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Behavioral Science

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Photo of Dr. AllisonAllison Caban-Holt, Ph.D.

(University of Tennessee, Knoxville (2004), Concentration: Clinical Psychology)

Allison Caban-Holt, Ph.D., Assistant Professor
University of Kentucky, Lexington
303B Sanders-Brown Building
Lexington, KY   40536-0230
Phone: (859) 257-1412 ext. 322
Fax: (859) 323-1772
Email: amcaba2@email.uky.edu

Research Description:

Dr. Caban-Holt’s research focuses on cognition, the behavioral effects of dementia, and detecting dementia through neuropsychological evaluation. Her research experience is quite varied; working on projects such as looking at sleep and agitation in dementia patients, investigating the potential protective effects of Vitamin E and selenium for the prevention of Alzheimer’s disease, and elucidating the challenges for African-American caregivers of dementia patients. Dr. Caban-Holt will be UK site investigator for an Alzheimer’s Disease Cooperative Study-sponsored clinical trial looking at home-based, self-administered assessment methods for identifying cognitive decline in health individuals over the age of 75.

2012 Accomplishments

Allison Caban-Holt, Ph. D. is a co-investigator on a grant entitled “Aging of Frontal Structure and Function in Down Syndrome and Dementia”. Work on this 5-year grant award has expanded Dr. Caban-Holt’s area of expertise in neuropsychological measurement in dementia to include patients with Down Syndrome. In the past year, the project has continued with steady enrollment and presented a symposium in Louisville, KY entitled “Adults with Down Syndrome: Applying Research Findings to Health Brain Aging”. Dr. Caban-Holt completed collection of pilot data from a grant awarded from the Department of Behavioral Science to study prescription drug misuse in a low-income, elderly community sample. Dr. Caban-Holt will collaborate with Dr. Larry Figgs in the College of Public Health to combine this pilot data with health department data to further examine stress and health in these study participants. Initial data analyses have been conducted. She continues as the Protocol Investigator for a multi-site clinical trial sponsored by the Alzheimer’s Disease Cooperative Study looking at home-based assessment measures for detecting changes in cognition in adults over the age of 75. Her study site has maintained over 80% retention of participants over the course of the first 36 months of the 48-month long investigation. She also continues as a co-investigator of the PREADVISE clinical trial which is currently conducting telephone follow-up of over 4,200 men in the U.S. and Canada to determine whether vitamin E and Selenium alone or in combination will reduce the incidence of Alzheimer’s disease. She presented findings from the investigation at the Society for clinical Trials annual meeting in Miami, FL (May, 2012). Dr. Caban-Holt was first-author of a manuscript based on PREADViSE normative data on the Ruff 2&7 Test in older males, and co-authored 3 additional manuscripts in 2012.

Research Funding:

Principal Investigator, Multi-center Trial to Evaluate Home-based Assessment Methods for Alzheimer’s Disease Prevention Research in People Over 75 Years Old, ADCS, 2007-2011.

Co-investigator, Unmet Needs of African-American Dementia Caregivers, Alzheimer’s Association, (2006-2007)

Postdoctoral Scholar, Prevention of Alzheimer’s disease by Vitamin E and Selenium, NIH/NIA, 5 R01 AG019241 (2001-2007)

Publications:

Bottiggi, K., Salazar, J., Yu, L., Caban-Holt, A., Ryan, M., & Schmitt, F. (2007). Concomitant use of medications with anticholinergic properties and acetylcholinesterase inhibitors: Impact on cognitive and physical functioning in Alzheimer’s disease. American Journal of Geriatric Psychiatry, 15(4), 357-9.

Bottiggi, K., Salazar, J., Yu, L., Caban-Holt, A., Ryan, M., Mendiondo, M. & Schmitt, F. (2006). Long-term cognitive impact of anticholinergic medications in older adults. American Journal of Geriatric Psychiatry, 14 (11), 980-4.

Caban-Holt, A., Mendiondo, M., Runyons, C., Kryscio, R., Markesbery, W., & Schmitt, F. (2006). Cognitive screening in the antioxidant AD prevention (PREADVISE) trial: Concordance of MIS and CERAD. Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders (ICAD). Madrid, Spain.

Caban-Holt, A., Schmitt, F.A., Runyons, C.R., Kryscio, R.J., Mendiondo, M.S., Sundquist, M.S., Markesbery, W.R., Coltman, C.A., Crowley, J.J., Goodman, P., & Hartline, J.A. (2006). Studying the effects of vitamin E and Selenium for Alzheimer’s disease prevention: the PREADVISE model. Research and Practice in Alzheimer’s Disease, 11, 124-130.

Caban-Holt, A., Bottiggi, K., & Schmitt, F.A. (2005). Measuring treatment response in Alzheimer’s disease clinical trials. Geriatrics, June 2005 Supplement, 60, 3-8.

Caban-Holt, A., Mattingly, M., Cooper, G., & Schmitt, F.A. (2005). Neurodegenerative memory disorders: A potential role of environmental toxins. Neurologic Clinics, 23, 485-521.

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