Zhenheng Guo, Ph.D.
Associate Professor,
Division of Endocrinology
Contact Information |
Training and Publications |
| University of Kentucky |
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| Room 569 Charles T. Wethington Building |
Publication Listing on PubMed |
| 900 South Limestone |
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| Lexington, KY 40536-0200 |
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| Telephone: 859-323-4933 ext. 81416 |
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| Fax: 859-257-3646 |
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Email |
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Research Interests |
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With a long-term goal of identifying novel therapeutic targets for treatment of cardiovascular diseases,
Dr. Guo’s research has focused on the role of vascular smooth muscle cells (VSMC) in cardiovascular diseases. In
particular, Dr. Guo is interested in a specific protein or enzyme, calcium independent phospholipase A2β (iPLA2β)
that expresses in VSMC and is implicated in the pathogenesis of hypertension, restenosis, aortic aneurysm, and
diabetes vascular complications.
The current research projects in Dr. Guo’s laboratory follow:
- The role of VSMC iPLA2β in transcriptional regulation of regulator of G protein signaling 2 (RGS2) by angiotensin II (Ang II) in cultured VSMC
- The role of VSMC iPLA2β in diabetes-associated vascular smooth muscle hypercontractility and hypertension
- The role of VSMC iPLA2β in initiation and early progression of vascular inflammation and neointima formation
- The role of VSMC mineralocorticoid receptor (MR) in deoxycorticosterone acetate (DOCA)- or aldosterone-salt-induced aortic aneurysms
- The role of VSMC BMAL1 in regulation of vascular smooth muscle contractile variability and blood pressure circadian rhythm
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© 2012, University of Kentucky College of Medicine, 138 Leader Ave., Lexington, Kentucky, USA 40506-9983
Student Affairs: (859) 323-5261 · Admissions: (859) 323-6161 · Clinical Questions: (859) 257-1000 · Dean's Office: (859) 323-6582
Page last updated Monday, September 09, 2013
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