hersh LB.
Estrogen regulates neprilysin activity in rat brain. Neurosci Lett.
2004 Aug 26;367(1):85-7. Combined April and May 2004 Tahmatzopoulos A, Rowland RG, Kyprianou N. The
role of alpha-blockers in the management of prostate cancer. Expert
Opin Pharmacother. 2004 Jun;5(6):1279-85. Cai Y, Cronin CN, Engel AG, Ohno K, Hersh LB, Rodgers DW. Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders. EMBO J. 2004 May 19;23(10):2047-58. Epub 2004 May 06. Ogura T, Whiteheart SW, Wilkinson AJ. Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases. J Struct Biol. 2004 Apr-May;146(1-2):106-12. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15095758 Whiteheart SW, Matveeva EA. Multiple binding
proteins suggest diverse functions for the N-ethylmaleimide
sensitive factor. J Struct Biol. 2004 Apr-May;146(1-2):32-43. Zhang X, Lester RL, Dickson RC. Pil1p and
Lsp1p negatively regulate the 3-phosphoinositide-dependent protein
kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p
and Ypk1p. J Biol Chem. 2004 May 21;279(21):22030-8. Epub 2004
Mar 11. Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW. Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization. J Biol Chem. 2004 May 7;279(19):20480-9. Epub 2004 Mar 03. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14998993 Duda K, Chi YI, Shoelson SE. Structural
basis for HNF-4alpha activation by ligand and coactivator
binding. J Biol Chem. 2004 May 28;279(22):23311-6. Epub 2004 Feb
24. March 2004 Kim IJ, Drahushuk KM, Kim WY, Gonsiorek
EA, Lein P, Andres DA, Higgins D. Extracellular
signal-regulated kinases regulate dendritic growth in rat
sympathetic neurons. J Neurosci. 2004 Mar
31;24(13):3304-12. Shimojo M, Hersh LB. Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF). Life Sci. 2004 Mar 19;74(18):2213-25. Review. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15017977 Zeng L, Rowland RG, Lele SM, Kyprianou N. Apoptosis incidence and protein expression of p53, TGF-beta receptor II, p27Kip1, and Smad4 in benign, premalignant, and malignant human prostate. Hum Pathol. 2004 Mar;35(3):290-7. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15017584 Zhang X, Lester RL, Dickson RC. Pil1p and
Lsp1p negatively regulate the PDK1-like kinase Pkh1p and
downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem. 2004
Mar 11 [Epub ahead of print]. Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW. Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation and localization. J Biol Chem. 2004 Mar 3 [Epub ahead of print].http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14998993 February 2004 Duda K, Chi YI, Shoelson SE. Structural basis
for HNF-4alpha activation by ligand and coactivator binding. J
Biol Chem. 2004 Feb 24 [Epub ahead of print] Garrison JB, Kyprianou N. Novel targeting of
apoptosis pathways for prostate cancer therapy. Curr Cancer Drug
Targets. 2004 Feb;4(1):85-95. Dean WL, Whiteheart SW. Plasma membrane
Ca(2+)-ATPase (PMCA) translocates to filopodia during platelet
activation. Thromb Haemost. 2004 Feb;91(2):325-33. Ma Z, Chow KM, Yao J, Hersh LB. Nuclear
shuttling of the peptidase nardilysin. Biochem Biophys. 2004 Feb
15;422(2):153-60. Marr RA, Guan H, Rockenstein E, Kindy M, Gage
FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates
amyloid Beta Peptide levels. J Mol Neurosci.
2004 Feb-Apr;22(1-2):5-12. January 2004 Kim MH, Hersh LB. The vesicular acetylcholine
transporter interacts with clathrin-associated adaptor complexes
AP-1 and AP-2. J Biol Chem. 2004 Jan 14 [Epub ahead of print]
Xing H, Mayhew CN, Cullen KE, Park-Sarge OK,
Sarge KD. HSF1 modulation of hsp70 mRNA polyadenylation via
interaction with symplekin. J Biol Chem. 2004 Jan 5 [Epub ahead of
print] December 2003 Shimojo M, Hersh LB. REST/NRSF-interacting
LIM domain protein, a putative nuclear translocation receptor. Mol
Cell Biol. 2003 Dec;23(24):9025-31. Song ES, Juliano MA, Juliano L, Hersh LB.
Substrate activation of insulin-degrading enzyme (insulysin). A
potential target for drug development. J Biol Chem. 2003 Dec
12;278(50):49789-94. Epub 2003 Oct 02. November 2003 Finlin BS, Crump SM, Satin J, Andres DA.
Regulation of voltage-gated calcium channel activity by the Rem
and Rad GTPases. Proc Natl Acad Sci USA 2003 Nov
25;100(24):14469-14474. Epub 2003 Nov 17. Bandhakavi S, McCann RO, Hanna DE, Glover CV.
Genetic interactions among ZDS1,2, CDC37, and protein kinase CK2
in Saccharomyces cerevisiae. FEBS Lett. 2003 Nov
20;554(3):295-300. Puri N, Kruhlak MJ, Whiteheart SW, Roche PA.
Mast cell degranulation requires N-ethylmaleimide-sensitive
factor-mediated SNARE disassembly. J Immunol. 2003 Nov
15;171(10):5345-52. Wu J, Zhu BB, Yu J, Zhu H, Qiu L, Kindy MS, Gu L, Seidel A, Li GM. In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system. Nucleic Acids Res. 2003 Nov 15;31(22):6428-34. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14602900&dopt=Abstract October 2003 Song ES, Juliano MA, Juliano L, Hersh LB.
Substrate activation of insulin degrading enzyme (Insulysin): A
potential target for drug development. J Biol Chem. 2003 Oct 2 [Epub
ahead of print] |
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