Center of Biomedical Research Excellence in the Molecular Basis of Human Disease
National Institutes of Health, Center of Biomedical Research Excellence (COBRE)
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| Current Research Investigators, 2009 – 2010
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Dr. Craig Vander Kooi
Our ultimate goal is to define the fundamental mechanism(s) of neuropilin activity in activation of downstream signaling cascades.
Dr. Matthew Gentry
The long-term objective of this project is to define the relationship between the phosphatase laforin and
AMP-activated protein kinase (AMPK) in two human diseases.
Dr. Christian Paumi
In the current study we will determine the role of CKII in regulating the cellular function of the
MRPs. Ultimately our goal is to define the role of CKII in the regulation of the human
MRPs, MRPI and MRP6. The results of this study will provide valuable insights into how MRP function
is regulated in vivo and will reveal new therapeutic targets for the treatment
Dr. Francesc Marti
The main goal of the project is to uncover the molecular mechanisms by which PUFAs regulate
the T cell response and, specifically, the generation of suppressor ITreg.
Dr. Qingjun Wang
The long-term goal of this project is to understand the molecular mechanism of autophagy in mammals and its
relevance to human diseases, utilizing integrated approaches including mouse genetics, mass spectrometry-based
proteomics and cell biology.
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Current Pilot Investigators, 2009 – 2010
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Dr. Jason Johnston
The specific aim of this project is to identify genes that are regulated by the QshABC system in
NTHi and characterize the regulation. |
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