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Dr. Supinski's laboratory focuses on two areas of research: (a) respiratory muscle dysfunction in critically
ill patients, and (b) the mechanisms of organ failure and death from sepsis. Both topics are related to critical
care medicine. The goal of their study of respiratory muscle dysfunction is to discover new treatments designed to
improve weaning patients from mechanical ventilation, thereby reducing patient morbidity. The goal of their study
of sepsis is to discover new treatments to prevent multiorgan failure, the leading cause of death in intensive
care units in the United States. They use animal models of disease to establish disease mechanisms and to trial new
therapies and they also study human patients in the ICU to allow them to translate basic science discoveries into
clinical therapies. Dr. Supinski's laboratory uses a mixture of techniques to accomplish these objectives, including
proteomic assessments, physiological assessment of organ and cell function, biochemical assessment of enzyme
pathways, cell culturing techniques, fluorescent microscopy, molecular techniques to alter gene expression,
assessment of organ function in critically ill patients (muscle cardiac, vascular, lung), and muscle biopsy
techniques in patients. |
