Michael T. Piascik, Ph.D.
Professor,
The Ohio State University, 1978.
Office: MS-320
Tel: (859) 323-5107
Fax: (859) 323-1981
Currently Dr. Piascik is involved full time in teaching and teaching administration of the various departmental course offerings. Please take a moment to review the material from his various lectures. These include, lecture notes for dental, graduate and medical students. Each series of lectures is prepared specifically for the needs of each professional. This includes lectures on basic pharmacodynamic principles, the theory of drug receptor interactions, autonomic and cardiovascular pharmacology.
Class links:(each opens in a new window)
Reseach Interests
Dr. Piascik’s research interests were in the regulation of cardiovascular function by the alpha1-adrenergic receptor subtypes. These studies were funded by grants from the National Heart, Lung and Blood Institute and the American Heart Association from 1980 through 2007. Alpha1-adrenergic receptors are members of the super family of G-protein coupled receptors. While working with Drs. Robert Graham and Dianne Perez, Dr. Piascik participated in the cloning and characterization of the alpha1A and the alpha1D-AR subtypes. Research techniques used in the lab included whole animal cardiovascular measurements in both rats and genetically altered mice, in vitro assessment of contractile function, measurement of growth responses, measurement of reactive oxygen species, immunocytochemistry and laser scanning confocal microscopy. The overarching hypothesis was that, while all blood vessels express all receptors, a single receptor participates in contractile regulation. Furthermore, this regulatory receptor is different in different vascular beds. We suggested that the alpha1A and the alpha1D-ARs are primarily involved in the regulation of vascular smooth muscle contraction. The major regulatory activity of the alpha1B-AR is in the regulation of hypertrophic growth responses. Dr. Piascik examined the role of the alpha1D-AR in the generation of reactive oxygen species and obtained evidence of a heretofore unrecognized linkage between the alpha1D-AR and the tumor suppressor protein p53. He provided evidence that the alpha1D-AR engages a pathway that ultimately results in p53 executed cell death and present details of the pathway emanating from receptor activation to apoptosis. Below are representative publications that emanated from research in the Piascik laboratory.
Garcia-Cazarin, M.L., Smith, J.L., McCune, D.F., Simmerman, L.A., Hadley, R., Kraner, S.D. and Piascik, M.T. The alpha1D-adrenergic receptor is expressed intracellularly and coupled to increases in intracellular calcium and reactive oxygen species in human aortic smooth muscle cells. Cell Signaling. 3: 6 2008.
Garcia-Cazarin, M.L., Smith, J.L., St. Clair, D. and Piascik, M.T.
The role of the tumor suppressor p53 in alpha1D-adrenergic receptor-induced apoptosis in vascular smooth muscle cells. Mol. Pharmacol. 74: 1000 - 1007, 2008
Cole, M.P., Chaiswing, L., Oberley, T.D., Edelmann, S.E., Piascik, M.T., Lin, S-M, Kiningham, K.K. and St. Clair, D. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovascular Research. 69: 186-197, 2006.
Other Representative Publications
Chalothorn D, McCune DF, Edelmann SE, Tobita K, Keller BB, Lasley RD, Perez DM, Tanoue A, Tsujimoto G, Post GR and Piascik MT. (2003) "Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes." J Pharmacol Exp Ther. 305:1045-53.
Yun J, Zuscik MJ, Gonzalez-Cabrera P, McCune DF, Ross SA, Gaivin R, Piascik MT and Perez DM. (2003) "Gene expression profiling of alpha(1b)-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays." Cardiovasc Res. 57:443-55.
Chalothorn D, McCune DF, Edelmann SE, Garcia-Cazarin ML, Tsujimoto G and Piascik MT. (2002)
Differences in the Cellular Localization and Agonist-Mediated Internalization Properties of the alpha(1)-Adrenoceptor Subtypes. Mol Pharmacol 61:1008-16.
Waldrop, B.A., Piascik, M.T. and Post, G.R. (2002)
Regulation of cell growth and MAPK family members ERK, JNK, and p38 kinase by the Alpha-1B and Alpha-1D adrenergic receptor subtypes. J Pharmacol Expt Ther 300:83-90.
Piascik, M.T. and Perez, D.M. (2001)
Perspectives in a1-adrenergic receptors: Pharmacology, Function and Future Directions., Invited Review, Perspectives in Pharmacology, J Pharmacol Expt Ther 298:403-410.
Zuscik, M.J., Chalothorn, D., Hellard, D., Deighan, C. McGee, A., Daly, C.J., Waugh, D.J.J., Ross, S.A., Gaivin, R.J., Morehead, A.J., Thomas, J.D., Plow, E.F., McGrath, J.C., Piascik, M.T., and Perez, D.M. (2001)
Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice over-expressing the alpha1B-adrenergic receptor. J Biol Chem 276:13738-13743.
McCune DF, Edelmann SE, Olges JR, Post GR, Waldrop BA, Waugh DJJ, Perez DM and Piascik MT. (2000)
Regulation of the Cellular Localization and Signaling Properties of the alphaB- and alpha1D- Adrenoceptors by Agonists and Inverse Agonists. Mol Pharmacol 57: 659-666.
Hrometz SL, Edelmann SE, McCune DF, Olges JR, Hadley RW, Perez DM and Piascik MT. (1999)
Expression of Multiple alpha1-Adrenoceptors on Vascular Smooth Muscle: Correlation with the Regulation of Contraction. J Pharmacol Exp Ther 290: 452-463.
Porter JE, Edelmann S, Waugh DJ, Piascik MT and Perez DM. (1998)
The agonism and synergistic potentiation of weak partial agonists by triethylamine in alpha1 adrenergic receptor activation: Evidence for a salt-bridge as the initiating process. Mol Pharmacol 53:766-771.
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