Research Interests

Dr. Kern is engaged in both basic and clinical research related to obesity, metabolic syndrome, and diabetes. In clinical studies, Dr. Kern and his colleagues examine adipose tissue and muscle gene expression in relation to insulin resistance. Current themes involve a detailed evaluation of the role of tissue lipotoxicity and inflammation as important factors in obesity related insulin resistance. Current studies are examining the role of omega-3 fatty acids in metabolic syndrome as possible anti-inflammatory agents and as modulators of PPARg. Other studies are examining muscle and adipose tissue inflammation and fibrosis in response to exercise. The potential mechanisms of inflammation-mediated insulin resistance, and possible therapeutic interventions, are being studied both in vitro and in vivo.

Other research involves the gene expression of lipoprotein lipase (LPL), which is an important enzyme in adipose tissue that is involved in triglyceride metabolism, diabetes, and obesity. In recent studies, Dr. Kern’s lab identified components of an RNA binding complex that inhibited LPL translation in response to catecholamines. These data suggest a duel role for cAMP stimulation, resulting in a coordinated response to rapidly promote release of adipocyte lipid and inhibition of lipogenesis, all through posttranscriptional mechanisms.