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PATTERN ANALYSIS USING EXCEL MACRO.XLS

The Excel macro utilizes our quadratic regression method for pattern analysis in microarray time-course experiment. There are totally 9 possible temporal expression patterns identified by the quadratic regression method, which are illustrated in the figure below.

In the figure, the horizontal axis is time; the vertical axis is the hybridization signals obtained from the microarray; the blue dots are the hybridization signals; the red line or curve is the pattern identified by the quadratic regression method.  FLAT stands for no statistically significant expression over time detected by the regression method; LU stands for linear up regulated regression pattern; LD stands for linear down regulated regression pattern; QC stands for quadratic concave regulated regression pattern: QV stands for quadratic convex regulated regression pattern; QLCU stands for quadratic linear concave up regulated regression pattern: QLCD stands for quadratic linear concave down regulated regression pattern; QLVU stands for quadratic linear convex up regulated regression pattern; QLVD stands for quadratic linear convex down regulated regression pattern.