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• Sami Dridi, Yoshio Hirano, Valeria Tarallo, Younghee Kim, Benjamin J. Fowler, Balamurali K. Ambati, Sasha Bogdanovich, Vince A. Chiodo, William W. Hauswirth, Jennifer F. Kugel, James A. Goodrich, Steven L. Ponicsan, David R. Hinton, Mark E. Kleinman, Judit Z. Baffi, Bradley D. Gelfand, and Jayakrishna Ambati. ERK1/2 activation is a therapeutic target in age-related macular degeneration. PNAS. August 21, 2012; vol. 109: no. 34, 13781-13786.
• Jayakrishna Ambati, Benjamin J. Fowler. Mechanisms of Age-Related Macular Degeneration. Neuron. Volume 75, Issue 1, 26-39, 12 July 2012.
• Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand, Sami Dridi, Nagaraj Kerur, Younghee Kim, Won Gil Cho, Hiroki Kaneko, Benjamin J. Fowler, Sasha Bogdanovich, Romulo J.C. Albuquerque, William W. Hauswirth, Vince A. Chiodo, Jennifer F. Kugel, James A. Goodrich, Steven L. Ponicsan, Gautam Chaudhuri, Michael P. Murphy, Joshua L. Dunaief, Balamurali K. Ambati, Yuichiro Ogura, Jae Wook Yoo, Dong-ki Lee, Patrick Provost, David R. Hinton, Gabriel Núñez, Judit Z. Baffi, Mark E. Kleinman, and Jayakrishna Ambati. DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88. Cell. 2012; 149: 847-59.

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• Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJC, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J. Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3. Molecular Therapy. (2012); 20 1, 101-108. doi:10.1038/mt.2011.212.
• Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Kariko K, Yoo JW, Lee D-K, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJC, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MMW, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011; 471:325-330.
• Ye Z,Uittenbogaard AM, Cohen DA, Kaplan AM, Ambati J, Straley SC. Distinct CCR2⁺ Gr1⁺ Cells Control Growth of the Yersinia pestis ΔyopM Mutant in Liver and Spleen during Systemic Plague. Infection and Immunity. 2011 Feb; 79(2):674-87.
• Ambati J. Age-Related Macular Degeneration and the Other Double Helix The Cogan Lecture. Invest Ophthalmol Vis Sci. 2011 Apr 5; 52(5):2166-2169.

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• Shibata MA, Ambati J, Shibata E, Albuquerque RJ, Morimoto J, Ito Y, Otsuki Y. The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model. BMC Med. 2010 Nov 3;8:69.
• Pavlakovic H, Becker J, Albuquerque R, Wilting J, Ambati J. Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors. Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1:E7-15.
• Kleinman ME, Baffi JZ, Ambati J. The multifactorial nature of retinal vascular disease. Ophthalmologica. 2010;224 Suppl 1:16-24.
• Kleinman ME, Westhouse SJ, Ambati J, Pearson PA, Halperin LS. Triamcinolone crystal size. Ophthalmology. 2010 Aug;117(8):1654, 1654.e1-4.
• Becker J, Pavlakovic H, Ludewig F, Wilting F, Weich HA, Albuquerque R, Ambati J, Wilting J. Neuroblastoma Progression Correlates with Downregulation of the Lymphangiogenesis Inhibitor sVEGFR-2. Clin Cancer Res. 2010; 16(5), 1431-1441.

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• Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nature Med. 2009; 15, 1023-1030.
• Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJC, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009; 460, 225-230.
• Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J. Small interfering RNA induced TLR3 activation inhibits blood and lymphatic vessel invasion. Proc Natl Acad Sci. 2009; 106(17), 7137-7142.

