2008
- Kleinman ME, Yamada K, Takeda A,Chandrasekaran V, Nozaki M, Baffi J, Albuquerque
RJC, Yamasaki S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Kariko K, Shibuya
M, Ambati BK, Wilgus TA, DiPietro LA, Sakurai E, Zhang K, Smith JR, Taylor
EW, Ambati J. Nature. 2008; 452, 591-597.
- Kleinman ME and Ambati J. 50 years later: the disk goes to the PROM. J.
Clin Invest. 2008. In press.
- Raisler BJ, Nozaki M, Baffi J, Hauswirth WW, Ambati J. 2008. Toward
a higher fidelity model of AMD. Adv. Exp. Med. Biol. 2008;
613: 185-92.
2007
- Chandrasekaran V, Ambati J, Ambati BK, Taylor EW. Molecular docking
and analysis of interactions between vascular endothelial growth factor (VEGF)
and SPARC protein. J
Mol Graph Model. 2007; 26(4): 775-82.
- Singh N, Higgins E, Amin S, Jani P, Richter E, Patel A, Kaur R, Wang J, Ambati
J, Dong Z, Ambati BK. Unique homologous siRNA blocks hypoxia-induced
VEGF upregulation in human corneal cells and inhibits and regresses murine
corneal neovascularization. Cornea. 2007;
26(1): 65-72.
2006
- Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ,
Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y,
Orecchia A, Samuelson DA, Agnew DW, St Leger J, Green WR, Mahasreshti PJ, Curiel
DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana
TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J, Baffi
JZ, Raisler BJ, Ambati J. Corneal avascularity is due to soluble VEGF
receptor-1. Nature. 2006; 443(7114):993-7.
- El-Hage N, Wu G, Ambati J, Bruce-Keller AJ, Knapp PE, Hauser KF. CCR2
mediates increases in glial activation caused by exposure to HIV-1 Tat and
opiates. J
Neuroimmunol. 2006; 178(1-2): 9-16.
- Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA,
Sage EH, Ambati BK, Ambati J. Loss of SPARC-mediated VEGFR-1 suppression
after injury reveals a novel antiangiogenic activity of VEGF-A. J. Clin
Invest. 2006; 116: 422-429.
- Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y,
Zhang K, Ambati BK, Baffi JZ, Ambati J. Drusen complement components
C3a and C5a promote choroidal neovascularization. Proc
Natl Acad Sci . 2006; 14;103(7): 2328-33.
- Ambati BK, Higgins E, Gupta N, Hu G, Kim T, Carlson AN, Ambati J. Eyelid
disease. Ophthalmology.
2005; 112(11):2052-3.
- El-Hage N, Wu G, Wang J, Ambati J, Knapp PE, Reed JL, Bruce-Keller AJ, Hauser
KF. HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis
of microglia through the expression of MCP-1 and alternative chemokines. Glia. 2006;
53: 132-146.
2005
- Singh N, Macnamara E, Rashid S, Ambati J, Kontos CD, Higgins E, Ambati BK. Systemic
soluble Tie2 expression inhibits and regresses corneal neovascularization. Biochem
Biophys Res Commun. 2005;332(1):194-9.
- Singh N, Amin S, Richter E, Rashid S, Scoglietti V, Jani PD, Wang J, Kaur
R, Ambati J, Dong Z, Ambati BK. Flt-1 intraceptors inhibit hypoxia-induced
VEGF expression in vitro and corneal neovascularization in vivo. Invest
Ophthalmol Vis Sci. 2005; 46(5): 1647-52.
2004
- Macnamara E, Sams GW, Smith K, Ambati J, Singh N, Ambati BK. Aquaporin-1
expression is decreased in human and mouse corneal endothelial dysfunction. Mol
Vis. 2004; 10:51-6.
2003
- Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, Rollins BJ,
Ambati BK. An animal model of age-related macular degeneration in senescent
Ccl-2- or Ccr-2-deficient mice. Nat
Med. 2003; 9(11): 1390-7.
- Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y,
Ambati J, Miller JW, Gragoudas ES, Ng YS, D'Amore PA, Shima DT, Adamis AP. VEGF164-mediated
inflammation is required for pathological, but not physiological, ischemia-induced
retinal neovascularization. J
Exp Med. 2003; 198(3): 483-9.
- Sakurai E, Anand A, Ambati BK, van Rooijen N, Ambati J. Macrophage
depletion inhibits experimental choroidal neovascularization. Invest
Ophthalmol Vis Sci. 2003;44(8): 3578-85.
- Ambati BK, Joussen AM, Kuziel WA, Adamis AP, Ambati J. Inhibition of
corneal neovascularization by genetic ablation of CCR2. Cornea. 2003; 22(5): 465-7.
- Sakurai E, Taguchi H, Anand A, Ambati BK, Gragoudas ES, Miller JW, Adamis
AP, Ambati J. Targeted disruption of the CD18 or ICAM-1 gene inhibits
choroidal neovascularization. Invest
Ophthalmol Vis Sci. 2003;44(6): 2743-9.
- Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. Age-related macular
degeneration: etiology, pathogenesis, and therapeutic strategies. Surv
Ophthalmol. 2003; 48(3): 257-93.
- Ambati BK, Anand A, Joussen AM, Kuziel WA, Adamis AP, Ambati J. Sustained
inhibition of corneal neovascularization by genetic ablation of CCR5. Invest
Ophthalmol Vis Sci. 2003; 44(2): 590-3.