| Cores |
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Administrative Core
The Administrative Core, comprised of the PI and the senior faculty mentors, oversees the COBRE in
consultation with the Internal and External Advisory Committees. This core facilitates and coordinates
the research and training activities of the COBRE faculty; provides the organizational and administrative
structure needed to insure success of the COBRE in meeting its objectives; provides the leadership and
coordination of the overall research efforts and provides support for grants accounting, preparation of
progress reports and grant writing; and oversees the use of the research core facilities and provide funds
to enhance and utilize the services of these cores. This core also oversees the pilot grant program and
manages the COBRE website.
Protein Analytical Core
The Protein Analytical Core is designed to facilitate protein characterization by COBRE investigators. It will
make available well-maintained equipment and instrumentation that would not normally be found within
individual laboratories, particularly those of junior investigators. In particular, the core will provide equipment
for the production and purification of proteins and their characterization by a number of analytical techniques.
Imaging Core
The overall goal of the core is to serve as a bridge to higher end imaging
methodologies (i.e. confocal). The core allows investigators a rapid and facile way to evaluate their
experiments and to determine if further more extensive analysis is warranted or required.
Proteomics Core
The Proteomics Core is designed to provide quantitative and qualitative protein analysis as well as posttranslational
modification characterization using a combination of gel electrophoresis, liquid chromatography
and mass spectroemtry techniques.
Organic Synthesis Core
The Organic Synthesis Core provides "small molecule" probes to investigators as components of their
proposed projects. Specifically, the Core furnishes modified drugs and natural products tailored to include
suitable functional groups for linkage to proteins, peptide-nucleic-acid (PNA) mimics, and polymers.
Viral Production Core
The Viral Production Core will produce the most frequently used viral vectors for use by COBRE supported
research projects. This includes production of lentivirus, adenovirus, and adeno-associated virus vectors
within the core. |