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• Kleinman ME, Yamada K, Takeda A,Chandrasekaran V, Nozaki M, Baffi J, Albuquerque RJC, Yamasaki S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Kariko K, Ambati BK, Wilgus TA, DiPietro LA, Sakurai E, Zhang K, Smith JR, Taylor EW, Ambati J. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008; 452: 591-597.
• Kleinman ME, Ambati J. Fifty years later: the disk goes to the prom. J Clin Invest. 2008; 118:2681-4.
• Raisler BJ, Nozaki M, Baffi J, Hauswirth WW, Ambati J. Toward a higher fidelity model of AMD.  Adv Exp Med Biol  2008; 613: 185-92.
• Salvatore Ponticelli, Daniela Marasco, Valeria Tarallo, Romulo J. C. Albuquerque, Stefania Mitola, Atsunobu Takeda, Jean-Marie Stassen, Marco Presta, Jayakrishna Ambati, Menotti Ruvo, and Sandro De Falco. Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor 1. J Biol Chem. 2008 Dec 5; 283: 34250-34259.
• Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration. N Engl J Med. 2008; 359:1456-63.

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• Chandrasekaran V, Ambati J, Ambati BK, Taylor EW.  Molecular docking and analysis of interactions between vascular endothelial growth factor (VEGF) and SPARC protein.  J Mol Graph Model.  2007; 26(4): 775-82.
• Singh N, Higgins E, Amin S, Jani P, Richter E, Patel A, Kaur R, Wang J, Ambati J, Dong Z, Ambati BK.  Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization.  Cornea.  2007; 26(1): 65-72.

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• Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ, Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y, Orecchia A, Samuelson DA, Agnew DW, St Leger J, Green WR, Mahasreshti PJ, Curiel DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J, Baffi JZ, Raisler BJ, Ambati J.  Corneal avascularity is due to soluble VEGF receptor-1. Nature.   2006; 443(7114):993-7.
• El-Hage N, Wu G, Ambati J, Bruce-Keller AJ, Knapp PE, Hauser KF.  CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates.  J Neuroimmunol.  2006; 178(1-2): 9-16.
• Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J.  Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.  J Clin Invest.  2006; 116: 422-429.
• Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J.  Drusen complement components C3a and C5a promote choroidal neovascularization.  Proc Natl Acad Sci. 2006; 103(7): 2328-33.
• El-Hage N, Wu G, Wang J, Ambati J, Knapp PE, Reed JL, Bruce-Keller AJ, Hauser KF.  HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines.  Glia.  2006; 53: 132-146.

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• Singh N, Macnamara E, Rashid S, Ambati J, Kontos CD, Higgins E, Ambati BK.  Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization.  Biochem Biophys Res Commun.  2005;332(1):194-9.
• Singh N, Amin S, Richter E, Rashid S, Scoglietti V, Jani PD, Wang J, Kaur R, Ambati J, Dong Z, Ambati BK.  Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo.  Invest Ophthalmol Vis Sci.  2005; 46(5): 1647-52.
• Ambati BK, Higgins E, Gupta N, Hu G, Kim T, Carlson AN, Ambati J.  Eyelid disease. Ophthalmology.   2005; 112(11):2052-3.

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• Macnamara E, Sams GW, Smith K, Ambati J, Singh N, Ambati BK.  Aquaporin-1 expression is decreased in human and mouse corneal endothelial dysfunction.  Mol Vis.  2004; 10:51-6.

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• Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, Rollins BJ, Ambati BK.  An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice.  Nature Med.  2003; 9(11): 1390-7.
• Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J, Miller JW, Gragoudas ES, Ng YS, D'Amore PA, Shima DT, Adamis AP.  VEGF 164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization.  J Exp Med.  2003; 198(3): 483-9.
• Sakurai E, Anand A, Ambati BK, van Rooijen N, Ambati J.  Macrophage depletion inhibits experimental choroidal neovascularization.   Invest Ophthalmol Vis Sci.   2003;44(8): 3578-85.
• Ambati BK, Joussen AM, Kuziel WA, Adamis AP, Ambati J.  Inhibition of corneal neovascularization by genetic ablation of CCR2.  Cornea.  2003; 22(5): 465-7.
• Sakurai E, Taguchi H, Anand A, Ambati BK, Gragoudas ES, Miller JW, Adamis AP, Ambati J.  Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44(6): 2743-9.
• Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP.  Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies.  Surv Ophthalmol. 2003; 48(3): 257-93.
• Ambati BK, Anand A, Joussen AM, Kuziel WA, Adamis AP, Ambati J.  Sustained inhibition of corneal neovascularization by genetic ablation of CCR5.  Invest Ophthalmol Vis Sci.  2003; 44(2): 590-3.

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